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Antifertility effects of methanolic pod extract of Albizzia lebbeck (L.) Benth in male rats

Asian Journal of Andrology 2004年第2期6卷 155-159页

作者： R. S. Gupta J. B. S.Kachhawa R. Chaudhary Reproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India

Aim: To evaluate the antifertility activity of the methanolic pod extract of Albizzia lebbeck (L.) Benth in male albino rats. Methods: The methanolic pod extract of Albizzia lebbeck was administrated orally for 60 days at 50, 100 and 200 mg·kg-1·day-1 to male albino rats. Sperm motility and density in cauda epididymides were assessed. Biochemical and histological analysis were performed in blood samples and reproductive organs. Results: A. lebbeck pod extract brought about a significant decrease in the weights of testis, seminal vesicles, epdidymis and ventral prostate. The sperm motility and density were significantly reduced. There was a marked reduction in the numbers of primary spermatocytes, secondary spermatocytes and spermatids. The Sertoli cell count as well as its cross sectional surface area were significantly decreased. The leydig cell nuclear area and the number of mature leydig celis were also significantly decreased. The protein, glycogen and cholesterol content of the testis, the fructose in the seminal vesicles and protein in the epididymis were significantly decreased. The RBC and WBC counts, haemoglobin, haematocrit and blood sugar were within the normai range. Conclusion: The methanolic extract of A. lebbeck pods causes spermatogenic arrest in male albino rats.

关键词： Albizzia lebbeck sertoli celis spermatogonia spermatocytes leydig celis

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Molecular identity, expression and functional analysis of interleukin-1α and its isoforms in rat testis

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Asian Journal of Andrology 2004年第2期6卷 149-153页

作者： T. Sultana K. V. Svechnikov K. Gustafsson A. Wahlgren E. Tham G. Weber O. Soder Pediatric Endocrinology Unit Department of Woman and Child Health Centre for Molecular Medicine and Tumor Biochemistry Karolinska Institute and Hospital S-17176 Stockholm Sweden Department of Biological and Biomedical Sciences Faculty of Health Sciences Aga Khan University Karachi- 74800 Pakistan Department of Chemistry and Biomedical Sciences Vniversity of Kalmar SE-391 82 Kalmar Sweden

Interleukin-1α (IL-1α) is a proinflammatory cytokine that has also been found to act as a paracrine mediator involved in the regulation of testicular functions. The present review provides an overview of the role of IL 1α in testicular physiology. Bioactive IL-1α isolated from adult rat testis was found to consist of three distinct immunoreactive protein species with apparent sizes of 45, 24 and 19 kDa. These isoforms showed bioactivity in a thymocyte proliferation and steroidogenesis assays with different biopotencies. The background of the molecular heterogeneity and processing, secretion and regulation of the isoforms of testicular IL-1α are discussed. All three isoforms have been found to be secreted into the testis tubular lumen and interstitial space. We have provided evidence that IL-1α is a paracrine factor that may be of importance in, e.g., the regulation of leydig cell steroidogenesis. Pathophysiologically, testicular IL-1α may contribute to testicular relapse of acute lymphocytic leukemia in boys.

关键词： IL-1α spermatogenesis testis Sertoli celis leydig celis calpain

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