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Anthelmintic activity of Securidaca longepedunculata(Family:Polygalaceae)root extract in mice,in vitro and in vivo

Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 841-846页

作者： Adiele RC Fakae BB Isuzu IU Department of Anatomy and Cell Biology.Division of Biomedical Sciences College of MedicineUniversity of SaskatchewanSaskatoon.SK.S7N5E Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K OM7 Department of Veterinary Parasitology and Entomology Faculty of Veterinary MedicineUniversity of NigeriaNsukka Vice Chancellor's Office River State university of Science and TechnologyPort Harcourt Department of Veterinary Physiology and Pharmacology Faculty of Veterinary MedicineUniversity of NigeriaNsukka Deputy Vice Chancellor's Office.University of Nigeria Nsukka

Objective:To elucidate the pharmacological bases of oral administration of Securidaca longepedunculata(***) root extract as an anthelmintic in folkloric medicine. Methods:Albino mice were infected with infective third(L3) larval stage of Heligmosomoides polygyrus(***) by esophageal *** establishment of the adult worms in the intestine,the mice were treated with 0-2 000 mg/kg body weight(bw) of methanolic root extract of *** and 100 mg/kg bw of pyrantel embonate,the reference drug in vivo. Bioactivity and larvicidal effects of the extract were tested by exposing brine shrimps(Artemia salina) to 0.00-1.00 mg/mL and the L3 stage of Heligmosomoides contortus(***) and *** to 0.00-2.50 mg/mL of the extract in ***:The percentage yield of the extract was 7.13%w/w dry *** brine shrimps toxicity bioassay resulted in an LC_(50) of 74.18 μ g/*** extract had a significant,dose-dependent larvicidal effect on the L3 stage of *** and *** with the terminal effect of 75%and 70%at the highest exposure concentrations,*** extract however,did not affect the number of worm eggs per gram(epg) of fecal materials(P<0.05) and total worm burden(twb) of adult *** in infected *** with pyrantel embonate significant reduced both the fecal egg count and twb to 0 compared to the untreated control(P<0.05).Conclusions:These results indicate that *** root extract contains potent bioactive compounds and has larvicidal effect on L3 stage of *** and ***,substantiating its use as anthelmintic in alternative medicine.

关键词： Anthelmintic Securidaca longepedunculata Haemonchus contortus Heligmosomoides polygyrus Brine shrimps Larvicidal Fecal egg count

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