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Catalase-imprinted Fe3O4/Fe@fibrous SiO2/polydopamine nanoparticles： An integrated nanoplatform of magnetic targeting, magnetic resonance imaging, and dual-mode cancer therapy

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Nano Research 2017年第7期10卷 2351-2363页

作者： Jinxing Chen Shan Lei Kun Zeng Mozhen Wang Anila Asif Xuewu Ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230016 China Interdisciplinary Research Centre in Biomedical Materials (IRCSM) COMSATS Institute of Information Technology Lahore 54000 Pakistan

Recent advances in the research on the molecular mechanism of cell death and methods for preparation of nanomaterials make the integration of various therapeutic approaches, targeting, and imaging modes into a single nanoscale complex a new trend for the development of future nanotherapeutics. Hence, a novel ellipsoidal composite nanoplatform composed of a magnetic Fe3O4/Fe nanorod core （-120 nm） enwrapped by a catalase （CAT）-imprinted fibrous SiO2/ polydopamine （F-SiO2/PDA） shell with thickness 70 nm was prepared in this work. In vitro experiments showed that the Fe3O4/Fe@F-SiO2/PDA nanoparticles can selectively inhibit the bioactivity of CAT in tumor cells by the molecular imprinting technique. As a result, the H2O2 level in tumor cells was elevated dramatically. At the same time, the Fe304FFe core released Fe ions to catalyze the conversion of H2O2 to ＊OH in tumor cells. Eventually, the concentration of ＊OH in tumor cells rapidly rose to a lethal level thus triggering apoptosis. Combined with the remarkable near-infrared light （NIR） photothermal effect of the CAT- imprinted PDA layer, the Fe3O4/Fe@F-SiO2/PDA nanoparticles can effectively kill MCF-7, HeLa, and 293T tumor cells but are not toxic to nontumor cells. Furthermore, these nanoparticles show good capacity for magnetic targeting and suitability for magnetic resonance imaging （MRI）. Therefore, the integrated multifunctional nanoplatform opens up new possibilities for high-efficiency visual targeted nonchemo therapy for cancer.

关键词： molecular imprintednanoparticles reactive oxygen species NIR photothermal therapy magnetic targeting magnetic resonanceimaging (MRI)

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Usefulness of magnetic Particle Imaging for Monitoring the Effect of magnetic targeting

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Open Journal of Medical Imaging 2016年第2期6卷 33-41页

作者： Tomomi Kuboyabu Akiko Ohki Natsuo Banura Kenya Murase Department of Medical Physics and Engineering Division of Medical Technology and Science Faculty of Health Science Graduate School of Medicine Osaka University Osaka Japan

Purpose: magnetic targeting refers to the attachment of therapeutic agents to magnetizable particles such as magnetic nanoparticles (MNPs) and then applying magnetic fields to concentrate them to the targeted region such as solid tumors. The purpose of this study was to investigate the usefulness of magnetic particle imaging (MPI) for monitoring the effect of magnetic targeting using tumor-bearing mice. Materials and Methods: Colon-26 cells (1 × 106 cells) were implanted into the backs of eight-week-old male BALB/c mice. When the tumor volume reached approximately 100 mm3, the mice were divided into treated (n = 8) and untreated groups (n = 8). The tumors in the treated group were directly injected with MNPs (Resovist?, 250 mM) and a neodymium magnet was attached to the tumor surface, whereas the magnet was not attached to the tumor in the untreated group. The mice were imaged using our MPI scanner and the average and maximum MPI values were obtained by drawing a region of interest (ROI) on the tumor, with the threshold value for extracting the contour of the tumor being taken as 40% of the maximum MPI value in the ROI. The relative tumor volume growth (RTVG) was calculated from (V ? V0)/V0, where V0 and V represented the tumor volume immediately before and after the injection of MNPs, respectively. Results: The average and maximum MPI values in the treated group were significantly higher than those in the untreated group 3 days after the injection of MNPs, suggesting the effectiveness of magnetic targeting. There were no significant differences in RTVG between the two groups. Conclusion: Our preliminary results suggest that MPI is useful for monitoring the effect of magnetic targeting.

