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Circadian metabolism regulates the macrophage inflammatory response

Life Metabolism 2022年第3期1卷 224-233页

作者： Yulong Sun Wenjiao Jiang Tiffany Horng School of Life Sciences and Technology ShanghaiTech UniversityShanghai 201210China

macrophages are an integral part of the innate immune system and coordinate host defense to microbial infections,as well as shaping the remodeling response after tissue *** is now appreciated to be a powerful and pervasive regulator of the identity and function of *** exposure to microbial ligands,macrophage inflammatory activation and the associated induction of phagocytosis,inflammatory responses,and other host defense activities are supported by dynamic changes to cellular *** note,metabolic activity is robustly regulated in a circadian fashion,with many metabolic processes displaying peak activity in one phase of the circadian cycle and trough activity in an antiphase ***,we review recent findings suggesting that circadian metabolism influences macrophage activities and particularly the inflammatory ***,we summarize macrophage activities known to display time-of-day–dependent variation and their mechanistic ***,we review metabolic processes that have been shown to be rhythmically regulated in macrophages and discuss how such circadian metabolism affects or is likely to affect macrophage ***,we discuss the concept of entrainment of the macrophage clock,and consider how loss of rhythmic regulation of macrophage activities may contribute to pathophysiological conditions like shift work,obesity,and ***,we propose that circadian metabolism can be used to understand the rationale and mechanistic basis of dynamic regulation of inflammatory responses during infection.

关键词： macrophage metabolism circadian metabolism circadian rhythm immunometabolism circadian immunometabolism macrophage inflammatory responses

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