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Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis

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International Journal of Oral Science 2020年第2期12卷 162-171页

作者： Lingjun Li Han Jiang Rixin Chen Jing Zhou Yin Xiao Yangheng Zhang Fuhua Yan Nanjing Stomatological Hospital Medical School of Nanjing UniversityNanjingChina People’s Hospital of Suzhou National New&Hi-Tech Industrial Development Zone SuzhouChina The Affiliated Stomatological Hospital Zhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceZhejiang University School of StomatologyHangzhouChina Institute of Health and Biomedical Innovation&the Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyBrisbaneAustralia

Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for ***β-defensin 3,a broad-spectrum antimicrobial peptide has been proven to have a variety of biological functions in periodontitis;however,relatively few reports have addressed the effects of human periodontal ligament cells(h PDLCs)on osteogenic *** this study,we evaluated the osteogenic effects of h PDLCs with an adenoviral vector encoding humanβ-defensin 3 in an inflammatory *** humanβ-defensin 3 gene-modified rat periodontal ligament cells were transplanted into rats with experimental periodontitis to observe their effects on periodontal bone *** found that the humanβ-defensin 3 gene-modified h PDLCs presented with high levels of osteogenesis-related gene expression and calcium ***,the p38 MAPK pathway was activated in this *** vivo,humanβ-defensin 3 gene-transfected rat PDLCs promoted bone repair in SD rats with periodontitis,and the p38 mitogen-activated protein kinase(MAPK)pathway might also have been *** findings demonstrate that humanβ-defensin 3 accelerates osteogenesis and that humanβ-defensin 3 gene modification may offer a potential approach to promote bone repair in patients with periodontitis.

关键词： period periodontal ligament

Tracing PRX1+cells during molar formation and periodontal ligament reconstruction

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International Journal of Oral Science 2022年第1期14卷 51-59页

作者： Xuyan Gong Han Zhang Xiaoqiao Xu Yunpeng Ding Xingbo Yang Zhiyang Cheng Dike Tao Congjiao Hu Yaozu Xiang Yao Sun Department of Implantology School&Hospital of StomatologyTongji UniversityShanghaiChina Shanghai Engineering Research Center of Tooth Restoration and Regeneration ShanghaiChina Shanghai East Hospital School of Life Sciences and TechnologyTongji UniversityShanghaiChina

Neural crest-derived mesenchymal stem cells(MSCs)are known to play an essential function during tooth and skeletal ***1+cells constitute an important MSC subtype that is implicated in ***,their potential function in tooth development and regeneration remains *** the present study,we first assessed the cell fate of PRX1+cells during molar development and periodontal ligament(PDL)formation in ***,single-cell RNA sequencing analysis was performed to study the distribution of PRX1+cells in PDL *** behavior of PRX1+cells during PDL reconstruction was investigated using an allogeneic transplanted tooth *** PRX1+cells are spatial specific and can differentiate into almost all types of mesenchymal cells in first molars,their distribution in third molars is highly *** PDL formation is associated with a high number of PRX1+cells;during transplanted teeth PDL reconstruction,PRX1+cells from the recipient alveolar bone participate in angiogenesis as ***,PRX1+cells are a key subtype of dental MSCs involved in the formation of mouse molar and PDL and participate in angiogenesis as pericytes during PDL reconstruction after tooth transplantation.

关键词： ligament molar assessed

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao Jiang Siyuan Zhao Dong Xie Qing Chen Qi Zhao Hao Wu Jian Luo Lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

Calcifying fibrous tumor originating from the gastrohepatic ligament that mimicked a gastric submucosal tumor: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2802-2807页

作者： Byung Soo Kwan Dae Hyeon Cho Division of Gastroenterology and Hepatology Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicine

