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Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

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World Journal of Gastroenterology 2019年第26期25卷 3359-3369页

作者： Guo-Qing Zhang Li-Ping Zhong Nuo Yang Yong-Xiang Zhao National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University

Aptamers are a class of single oligonucleotide molecules(DNA or RNA)that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment *** selected aptamers are capable of specifically binding to different targeting molecules,which is achieved by the three-dimensional structure of *** are similar in function to monoclonal antibodies,and therefore,they are also referred to as"chemical antibodies".Due to their high affinity and specificity and low immunogenicity,aptamers are topics of intense interest in today's biological targeting research especially in tumor *** not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor *** experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for *** paper summarizes the structure,characteristics,and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer.

关键词： Aptamer Systemic evolution of ligands by exponential enrichment Liver cancer Outlook

Half-sandwich rhodium poly-chalcogenide complexes and a carbon insertion into Te-Te bond

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Chinese Science Bulletin 2002年第3期47卷 187-189页

作者： Qingan Kong Guoxin Jin Fudan Univ Dept Chem Shanghai 200433 Peoples R China

Treatment of CptRh(PMe3)Cl2(1) (Cpt=5η-tBu2C5H3) with [Et4N]2Se6 in DMF solution leads to the for-mation of cyclo-tetraselenido half-sandwich rhodium com-plexes CptRh(PMe3)(Se4) (2). The elimination of 2 with ex-cess of nBu3P results in cyclo-diselenido rhodium complex CptRh(PMe3)(Se2) (3). 1 reacts with [nBu4N]2Te5 in DMF solution to yield cyclo-ditellurido rhodium complex CptRh (PMe3)(Te2) (4) in which carbon atom from CH2C12 can be inserted into Te-Te bond to form CptRh(PMe3)(TeCH2Te) (5). The new complexes 2-5 have been characterized by their IR, EI-MS, and 1H, 13C, 31P, 103Rh NMR spectra as well as ele-mental analysis.

关键词： half-sandvrich rhodium complexes polyselenido ligands polytellurido ligands insertion reaction 77 Se-NMR.

Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols:An efficient access to homoallylic alcohols with a chiral quaternary center

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Science China Chemistry 2010年第9期53卷 1899-1906页

作者： ZHANG Qi,ZHU Shou-Fei,CAI Yan,WANG Li-Xin & ZHOU Qi-Lin State Key Laboratory and Institute of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin China

Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed.A series of homoallylic alcohols with a chiral quaternary center were produced in high yields(up to 97%) and high enantioselectivities(up to 95% ee).The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.

关键词： asymmetric hydrovinylation chiral spiro phosphorus ligands functionalized olefins chiral quaternary center

Advances in modeling of biomolecular interactions

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Acta Pharmacologica Sinica 2004年第1期 3-10页

作者： Cong-zhong CAI, Ze-rong LI, Wan-lu WANG, Yu-zong CHENDepartment of Applied Physics, Chongqing University, Chongqing 400044, China Bioprocessing Technology Centre Department of Computational Science, National University of Singapore, Singapore 117543

Modeling of molecular interactions is increasingly used in life science research and biotechnology development. Examples are computer aided drug design, prediction of protein interactions with other molecules, and simulation of networks of biomolecules in a particular process in human body. This article reviews recent progress in the related fields and provides a brief overview on the methods used in molecular modeling of biological systems.

关键词： computer simulation computer-aided design ligands protein conformation

The Preparation and Crystal Structure of Ammonium Oxalatooxodiperoxotungstate(NH_4)_2[WO(O_2)_2(C_2O_2)]

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Chinese Science Bulletin 1994年第22期39卷 1886-1889页

作者：石晓波李春根巫生华陈健谢高阳 Department of Chemistry Jiangxi Normal University Nanchang 330027 PRC Center of Analysis and Measurement Fudan University Shanghai 200433 PRC

In H2O2 solution of different concentrations or various pH, Mo can form various kinds of peroxodydates with different polymeric states and structures of most of them have been *** have also been successfully used as o... 详细信息

关键词： peroxotungstate salts oxalato ligands crystal structure.

