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Comparison and interchangeability of macular thickness measured with Cirrus OCT and Stratus OCT in myopic eyes

International Journal of Ophthalmology(English edition) 2015年第6期8卷 1196-1201页

作者： Geng Wang Kun-Liang Qiu Xue-Hui Lu Ming-Zhi Zhang Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong

AIMTo investigate the difference of macular thickness measurements between stratus optical coherence tomography (OCT) and Cirrus OCT (Carl Zeiss Meditec, Dublin, CA, USA) in the same myopic patient and to develop a conversion equation to interchange macular thickness obtained with these two OCT ***-nine healthy Chinese adults with spherical equivalent (SE) ranging from -1.13 D to -9.63 D were recruited. The macular thickness was measured by Cirrus OCT and Stratus OCT. The correlation between macular thickness and axial length and the agreement between two OCT measurements were evaluated. A formula was generated to interchange macular thickness obtained with two OCT *** macular thickness measured with Stratus OCT (r=-0.280, P=0.008) and Cirrus OCT (r=-0.224, P=0.034) were found to be negatively correlated with axial length. No statistically significant correlation was found between axial length and central subfield macular thickness (CMT) measured with Stratus OCT (r=0.191, P=0.073) and Cirrus OCT (r=0.169, P=0.113). The mean CMT measured with Cirrus OCT was 53.63±7.94 µm thicker than with Stratus OCT. The formula CMTCirrus OCT=78.328+0.874×CMTStratus OCT was generated to interchange macular thickness obtained with two OCT *** thickness measured with Cirrus OCT were thicker than with Stratus OCT in myopic eyes. A formula can be used to interchange macular thickness measured with two OCT devices in myopic eyes. Studies with different OCT devices and larger samples are warranted to enable the comparison of macular values measured with different OCT devices.

关键词： myopia macular thickness spectral domain Cirrus OCT time domain Stratus OCT interchangeability

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Comparison of retinal nerve fiber layer and macular thickness measurements with Stratus OCT and OPKO/OTI OCT devices in healthy subjects

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 98-103页

作者： Ahmet Ozkok Julide Canan Umurhan Akkan Nevbahar Tamcelik Mehmet Erdogan Didar Ucar Comlekoglu Rengin Yildirim Department of Ophthalmology Cerrahpasa School of MedicineIstanbul University Department of Ophthalmology School of MedicineBezmialem Vakif University

AIM: To compare retinal nerve fiber layer(RNFL) and macular thickness measurements obtained with the Stratus optical coherence tomography(OCT) and OPKO/OTI OCT ***: Included in the study were 59 eyes of 30 participants. All measurements for each eye were done on the same day with both devices. Student’s paired t-tests were used to compare the central macular thickness and RNFL measurements of the Stratus OCT and OPKO/OTI OCT. Pearson correlation was used to assess the relationship between the devices. Coefficient of variation(COV) was calculated to assess intersession ***: Using both the Stratus OCT and OPKO/OTI OCT, respectively, the measured mean average RNFL thicknesses were 98.9±11.1 μm and 115.1±9.6 μm(P =0.001),and the measured mean central retinal thicknesses(CRT)were 196.2 ±18.8 μm and 204.5 ±21.1 μm(P thickness values were correlated in all quadrants, as were the retinal thickness values except the inferior outer sector. COV for average RNFL and CRT thickness were 2.9% and 4.6%for Stratus OCT, and 2.1% and 4.2% for OPKO/OTI OCT,***: We found good reproducibility of RNFL and retina thickness measurements for both Stratus OCT and OPKO/OTI OCT devices. However, even though the two OCT systems provided statistically correlated results,the values for both RNFL and macular thickness were statistically different. RNFL and macular thickness measurements with the OPKO/OTI OCT were higher than that of the Stratus OCT; therefore, the two OCT systems cannot be used interchangeably for the measurements of RNFL and macular thickness.

