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DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

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Military Medical Research 2022年第1期9卷 1-11页

作者： Gang Xu Yi-Kun Shi Bin-Da Sun Lu Liu Guo-Ji E Shu He Jian-Yang Zhang Bao Liu Qiu Hu Jian Chen Yu-Qi Gao Er-Long Zhang Institute of Medicine and Equipment for High Altitude Region College of High Altitude Military MedicineArmy Medical UniversityChongqing 400038China Key Laboratory of Extreme Environmental Medicine Ministry of Education of ChinaChongqing 400038China Key Laboratory of High Altitude Medicine People's Liberation ArmyChongqing 400038China

Background:Studies have revealed the protective effect of DL-3-n-butylphthalide(NBP)against diseases associated with ischemic ***,the role of NBP in animals with hypobaric hypoxia has not been *** study investigated the effects of NBP on rodents with acute and chronic hypobaric ***:Sprague-Dwaley rats and Kunming mice administered with NBP(0,60,120,and 240 mg/kg for rats and 0,90,180,and 360 mg/kg for mice)were placed in a hypobaric hypoxia chamber at 10,000 m and the survival percentages at 30 min were ***,the time and distance to exhaustion of drug-treated rodents were evaluated during treadmill running and motor-driven wheel-track treadmill experiments,conducted at 5800 m for 3 days or 20 days,to evaluate changes in physical *** frequency of active escapes and duration of active escapes were also determined for rats in a shuttle-box experiment,conducted at 5800 m for 6 days or 27 days,to evaluate changes in learning and memory *** levels were measured in the gastrocnemius muscle and malonaldehyde(MDA),superoxide dismutase(SOD),hydrogen peroxide(H_(2)O_(2)),glutathione peroxidase(GSH-Px),and lactate were detected in sera of rats,and routine blood tests were also ***:Survival analysis at 10,000 m indicated NBP could improve hypoxia tolerance *** time and distance to exhaustion for mice(NBP,90 mg/kg)and time to exhaustion for rats(NBP,120 and 240 mg/kg)significantly increased under conditions of acute hypoxia compared with control *** treatment also significantly increased the time to exhaustion for rats when exposed to chronic ***,240 mg/kg NBP significantly increased the frequency of active escapes under conditions of acute ***,the levels of MDA and H_(2)O_(2) decreased but those of SOD and GSH-Px in the sera of rats increased under conditions of acute and chronic ***,ATP levels in the gastrocnemius muscle significantly incre

关键词： DL-3-n-butylphthalide Hypobaric hypoxia Physical function learning and memory function Oxidative stress Energy metabolism

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The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury

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Neural Regeneration Research 2014年第7期9卷 688-692页

作者： Dong Sun Department of Neurosurgery Medical College of Virginia Campus Virginia Commonwealth University

Traumatic brain injury （TBI） is the leading cause of death and disability of persons under 45 years old in the United States, affecting over 1.5 million individtials each year. It had been th ought that recovery from such injuries is severely limited due to the inability of the adult bra in to replace damaged neurons. However, recent studies indicate that the mature mammalian central nervous system （CNS） has the potential to replenish damaged neurons by proliferation and neuronal differentiation of adult neural stem/progenitor cells residing in the neurogenic regions in the brain. Furthermore, increasing evidence indicates that these endogenous stem/ progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. In support of this notion, heightened levels of cell proliferation and neurogenesis have been ob- served in response to brain trauma or insults suggesting that the brain has the inherent potential to restore populations of damaged or destroyed neurons. This review will discuss the potential functions of adult neurogenesis and recent development of strategies aiming at harnessing this neurogenic capacity in order to repopulate and repair the injured brain.

关键词： traumatic brain injury adult neurogenesis neural stem cells cell proliferation hippo-campus subventricular zone learning and memory function regeneration cognition

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Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia

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Neural Regeneration Research 2018年第8期13卷 1384-1389页

作者： Xiao-Qiao Zhang Li Li Jiang-Tao Huo Min Cheng Lin-Hong Li Department of General Medicine & Neurology Taihe Hospital Hubei University of Medicine Department of Pharmacy Taihe Hospital Hubei University of Medicine

Repetitive transcranial magnetic stimulation （rTMS） is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown, In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were ad- ministered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1,33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotroph- ic factor （BDNF）-immunoreactive cells in the hippocampal CA1 region, rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia, The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA 1 region.

关键词： nerve regeneration cholinergic system neurotrophic factor hippocampal CA1 region learning and memory function repetitivetranscranial magnetic stimulation vascular dementia neural regeneration

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Tongdu Tiaoshen Acupuncture Method for Promoting Hippocampal Nerve Repair and Regeneration and Improving learning and memory Dysfunction in Stroke Model Rats

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Medicinal Plant 2021年第2期12卷 95-98,101页

作者： Jin XIE Jingping MU Zhongmin HUANG Fangfang YANG Wanfen WANG Jimin LIU Jing TAO Lidian CHEN Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Fujian University of Traditional Chinese Medicine Fuzhou 350000 China

[Objectives]To evaluate the effects of Tongdu Tiaoshen Acupuncture method on improving learning and memory function and hippocampal nerve regeneration and repair after stroke.[Methods]Animal models of cognitive impairment in the recovery phase of cerebral infarction in rats were prepared,and rats were randomly divided into control group,model group,donepezil group,and acupuncture *** water maze experiment was carried out to evaluate learning and memory *** staining,BrdU and DCX immunofluorescence staining were used to observe the number and morphological structure of neuronal pyramidal and granular cells in the dentate gyrus(DG)area of the hippocampus,as well as the proliferation and differentiation of neural progenitor *** method was used to detect cell apoptosis.[Results]Before intervention,the scores and ELP of the model group,donepezil group and acupuncture group were significantly higher than those of the blank group(P0.05),but it was still significantly higher than the blank group(P<0.05).The results of BrdU and DCX immunofluorescence staining showed that there were only a few BrdU positive cells and DCX protein in the hippocampal DG area of mice in the blank group,and the positive cells in the model group were significantly increased(P<0.05);donepezil group and acupuncture group showed significant increase compared with the model group(P<0.05);compared with the blank group,the number of neurons in the hippocampal DG area of each group was significantly reduced(P<0.01),and the neuronal apoptosis index was significantly increased(P<0.01);compared with the blank group,the number of neurons in the hippocampal DG area of

关键词： Tongdu Tiaoshen Acupuncture Stroke Cognitive impairment learning and memory function Hippocampal nerve

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