Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols:An efficient access to homoallylic alcohols with a chiral quaternary center
Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols:An efficient access to homoallylic alcohols with a chiral quaternary center作者机构：State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin China
出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)
年 卷 期：2010年第53卷第9期
页 面：1899-1906页
核心收录：
学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
基 金：the National Natural Science Foundation of China the National Basic Research Program of China (973 Program) (2006CB806106, 2010CB833300) the Ministry of Health (2009ZX09501-017) "111" Project of the Ministry of Education of China (B06005) for financial support
主 题：asymmetric hydrovinylation chiral spiro phosphorus ligands functionalized olefins chiral quaternary center
摘 要：Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed.A series of homoallylic alcohols with a chiral quaternary center were produced in high yields(up to 97%) and high enantioselectivities(up to 95% ee).The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.
维普期刊数据库
同方期刊数据库