关键词： optical coherence tomography Stratus optical coherence tomography OPKO/OTI OCT retinal nerve fiber layer macular thickness

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macular thickness by Optical Coherence Tomography in Normal Togolese Melanoderma Subjects: A Case Study of 338 Eyes

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Open Journal of Ophthalmology 2022年第1期12卷 44-50页

作者： Kossi Dzidzinyo Akoete Djagnikpo Koffi Didier Ayena Kokou Vonor Mawouli Ayodele Santos Kassoula Batomaguela Nonon-Saa Kokou Messan Amedome Adam Nouhou-Diori Nidain Maneh Komi Balo Department of Ophthalmology Sylvanus Olympio University Hospital Lomé Togo Sight & Vision Ophthalmology Clinic Lomé Togo Department of Ophthalmology Secondary Hospital of Bè Lomé Togo Department of Ophthalmology Kara University Hospital Kara Togo Department of Ophthalmology Regional Hospital Center of Aneho Aneho Togo Department of Ophthalmology Campus University Hospital University of Lomé Lomé Togo

Objective: Maculopathies are more and more frequent. For the follow-up of its evolution and therapy, it seems important for us to determine the baseline in normal subjects by Optical Coherence Tomography (OCT). The goal here is to determine the acceptable range of macular thickness in normal black subjects in Lomé. Methodology: This is a retrospective study over a 6-month period. It did not include all patients with retinopathy of any cause, maculopathy, and glaucoma. The analyzed variables were the average macular thickness, the central macular thickness, and the total macular volume. Results: Out of the 433 macular OCT performed, 191 patients were selected;a total of 338 eyes. These included 96 men and 95 women. A sex ratio was 1.01. The median age was 44.1 years with extremes ranging from 10 to 70 years. The average macular thickness was 263.4 μm for the right eye and 263.7 μm for the left eye. The central macular thickness was 174.1 μm for the right eye and 173.3 μm for the left eye. The total macular volume was 7.4 in both eyes. Discussion: No significant statistical difference existed between the two sexes. The average macular thickness found in this study was within the range of normality observed in the literature, which is between 216 and 288 μm. Conclusion: The average macular thickness of the normal subject in Lomé was 263.4 μm.

关键词： macular thickness OCT Normal Subject

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Analysis of macular microvasculature and thickness after ICL implantation in patients with myopia using optical coherence tomography

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1948-1954页

作者： Qiu-Jian Zhu Meng-Yu Wang Peng Yu Xiao-Suo Liang Lie Ma Hai-Xiang Xiao You Yuan Department of Ophthalmology Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate changes in macular vessels and thickness in myopic eyes after intraocular collamer lens(ICL)implantation using quantitative optical coherence tomography angiography(OCTA).METHODS:This retrospective included 73 myopic eyes of 73 patients(average age,27.53±6.16 y)who underwent ICL implantation(28 eyes were Toric ICL).Axial length(AL),uncorrected visual acuity(UCVA),refractive dioptre(RD),intraocular pressure(IOP)and OCTA were measured and compared with before and 1 wk,1,and 3 mo after *** was used to image vessel density(VD)and skeleton density(SD)in both the superficial(SCP)and deep capillary plexus(DCP).Central retinal thickness(CRT)and ganglion cellinner plexiform layer thickness(GCT)were also *** between pre-and postoperative measurements were analysed by repeated measures analysis of ***:Compared with preoperative data,postoperative data on UCVA revealed significant improvements in all patients(Pmacular area changes that occur after surgery need attention.