STUDY ON THE EFFECTS OF THE ANTITUMOR DRUG cis-DDP ON THE PHASE BEHAVIOR OF DPPC LIPOSOMES AND MOLECULAR MECHANISM OF THE INTERACTION

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Chinese Science Bulletin 1991年第2期36卷 149-153页

作者：沈子威孙中平赵南明 Department of Biological Science and Biotechnology Tsinghua University Beijing 100084 PRC

Cis-diamminedichloroplatinum (Ⅱ) (cis-DDP, also cisplatin) is the first heavy metal coordination compound to be the leading and most widely used antitumor *** molecular structures of cis-DDP and trans-DDP (inactive) ... 详细信息

关键词： cis-DDP DPPC liposomes ammine ligands phosphofipids.

Poly(Ethylene Oxide) Mediated Synthesis of Sub-100-nm Aluminum Nanocrystals for Deep Ultraviolet Plasmonic Nanomaterials

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CCS Chemistry 2020年第4期2卷 516-526页

作者： Shuang Yang Shaoyong Lu Yang Li Hua Yu Linxia He Tianmeng Sun Bai Yang Kun Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012 The First Bethune Hospital and Institute of Immunology Jilin UniversityChangchun 130021 State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130012

Aluminum nanocrystals(Al NCs)are sustainable plasmonic nanomaterials with unique localized surface plasmonic resonance(LSPR)in the ultraviolet(UV)*** synthesis of sub-100-nm Al NCs remains a considerable challenge due to the lack of effective ligands to control their ***,we describe a precise size-controlled synthesis of small colloidal Al NCs(25–100 nm)with strong and tunable LSPR peak from 250 to 372 nmin the UV spectral region by the use of poly(ethylene oxide)(PEO)as a polydentate surface ligand.

关键词： aluminum nanocrystal UV plasmonics polymer ligands size-controlled synthesis poly (ethylene) oxide

Targeted immunotherapy for non-small cell lung cancer

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World Journal of Clinical Oncology 2014年第2期5卷 39-47页

作者： Monali Vasekar Xin Liu Hong Zheng Chandra P Belani Penn State Hershey Cancer Institute Penn State University College of Medicine

Targeted therapies that deliver the expected anti-tumor effects while mitigating the adverse effects are taking the cancer world by storm. The need for such therapies in non-small cell lung cancer(NSCLC), where systemic cytotoxic chemotherapies still remain the backbone of management, is felt more than ever before. Runway success of immunotherapies such as Ipilimumab for melanoma has brought excitement among oncologists. Immune-based treatments are in various stages of evaluation for NSCLC as well. Immunotherapies using strategies of antigen based or cell based vaccines, and blocking immune checkpoints are of substantial interest. Meaningful clinical responses are yet to be reaped from these new treatment modalities.

关键词： Immunotherapy Non-small cell lung cancer Programmed death-1 Programmed death ligands 1 Cytotoxic T-Lymphocyte Antigen-4

A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 367-370页

作者： Waleed Mahmoud Al Momani Ziyad Ahmed Taha Abdulaziz Mahmoud Ajlouni Qasem Mohammad Abu Shaqra Muaz Al Zouby Department of Allied Medical Sciences Al Balqa' Applied University Department of Applied Chemical Sciences Jordan University of Science and Technology Medical Diagnostic Laboratories

Objective:To establish the antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand ***:(N,N'-bis(l-naphthaldimine)-o-phenylenediamine)was prepared from the condensation of 2—hydroxy-1-naphthaldehyde with o-phenylenediamine in a molar ratio of 2:*** antimicrobial activity of the resultant Ln(Ⅲ)complexes was investigated using agar well diffusion and micro-broth dilution techniques;the latter was used to establish the minimum inhibitory concentrations for each compound ***:Most of Ln(Ⅲ)complexes were found to exhibit antibacterial activities against a number of pathogenic bacteria with MICs ranging between 1.95-250.00μg/*** aureus was the most susceptible bacterial species to[LaL(NO_3)_2(H_2O)](NO_3)complex while Shigella dysenteriae and Escherichia coli required a relatively higher MIC(250μg/mL).Trie complexes La(Ⅲ)and Pr(Ⅲ)were effective inhibitors against Staphylococcus aureus,whereas Sm(Ⅲ)complex was effective against Serratia *** the other hand,Gd(Ⅲ),La(Ⅲ)and Nd(Ⅲ)were found to be more potent inhibitors against Pseudompnas aeruginosa than two of commonly used *** remaining Ln(Ⅲ)complexes showed no remarkable activity as compared to the two standard drugs ***:Tetradentate Schiff base ligand L and its complexes could be a potential antibacterial compounds after further investigation.

关键词： Antimicrobial Biomolecules Organics Synthetic ligands