关键词： magnetic Particle Imaging magnetic targeting magnetic Nanoparticles Tumor-Bearing Mice

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magnetic Biliary Stent targeting to Treat Hepatoma Combining with magnetic Nanoparticles

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Journal of Wuhan University of Technology(Materials Science) 2008年第3期23卷 312-315页

作者：王剑明邹声泉 Department of General Surgery of Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology

To evaluate the effect of targeting to hepatoma treated by magnetic biliary stent combining with magnetic nanoparticle containing 5-fluorouracil （5-FU）, thirty-two nude mice modes with transplanted hepatoma were divided equally into four groups randomly. Experimental group received magnetic biliary stent and magnetic nanoparticles containing 5-FU. The tumor volume and pathomorphology of all groups was measured. The tumor control rate of the experimental group provided magnetic biliary stent wires and magnetic nanoparticles containing 5-FU is remarkably higher than three other control groups, showing significant curative effect. More apoptosis of tumor cells could be detected easily in experimental group. There are more apoptotic bodies and phagotrophic magnetic particle in apoptosis cells of experimental group under electron microscope. magnetic biliary stent combining with magnetic nanoparticle containing 5-FU could inhibit the growth of hepatoma, and its curative effect is more remarkable than the traditional methods based on external magnetic fields.

关键词： magnetic biliary stent magnetic targeting magnetic nanoparticle chemotherapy hepatoma

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Versatile graphitic nanozymes for magneto actuated cascade reaction-enhanced treatment of *** biofilms

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Nano Research 2022年第11期15卷 9800-9808页

作者： Qian Dong Zhaoqian Li Jieqiong Xu Quan Yuan Long Chen Zhuo Chen Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Faculty of Science and Technology University of MacaoTaipaMacao 999078China

Pathogenic oral biofilms especially acid-producing ones cause a variety of oral diseases such as dental *** that bacteria are embedded within the biofilms matrix to prevent the penetration of therapeutic drugs,people have explored the applications of nanoparticles to treat oral ***,current nanoparticle-mediated eradication has not achieved the precise treatment of biofilms,and the stabilities of nanoparticles go on strike because of acidic environment leading to poor therapeutic ***,we design an integrated nanozyme,CoPt@graphene@glucose oxidase(CoPt@G@GOx),which has cascade reaction activity with two-step *** peroxide(H_(2)O_(2))produced through the glucose oxidation by GOx serves as the substrate for peroxidase-mimic CoPt@G to produce highly toxic hydroxyl radical under acidic *** to the simple mixture of GOx and CoPt@G,CoPt@G@GOx shows around fourfold catalytic effect ***,CoPt@G@GOx can precisely target the location of the biofilms,which ensures the minimal impact on normal *** on the advantage of the magneto-actuated cascade catalytic activity,CoPt@G@GOx reveals a superior antibacterial ability in the Streptococcus mutans biofilms ***,our results provide an easy and effective method to exploit bifunctional nanozyme as a novel topical agent to prevent the prevalent biofilm-induced oral disease.

关键词： nanozyme biofilm magnetic targeting platinum antibacterial effect

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Progress in cancer therapy with functionalized Fe_(3)O_(4) nanomaterials

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Frontiers of Materials Science 2023年第3期17卷 57-70页

作者： Yuhui Wang Xuanyu Liu Shilong Ma Xuhong He Chaiqiong Guo Ziwei Liang Yinchun Hu Yan Wei Xiaojie Lian Di Huang Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringShanxi Key Laboratory of Materials Strength&Structural ImpactTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Malignant neoplasms represent a significant global health *** address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic *** oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high *** ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such *** methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting *** systems can be created by combining Fe_(3)O_(4) NPs with *** combining various therapeutic approaches,more effective biomedical materials can be *** paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.

关键词： Fe_(3)O_(4)NPs cancer treatment magnetic targeting magnetic thermotherapy

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Superparamagnetic iron oxide nanoparticle targeting of adipose tissue-derived stem cells in diabetes-associated erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 425-432页

作者： Lei-Lei Zhu Zheng Zhang He-Song Jiang Hai Chen Yun Chen Yu-Tian Dai Department of Andrology Drum Tower Hospital School of Medicine Nanjing University Nanjing 210008 China