关键词： intraocular collamer lens implantation vessel density macular thickness optical coherence tomography angiography

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macular and peripapillary retinal nerve fiber layer thickness in children with hyperopic anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 85-89页

作者： Shuang-Qing Wu Li-Wei Zhu Qi-Bin Xu Jun-Li Xu Yu Zhang Department of Ophthalmology Hangzhou Red Cross Hospital

AIM:To compare the retinal nerve fiber layer (RNFL) thickness and macular thickness in the amblyopic eye with that in the sound eye of children with hyperopic anisometropic amblyopia using optical coherence tomography (OCT). METHODS:A prospective, nonrandom, intraindividual comparative cohort study includes 72 children with hyperopic anisometropic amblyopia in a single center. macular thickness, macular foveola thickness, and peripapillary RNFL thickness were compared between the amblyopia eyes and the contralateral sound eyes. ·RESULTS:There were 38 male and 34 female patients, with a mean age as 9.7 ±1.9 years (range, 5-16 years). Hyperopic was +3.62±1.16D (range +2.00D to +6.50D) in the amblyopic eyes, which was significantly higher in the control eyes with +0.76±0.90D (range 0D to +2.00D) (P thickness was 113.9± 7.2μm and 109.2 ±6.9μm in the amblyopic eye and the normal eye, respectively, reaching statistical significance (P = 0.02). The mean macular foveola thickness was significantly thicker in the amblyopic eyes than the contralateral sound eyes (181.4±14.2μm vs 175.2±13.3μm, P macular thickness central macular thickness was not significantly different. Degree of anisometropia in the contralateral eyes was not significantly correlated with differences of peripapillary RNFL, macular foveola thickness or central macular thickness. CONCLUSION:Eyes with hyperopic anisometropic amblyopia are found thicker macular foveola and peripapillary RNFL than the contralateral eyes in children.

关键词： hyperopic anisometropic amblyopia retinal nerve fiber thickness macular thickness optical coherence tomography children

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Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease:a meta-analysis

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Neural Regeneration Research 2023年第11期18卷 2504-2513页

作者： Samran Sheriff Ting Shen Sandra Abdal Danit Saks Mehdi Mirzaei Veer Gupta Nitin Chitranshi Yuyi You Angela Schultz Stuart L.Graham Vivek Gupta Macquarie Medical School Macquarie UniversitySydneyNSWAustralia Save Sight Institute The University of SydneySydneyNSWAustralia School of Medicine Deakin UniversityMelbourneVICAustralia

Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the *** this metaanalysis,we aimed to investigate the association of various optical coherence tomography parameters with Alzheimer’s disease and whether retinal measurements can be used to diffe rentiate between Alzheimer’s disease and control *** databases including Google Schola r,Web of Science,and PubMed were systematically searched for published articles that evaluated retinal nerve fiber layer thickness and retinal microvascular network in Alzheimer’s disease and control ***-three studies(5850 participants,including 2249 Alzheimer’s disease patients and 3601controls) were included in this *** to controls,Alzheimer’s disease patients had a significantly lower global retinal nerve fiber layer thickness(standardized mean difference [SMD]=-0.79,95% confidence intervals [CI]:-1.03 to-0.54,P macular paramete rs,values measured by optical coherence tomography were significantly lower in Alzheimer’s disease than controls for macular thickness(pooled SMD:-0.44,95% CI:-0.67 to-0.20,P=0.0003),foveal thickness(pooled SMD=-0.39,95% CI:-0.58 to-0.19,P macular volume(pooled SMD=-0.41,95% CI-0.76 to-0.07,P=0.02).Analysis using optical coherence tomography angiography parameters revealed mixed results between Alzheimer’s disease and *** vessel density(pooled SMD=-0.42,95% CI:-0.68 to-0.17,P=0.0001) and deep vessel density(pooled SMD=-0.46,95% CI:-0.75 to-0.18,P=0.001) were found to be thinner in Alzheimer’s disease patients whereas the foveal avascular zone(SMD=0.84,95% CI:0.17-1.51,P=0.01) was larger in *** density and thickness of variou

关键词： Alzheimer’s disease foveal avascular zone macular thickness optical coherence tomography optical coherence tomography angiography retina retinal nerve fiber layer vessel density

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Intraocular retinal thickness asymmetry in early stage of primary open angle glaucoma and normal tension glaucoma