BACKGROUND Calcifying fibrous tumor (CFT) is a rare, benign soft tissue tumor usually occurring in children or young adults. Gastrohepatic ligament CFT with adhesion to the stomach is very rare. We present a case here. CASE SUMMARY A 25-year-old woman visited our hospital with abdominal pain. Computed tomography and endoscopy were performed, and a gastric submucosal tumor (SMT) with a size of 6.7 cm × 2.7 cm was detected, so endoscopic ultrasonography-guided fine needle biopsy was performed. The tumor was not diagnosed histologically, so surgical resection was planned and performed. The histopathologically confirmed mass size was 6.5 cm × 4.0 cm × 1.0 cm, and a calcified fibrous tumor that originated at the gastrohepatic ligament and adhered to the lesser curvature of the gastric antrum was identified. CONCLUSION Gastrohepatic ligament CFT is a very rare benign tumor. Since this disease may be confused with gastric SMT, the possibility of CFT should be kept in mind during clinical assessment of this disease.

关键词： Calcifying fibrous tumor Gastrohepatic ligament Submucosal tumor Case report

Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament-bone interface

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Biosurface and Biotribology 2021年第4期7卷 187-205页

作者： Nan Jiang Mao Mao Xiao Li Weijie Zhang Jiankang He Dichen Li State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’anShaanxiChina Department of Surgical Oncology Shaanxi Provincial People’s Hospital(Third Hospital of Medical College of Xi’an Jiaotong University)Xi’anShaanxiChina NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi’an Jiaotong UniversityXi’anShaanxiChina Department of Knee Joint Surgery Hong Hui HospitalHealth Science CenterXi’an Jiaotong UniversityXi’anShaanxiChina

The natural ligament-bone interface features gradient changes in matrix composition,architecture and cell phenotype,which play critical roles in reliable ligament fixation and smooth loading *** such organisations in artificial composite tissue-engineering scaffolds is important for realising functional fixation between ligament implants and host ***,the authors aim to provide a comprehensive review on the latest strategies to fabricate biomimetic composite scaffolds for the regeneration of ligament-to-bone *** biomimetic composite scaffolds are divided into stratified and gradient scaffolds,which are characterised as layer-specific and continuous changes,respectively,in scaffold materials and/or *** strategies for different types of composite scaffolds are *** effects of material/structural changes on cellular morphology,cell differentiation,in vivo osteointegration and multi-tissue interface regeneration are ***,the potential challenges and future perspectives in engineering biomimetic composite scaffolds for ligament-bone interface regeneration are discussed.

关键词： biofabrication biomimetic composite scaffolds gradient scaffolds ligament stratified scaffolds

Overview of noncoding RNAs involved in the osteogenic differentiation of periodontal ligament stem cells

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World Journal of Stem Cells 2020年第4期12卷 251-265页

作者： Wei Qiu Bu-Ling Wu Fu-Chun Fang Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

Periodontal diseases are infectious diseases that are characterized by progressive damage to dental support *** major goal of periodontal therapy is to regenerate the periodontium destroyed by periodontal *** periodontal ligament(PDL)tissue possesses periodontal regenerative properties,and periodontal ligament stem cells(PDLSCs)with the capacity for osteogenic differentiation show strong potential in clinical application for periodontium repair and *** RNAs(ncRNAs),which include a substantial portion of poly-A tail mature RNAs,are considered“transcriptional noise.”Recent studies show that ncRNAs play a major role in PDLSC differentiation;therefore,exploring how ncRNAs participate in the osteogenic differentiation of PDLSCs may help to elucidate the underlying mechanism of the osteogenic differentiation of PDLSCs and further shed light on the potential of stem cell transplantation for periodontium *** this review paper,we discuss the history of PDLSC research and highlight the regulatory mechanism of ncRNAs in the osteogenic differentiation of PDLSCs.