Erectile dysfunction （ED） is a major complication of diabetes, and many diabetic men with ED are refractory to common ED therapies. Adipose tissue-derived stem cells （ADSCs） have been shown to improve erectile function in diabetic animal models. However, inadequate cell homing to damaged sites has limited their efficacy. Therefore, we explored the effect of ADSCs labeled with superparamagnetic iron oxide nanoparticles （SPIONs） on improving the erectile function of streptozotocin-induced diabetic rats with an external magnetic field. We found that SPIONs effectively incorporated into ADSCs and did not exert any negative effects on stem cell properties. magnetic targeting of ADSCs contributed to long-term cell retention in the corpus cavernosum and improved the erectile function of diabetic rats compared with ADSC injection alone. In addition, the paracrine effect of ADSCs appeared to play the major role in functional and structural recovery. Accordingly, magnetic field-guided ADSC therapy is an effective approach for diabetes-associated ED therapy.

关键词： erectile dysfunction magnetic targeting stem cells superparamagnetic iron oxide nanoparticles

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Sorafenib delivery nanoplatform based on superpara- magnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

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Nano Research 2017年第7期10卷 2431-2448页

作者： Nicoletta Depalo Rosa Maria lacobazzi Gianpiero Valente Ilaria Arduino Silvia Villa Fabio Canepa Valentino Laquintana Elisabetta Fanizza Marinella Striccoli Annalisa Cutrignelli Angela Lopedota Letizia Porcelli Amalia Azzariti Massimo Franco Maria Lucia Curri Nunzio Denora Istituto per i Processi Chimico-Fisici-CNR UOS Bari Via Orabona 4 70125 Bari Italy Istituto Tumori IRCCS Giovanni Paolo II viale O. Flacco 65 70124 Bari Italy Dipartimento di Chimica Universita degli Studi di Bad Aldo Moro Via Orabona70125 Bari Italy Dipartimento di Farmacia-Scienze del Farmaco Universita degli Studi di Bari Aldo Moro Via Orabona 4 70125 Bari Italy Dipartimento di Chimica e Chimica Industriale Universita di Genova Via Dodecaneso 31 16146 Genova Italy

Currently, sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients. Unfortunately, its side effects, particularly its overall toxicity, limit the therapeutic response that can be achieved. Superparamagnetic iron oxide nanoparticles （SPIONs） are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field, thus improving intratumoral accumulation and reducing adverse effects. Here, nanoformulations based on polyethylene glycol modified phospholipid micelles, loaded with both SPIONs and sorafenib, were successfully prepared and thoroughly investigated by complementary techniques. This nanovector system provided effective drug delivery, had an average hydrodynamic diameter of about 125 nm, had good stability in aqueous medium, and allowed controlled drug loading. magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle. An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver. Human hepatocellular carcinoma （HepG2） cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib. These experiments demonstrated that this delivery platform is able to enhance sorafenib＇s antitumor effectiveness by magnetic targeting. The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites, where selective release of sorafenib can improve its efficacy and safety profile.

关键词： superparamagnetic ironoxide nanoparticles poly(ethylene glycol) (PEG)-modified phospholipidmicelles drug delivery magnetic targeting hepatocellular carcinoma sorafenib

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Ferrimagnetic m PEG-b-PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermia–chemotherapy

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National Science Review 2020年第4期7卷 723-736页

作者： Yonghong Song Dongdong Li Yang Lu Kun Jiang Yi Yang Yunjun Xu Liang Dong Xu Yan Daishun Ling Xianzhu Yang Shu-Hong Yu Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes Hefei University of Technology Institutes for Life Sciences School of Medicine South China University of Technology Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Nanoscience Hefei Science Center of CASDepartment of Chemistry Institute of Biomimetic Materials & Chemistry University of Science and Technology of China Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical Sciences Key Laboratory of Biomedical Engineering of the Ministry of Education Zhejiang University

As a non-invasive therapeutic method without penetration-depth limitation, magnetic hyperthermia therapy(MHT) under alternating magnetic field(AMF) is a clinically promising thermal ***, the poor heating conversion efficiency and lack of stimulus–response obstruct the clinical application of magnetofluid-mediated MHT. Here, we develop a ferrimagnetic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)(m PEG-b-PHEP) copolymer micelle loaded with hydrophobic iron oxide nanocubes and emodin(denoted as EMM). Besides an enhanced magnetic resonance(MR) contrast ability(r2= 271 m M-1s-1) due to the high magnetization, the specific absorption rate(2518 W/g at 35 k A/m) and intrinsic loss power(6.5 n Hm2/kg) of EMM are dozens of times higher than the clinically available iron oxide nanoagents(Feridex and Resovist), indicating the high heating conversion efficiency. Furthermore, this composite micelle with a flowable core exhibits a rapid response to magnetic hyperthermia, leading to an AMF-activated supersensitive drug release. With the high magnetic response, thermal sensitivity and magnetic targeting, this supersensitive ferrimagnetic nanocomposite realizes an above 70% tumor cell killing effect at an extremely low dosage(10 μg Fe/m L),and the tumors on mice are completely eliminated after the combined MHT–chemotherapy.