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1342-1351页

作者： Pei-Wen Lin Hsueh-Wen Chang Ing-Chou Lai Jen-Chia Tsai Yi-Chieh Poon Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Biological Sciences Sun Yat-Sen University

AIM： To investigate the intraocular retinal thickness asymmetry of peripapillary retinal nerve fiber layer（pR NFL） and macular layers measured by spectral-domain optical coherence tomography（SD-OCT） in patients with early stage of primary open angle glaucoma（POAG） and normal tension glaucoma（NTG）.METHODS： A total of 117 patients with early stage of glaucoma（54 patients with POAG and 63 patients with NTG） and 32 normal subjects were recruited for the study. The pR NFL thickness, total macular layer（TML） thickness, and isolated inner macular layer（IML） thickness were measured by SD-OCT. Hemisphere TML thickness asymmetry measured by the posterior pole asymmetry scan was evaluated. thickness differences of pR NFL and IML between superior and inferior quadrants were calculated. Asymmetry indices（AIs） of the p RNFL, TML and isolated IML were also computed. Areas under the receiver-operating characteristic curves（AROCs） were generated to determine the diagnostic capabilities of different parameters. RESULTS： Intraocular p RNFL thickness differences and AIs between the superior and inferior quadrants were significantly different between normal and NTG groups（P=0.009 and P〈0.001, respectively）. Intraocular p RNFL thickness differences and AIs between the temporal-superior and temporal-inferior sectors were also significantly different between normal and NTG groups（P=0.035 and P〈0.001, respectively）. The thickness differences and AIs of TML between superior and inferior hemispheres were significantly different between normal and NTG groups（P=0.001 and P=0.001, respectively） and between normal and POAG groups（P=0.032 and P=0.020, respectively）. The thickness differences and AIs of macular ganglion cell layer（mG CL） between superior and inferior quadrants were significantly different between normal and NTG groups（P=0.013 and P=0.004, respectively）, and between NTG and POAG groups（P=0.015 and P=0.012, respectively）. The thickness difference of TML between superior and inferior

关键词： retinal nerve fiber layer macular thickness primary open angle glaucoma normal tension glaucoma hemisphere retinal asymmetry optical coherence tomography

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Parameters of ocular fundus on spectral-domain optical coherence tomography for glaucoma diagnosis

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 982-991页

作者： Yu-Lin Tao Li-Ming Tao Zheng-Xuan Jiang He-Ting Liu Kun Liang Mo-Han Li Xuan-Sheng Zhu Yan-Lin Ren Bing-Jie Cui Department of Ophthalmology the First People＇s Hospital of Jiujiang City Jiujiang 332000 Jiangxi Province China Department of Ophthalmology the Second Affiliated Hospital of Anhui Medical University Hefei 230000 Anhui Province China 3Department of Ophthalmology the Fuyang Affiliated Hospital of Anhui Medical University Fuyang 236000 Anhui Province China

In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography （SD-OCT） in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer （RNFL） thickness is essential. Imaging and analysis of retinal ganglion cells （RGCs） and inner plexiform layer （IPL）, respectively, have been of great importance. Optic nerve head （ONH） topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch＇s membrane opening （BMO）, estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement. Still other parameters found in the past three years for glaucoma diagnosis comprise central retinal artery resistive index, optic disc perfusion in optical coherence tomography angiography （OCTA） study, peripapillary choroidal thickness, and choroidal area in SD-OCT. Recently, several more ocular fundus parameters have been found, and compared with the earlier parameters to judge the accuracy of diagnosis. While a few of these parameters have been widely used in clinical practice, a fair number are still in the experimental stage.