关键词： Noncoding RNAs Periodontal regeneration Periodontal ligament stem cells Osteogenic differentiation

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes

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World Journal of Gastroenterology 2013年第11期19卷 1834-1840页

作者： Hideki Fujii Naoki Ohnishi Kazuho Shimura Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Tatsuro Kobata Kanji Yamaguchi Yoshito Itoh Department of Internal Medicine Aiseikai Yamashina HospitalShichouno-choTakehanaYamashinakuKyoto 602-8086Japan Department of Gastroenterology and Hepatology Uji Tokushukai HospitalKyoto 611-0042Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan

Autoimmune hepatitis(AIH) is a necroinflammatory liver disease of unknown *** disease is characterized histologically by interface hepatitis,biochemically by increased aspartate aminotransferase and alanine aminotransferase levels,and serologically by increased autoantibodies and immunoglobulin G *** we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes(HLLNs,diameter,50 mm).Based on these observations,the differential diagnoses were AIH,lymphoma,or Castleman's *** biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute *** node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration;immunohistochemical examination excluded the presence of lymphoma ***,he was administered corticosteroid therapy:after 2 mo,the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in *** could not find AIH cases with such enlarged lymph nodes(diameter,50 mm) in our literature ***,we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated,humoral immune response in AIH.

关键词： Autoimmune hepatitis Humoral immune response Hepatoduodenal ligament lymph nodes Corticosteroid Hepatomegaly

Immunohistochemical evaluation for outflow reconstruction using opened round ligament in living donor right posterior sector graft liver transplantation: A case report

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World Journal of Gastroenterology 2016年第34期22卷 7851-7856页

作者： Yukihiro Sanada Yasunaru Sakuma Hideki Sasanuma Atsushi Miki Takumi Katano Yuta Hirata Noriki Okada Naoya Yamada Yoshiyuki Ihara Taizen Urahashi Naohiro Sata Yoshikazu Yasuda Koichi Mizuta Department of Transplant Surgery Jichi Medical University Department of Surgery Jichi Medical University

Utilizing the opened round ligament as venous grafts during liver transplantation is useful but controversial,and there are no pathological analyses of this procedure. Herein,we describe the first reported case of a pathological analysis of an opened round ligament used as a venous patch graft in a living donor liver transplantation(LDLT). A 13-year-old female patient with biliary atresia underwent LDLT using a posterior segment graft from her mother. The graft had two hepatic veins(HVs),which included the right HV(RHV; 15 mm) and the inferior RHV(IRHV; 20 mm). The graft RHV and IRHV were formed into a single orifice using the donor's opened round ligament(60 mm × 20 mm) as a patch graft during bench surgery; it was then anastomosed end-to-side with the recipient inferior vena cava. The recipient had no post-transplant complications involving the HVs,but she died of septic shock with persistent cholangitis and jaundice 86 d after LDLT. The HV anastomotic site had no stenosis or thrombus on autopsy. On pathology,there was adequate patency and continuity between the recipient's HV and the donor's opened round ligament. In addition,the stains for CD31 and CD34 on the inner membrane of the opened round ligament were positive. Hepatic venous reconstruction using the opened round ligament as a venous patch graft is effective in LDLT,as observed on pathology.

关键词： Opened round ligament Venous patch graft Hepatic venous reconstruction Living donor liver transplantation All-in-one venoplasty

Follicular dendritic cell sarcoma detected in hepatogastric ligament:A case report and review of the literature

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World Journal of Clinical Cases 2019年第1期7卷 116-121页

作者： Wen-Xin Yan You-Xi Yu Ping Zhang Xing-Kai Liu Yan Li Department of Hepatobiliary and Pancreatic Surgery the First Hospital of Jilin University Department of Surgery School of Medicine University of Louisville

The most common organ where follicular dendritic cell sarcoma(FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that FDCS occurs in the hepatogastric ligament. To our knowledge, there is no such case that has been reported previously. A 47-year-old male patient was found to have an intraabdominal mass during an annual physical examination. Computed tomography showed a 4.2 cm × 4.1 cm mass located at the lesser curvature of the stomach, above the pancreas. During operation, a tumor mass was found in the hepatogastric ligament and a radical resection was performed. The tumor was diagnosed as FDCS by pathology and immunohistochemical testing. The patient had a favorable recovery, and no obvious abnormality was found 3 months postoperation.

关键词： Follicular dendritic cell sarcoma Hepatogastric ligament Pathology Immunohistochemistry Computed tomography Case report