关键词： magnetic hyperthermia therapy sensitive thermal response chemotherapy magnetic targeting theranostics

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Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

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Journal of Materials Science & Technology 2021年第10期69卷 69-78页

作者： Kecheng Quan Zexin Zhang Yijin Ren Henk J.Busscher Henny C.van der Mei Brandon W.Peterson College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China University of Groningen and University Medical Center Groningen Department of Biomedical Engineering9713 AVGroningenthe Netherlands University of Groningen and University Medical Center Groningen Department of OrthodonticsHanzeplein 19713 GZGroningenthe Netherlands

targeting of chemotherapeutics towards a tumor site by magnetic nanocarriers is considered promising in *** nanoparticles are also considered for use in infection-control as a new means to prevent antimicrobial resistance from becoming the number one cause of death by the year *** this end,magnetic nanoparticles can either be loaded with an antimicrobial for use as a delivery vehicle or modified to acquire intrinsic antimicrobial *** nanoparticles can also be used for the local generation of heat to kill infectious *** appealing for tumor-and infectioncontrol,injection in the blood circulation may yield reticuloendothelial uptake and physical obstruction in organs that yield reduced targeting *** can be prevented with suitable surface ***,precise techniques to direct magnetic nanoparticles towards a target site are *** problem of precise targeting is aggravated in infection-control due to the micrometer-size of infectious biofilms,as opposed to targeting of nanoparticles towards centimeter-sized *** review aims to identify possibilities and impossibilities of magnetic targeting of nanoparticles for *** first review targeting techniques and the spatial resolution they can achieve as well as surface-chemical modifications of magnetic nanoparticles to enhance their targeting efficiency and antimicrobial *** is concluded that targeting problems encountered in tumor-control using magnetic nanoparticles,are neglected in most studies on their potential application in *** biofilm targeting by smart,self-adaptive and pH-responsive,antimicrobial nanocarriers for instance,seems easier to achieve than magnetic *** leads to the conclusion that magnetic targeting of nanoparticles for the control of micrometer-sized infectious biofilms may be less promising than initially ***,using propulsion rather than pr

关键词： magnetic nanoparticles magnetic targeting Biofilm Infection Antimicrobials

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Fabrication of a Magnetite Nanoparticle-loaded Polymeric Nanoplatform for magnetically Guided Drug Delivery

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Chemical Research in Chinese Universities 2013年第1期29卷 103-109页

作者： DING Guo-bin LIU Hui-yin WANG Yan LU Yan-yun WU Yi GUO Yi XU Li Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Life Science Jilin University Changchun 130012 P. R. China" College of Pharmacy Jilin University Changchun 130021 P. R. China School of Stomatology Dalian Medical University Dalian 116044 P. R. China

We developed a magnetite nanoparticle-loaded polymeric nanoplatform for magnetically guided 10- hydroxycamptothecin（HCPT） delivery. The nanoplatform was fabricated by simultaneously incorporating magnetite nanoparticles（NPs） and HCPT into the polymer micelle self-assembled from methoxy polyethylene glycolpoly（D,L-lactide-co-glycolide）（MPEG-PLGA） copolymer. Successful loading of HCPT into the nanoplatform was confirmed by Fourier transform infrared（FTIR） spectroscopy. Subsequently, we examined the in vitro antitumor efficacy of free HCPT and nanoplatform against three different cancer cell lines HeLa, A549 and HepG2. Flow cytometric analysis was condkt ,ucted to reveal the cell apoptosis caused by free HCPT and nanoplatform. Finally, the magnetic targeting property of the nanoplatform was evaluated by a self-designed in vitro experiment.

关键词： Magnetite nanoparticle 10-Hydroxycamptothecin(HCPT) Nanoplatform magnetic targeting

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