Versatile graphitic nanozymes for magneto actuated cascade reaction-enhanced treatment of *** biofilms

作     者：Qian Dong Zhaoqian Li Jieqiong Xu Quan Yuan Long Chen Zhuo Chen Qian Dong;Zhaoqian Li;Jieqiong Xu;Quan Yuan;Long Chen;Zhuo Chen

作者机构：Molecular Science and Biomedicine Laboratory(MBL)State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Faculty of Science and TechnologyUniversity of MacaoTaipaMacao 999078China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第11期

页      面：9800-9808页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1003[医学-口腔医学] 081704[工学-应用化学] 07[理学] 0806[工学-冶金工程] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：financially supported by the National Key Research and Development Program of China(No.2020YFA0210800) the Science and Technology Innovation Program of Hunan Province(No.2020RC4017) the Science and Technology Development Fund,Macao(No.196/2017/A3) 

主　　题：nanozyme biofilm magnetic targeting platinum antibacterial effect 

摘      要：Pathogenic oral biofilms especially acid-producing ones cause a variety of oral diseases such as dental *** that bacteria are embedded within the biofilms matrix to prevent the penetration of therapeutic drugs,people have explored the applications of nanoparticles to treat oral ***,current nanoparticle-mediated eradication has not achieved the precise treatment of biofilms,and the stabilities of nanoparticles go on strike because of acidic environment leading to poor therapeutic ***,we design an integrated nanozyme,CoPt@graphene@glucose oxidase(CoPt@G@GOx),which has cascade reaction activity with two-step *** peroxide(H_(2)O_(2))produced through the glucose oxidation by GOx serves as the substrate for peroxidase-mimic CoPt@G to produce highly toxic hydroxyl radical under acidic *** to the simple mixture of GOx and CoPt@G,CoPt@G@GOx shows around fourfold catalytic effect ***,CoPt@G@GOx can precisely target the location of the biofilms,which ensures the minimal impact on normal *** on the advantage of the magneto-actuated cascade catalytic activity,CoPt@G@GOx reveals a superior antibacterial ability in the Streptococcus mutans biofilms ***,our results provide an easy and effective method to exploit bifunctional nanozyme as a novel topical agent to prevent the prevalent biofilm-induced oral disease.