Antifertility effects of methanolic pod extract of Albizzia lebbeck (L.) Benth in male rats
Antifertility effects of methanolic pod extract of Albizzia lebbeck (L.) Benth in male rats作者机构：Reproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2004年第6卷第2期
页 面：155-159页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Albizzia lebbeck sertoli celis spermatogonia spermatocytes leydig celis
摘 要：Aim: To evaluate the antifertility activity of the methanolic pod extract of Albizzia lebbeck (L.) Benth in male albino rats. Methods: The methanolic pod extract of Albizzia lebbeck was administrated orally for 60 days at 50, 100 and 200 mg·kg-1·day-1 to male albino rats. Sperm motility and density in cauda epididymides were assessed. Biochemical and histological analysis were performed in blood samples and reproductive organs. Results: A. lebbeck pod extract brought about a significant decrease in the weights of testis, seminal vesicles, epdidymis and ventral prostate. The sperm motility and density were significantly reduced. There was a marked reduction in the numbers of primary spermatocytes, secondary spermatocytes and spermatids. The Sertoli cell count as well as its cross sectional surface area were significantly decreased. The Leydig cell nuclear area and the number of mature Leydig celis were also significantly decreased. The protein, glycogen and cholesterol content of the testis, the fructose in the seminal vesicles and protein in the epididymis were significantly decreased. The RBC and WBC counts, haemoglobin, haematocrit and blood sugar were within the normai range. Conclusion: The methanolic extract of A. lebbeck pods causes spermatogenic arrest in male albino rats.
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