Circadian metabolism regulates the macrophage inflammatory response

作     者：Yulong Sun Wenjiao Jiang Tiffany Horng 

作者机构：School of Life Sciences and TechnologyShanghaiTech UniversityShanghai 201210China 

出 版 物：《Life Metabolism》 (生命（代谢（英文）)

年 卷 期：2022年第1卷第3期

页      面：224-233页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：T.H.was supported by funding from NSFC(32070895,92057105) MOST(2021YFA0804700) Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at Shanghai Tech University and Shanghai Clinical Research and Trial Center,Shanghai,China W.J.was supported by NSFC(32200715) 

主　　题：macrophage metabolism circadian metabolism circadian rhythm immunometabolism circadian immunometabolism macrophage inflammatory responses 

摘      要：Macrophages are an integral part of the innate immune system and coordinate host defense to microbial infections,as well as shaping the remodeling response after tissue *** is now appreciated to be a powerful and pervasive regulator of the identity and function of *** exposure to microbial ligands,macrophage inflammatory activation and the associated induction of phagocytosis,inflammatory responses,and other host defense activities are supported by dynamic changes to cellular *** note,metabolic activity is robustly regulated in a circadian fashion,with many metabolic processes displaying peak activity in one phase of the circadian cycle and trough activity in an antiphase ***,we review recent findings suggesting that circadian metabolism influences macrophage activities and particularly the inflammatory ***,we summarize macrophage activities known to display time-of-day–dependent variation and their mechanistic ***,we review metabolic processes that have been shown to be rhythmically regulated in macrophages and discuss how such circadian metabolism affects or is likely to affect macrophage ***,we discuss the concept of entrainment of the macrophage clock,and consider how loss of rhythmic regulation of macrophage activities may contribute to pathophysiological conditions like shift work,obesity,and ***,we propose that circadian metabolism can be used to understand the rationale and mechanistic basis of dynamic regulation of inflammatory responses during infection.