关键词： glaucoma progression retinal nerve fiberlayer ganglion cells macular thickness optic nerve head lamina cribrosa optical coherence tomography

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Long-term effect of prophylactic laser treatment for bilateral soft drusen

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Chinese Medical Journal 2011年第4期124卷 541-545页

作者： HUANG Ying-xiang XIANG Li-nan WANG Yan-ling LI Ming-min HU Yong-xia Department of Ophthalmology Beijing Friendship HospitalCapital Medical University Beijing 100050 China

Background Large drusen is a known risk factor for the development of late complications of age-related macular degeneration （AMD） and drusen reduction has been found by our previous study. To prospectively evaluate the efficacy and safety of prophylactic laser treatment in Chinese patients with bilateral soft drusen, we examined the structure and function of the macula 8 years after *** Ten patients with more than 10 soft drusen （〉125 mm） and best corrected visual acuity 〉20/25 in each eye participated in the study. One eye, with relatively more drusen, was exposed to an argon laser （514 nm） to achieve a barely visible retinal lesion. The contralateral eye was used as a control. Fluorescein angiography, Amsler tests,Fourier-domain optical coherence tomography and visual evoked potential tests were carried out 8 years *** No choroidal neovascularization was seen in the laser-treated eyes or control eyes. There were no significant differences in visual acuity or P100 latency and amplitude between the laser treated eyes and contralateral eyes （t=1.685,1.184; P〉0.05）. The thickness of the retinal pigment epithelium of the treated eyes was less than that of the contralateral eyes （t=-4.540; P 〈0.05）. The full retinal thickness in treated eyes was slightly, but insignificantly, reduced relative to contralateral eyes （t=-1.746; P 〉0.05）.Conclusions The treatment was associated with a reduction in retinal pigment epithelium thickness elevation compared with the contralateral eyes. macular function was not impaired.

关键词： drusen prophylactic laser treatment macular thickness

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Efficacy of Alzer<sup>®</sup>and Diamel, Nutritional Supplements, in the Prevention of Severe Diabetic macular Edema

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Open Journal of Ophthalmology 2020年第4期10卷 307-322页

作者： Juana Elvira Maciques Rodríguez Maria Emoé Pérez Muñoz Eduardo Cabrera Rode Laura Rosa Redondo Piño Raísa Beltrán Sainz Teresa González Calero Manuel Licea Puig Juan Lence Anta Rosaralis Paneca Santiesteban Yordanka Marrero Álvarez Eduardo Sanz Navares Instituto Nacional de Endocrinología Havana Cuba Hospital Universitario Salvador Allende Havana Cuba Instituto Nacional de Oncologia Havana Cuba Catalysis SL. Madrid Spain

Introduction: macular edema is the main cause of low vision in diabetic patients. Laser photocoagulation continues to be the treatment of choice in conjunction with the use of steroids and anti-angiogenics, but these ... 详细信息

Introduction: Macular edema is the main cause of low vision in diabetic patients. Laser photocoagulation continues to be the treatment of choice in conjunction with the use of steroids and anti-angiogenics, but these treatments include possible ocular complications. The nutritional supplement Alzer (whose primary active ingredient is Ginkgo biloba, a powerful antioxidant that acts on vascular factors and oxidative damage, which are two of the mechanisms implicated in the pathogenesis of diabetic macular edema), which has been used on other non-diabetic macular conditions, along with the Diamel nutritional supplement has been shown to be effective on glycemic control and could represent a treatment alternative for mild to moderate macular edema by reducing the thickness of the macular retina and preventing the progression of other more advanced clinical presentations that are harder to treat. Objective: Identify the effect of Alzer along with Diamel in reduction of the thickness of the macular retina among patients with mild to moderate diabetic macular edema. Materials and Methods: A phase II double-blind clinical trial was conducted in 64 patients with non-severe diabetic macular edema over the course of non-proliferative diabetic retinopathy, who attended the ophthalmology service of the Institute of Endocrinology of Havana from January 2016 to December 2016. The treatment was randomly assigned to two groups: one received Alzer plus Diamel (n

关键词： Alzer Diamel Ginkgo Biloba macular Edema macular thickness Nutritional Supplement

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