Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease:a meta-analysis

作     者：Samran Sheriff Ting Shen Sandra Abdal Danit Saks Mehdi Mirzaei Veer Gupta Nitin Chitranshi Yuyi You Angela Schultz Stuart L.Graham Vivek Gupta Samran Sheriff;Ting Shen;Sandra Abdal;Danit Saks;Mehdi Mirzaei;Veer Gupta;Nitin Chitranshi;Yuyi You;Angela Schultz;Stuart L.Graham;Vivek Gupta

作者机构：Macquarie Medical SchoolMacquarie UniversitySydneyNSWAustralia Save Sight InstituteThe University of SydneySydneyNSWAustralia School of MedicineDeakin UniversityMelbourneVICAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第11期

页      面：2504-2513页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：National Health and Medical Research Council (NHMRC) Australia (to VG) 

主　　题：Alzheimer’s disease foveal avascular zone macular thickness optical coherence tomography optical coherence tomography angiography retina retinal nerve fiber layer vessel density 

摘      要：Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the *** this metaanalysis,we aimed to investigate the association of various optical coherence tomography parameters with Alzheimer’s disease and whether retinal measurements can be used to diffe rentiate between Alzheimer’s disease and control *** databases including Google Schola r,Web of Science,and PubMed were systematically searched for published articles that evaluated retinal nerve fiber layer thickness and retinal microvascular network in Alzheimer’s disease and control ***-three studies(5850 participants,including 2249 Alzheimer’s disease patients and 3601controls) were included in this *** to controls,Alzheimer’s disease patients had a significantly lower global retinal nerve fiber layer thickness(standardized mean difference [SMD]=-0.79,95% confidence intervals [CI]:-1.03 to-0.54,P 0.00001) as well as each quadrant being thinner in Alzheimer’s disease versus *** macular paramete rs,values measured by optical coherence tomography were significantly lower in Alzheimer’s disease than controls for macular thickness(pooled SMD:-0.44,95% CI:-0.67 to-0.20,P=0.0003),foveal thickness(pooled SMD=-0.39,95% CI:-0.58 to-0.19,P 0.0001),ganglion cell inner plexiform layer(SMD=-1.26,95% CI:-2.24 to-0.27,P=0.01) and macular volume(pooled SMD=-0.41,95% CI-0.76 to-0.07,P=0.02).Analysis using optical coherence tomography angiography parameters revealed mixed results between Alzheimer’s disease and *** vessel density(pooled SMD=-0.42,95% CI:-0.68 to-0.17,P=0.0001) and deep vessel density(pooled SMD=-0.46,95% CI:-0.75 to-0.18,P=0.001) were found to be thinner in Alzheimer’s disease patients whereas the foveal avascular zone(SMD=0.84,95% CI:0.17-1.51,P=0.01) was larger in *** density and thickness of variou