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lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial

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Journal of Integrative Medicine 2020年第5期18卷 409-415页

作者： Toktam Sadat Firoozeei Majid Barekatain Mehrdad Karimi Arman Zargaran Shahin Akhondzadeh Hossein Rezaeizadeh Deportment of Persion Medicine School of Persian MedicineTehron University of Medical SciencesTehran ***Iran Department of Psychiatry 5chool of Medicine.lsfahan University of Medical Sctences.Isfahan ***Iran Depertment of Trditioniod Phormay School of Persion Medicine.Tehran Untiversity of Medical Sciences.Tehran *** Iran Pschitric Research Center Roozbeh HospitalTehran University of Medical Sctences.Tehran ***Iran

Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such ***: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious ***, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 *** outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two ***: Fifty-six participants with MDD and anxious distress were randomly assigned to two *** depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious *** registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.

关键词： Persian medicine Traditional medicine Anxiety Depression Phytotherapy lavender Dodder Citalopram

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A further study of the kinetics and optimization of the essential oil hydrodistillation from lavender flowers

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Chinese Journal of Chemical Engineering 2021年第1期34卷 126-130页

作者： Aleksandra Perovic Mihajlo Z.Stankovic Vlada B.Veljkovic Milan D.Kostic Olivera S.Stamenkovic University of Niš Faculty of TechnologyBulevar oslobodjenja 124Leskovac 16000Serbia The Serbian Academy of Sciences and Arts Knez Mihailova 35Belgrade 11000Serbia

Hydrodistillation has commonly been used to recover essential oil from various plant materials,including lavender(Lavandula officinalis) *** main objectives of the present study were to model the kinetics of the lavender essential oil(LEO) hydrodistillation using a phenomenological model,to evaluate the statistical significance of the hydromodule and hydrodistillation time on LEO yield combining a 4~2 full factorial design with the response surface methodology,to model statistically LEO yield by multiple non-linear regression and to determine the optimal process conditions that provided the maximum LEO *** fast-essential oil distillation(washing stage) in the initial period and the slow diffusion stage until the saturation occurring simultaneously were observed,justifying the use of the phenomenological *** increasing the hydromodule,the saturation LEO yield and the washable fraction of the LEO decreased while the washing and diffusion rate constants *** of the LEO oil yield and the hydrodistillation kinetics is important from the techno-economical point of view.

关键词： Essential oil lavender Lavandula officinalis L. Kinetics Hydrodistillation Modeling

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Effects of lanthanum on the growth and essential oil components of lavender under osmotic stress

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Journal of Rare Earths 2018年第8期36卷 891-897页

作者： Liyun Zhu Linzhen Song Yongsheng Gao Junqing Qian Xiaodong Zhang Sufang Li College of Modem Science and Technology China Jiliang University Hangzhou 310018 China Anhui Hanfang Bio-tech Co. Ltd. Huaibei 235000 China National & Local United Engineering Lab of Quality Controlling Technology and Instrumentation for Marine Food China Jiliang University Hangzhou 310018 China College of Biotechnology and Bioengineering Zhejiang University of Technology Hangzhou 310012 China

The effects of lanthanum on growth, soluble sugar content, essential oil contents and quality were studied in lavender plant（Lavandula Angustifolia Mill, Variety 701） under osmotic stress by means of PEG-6000 solution. The results show that osmotic stress could reduce the growth rate of lavender, and increase the content of SSC（soluble sugar concentration） to some extent. Compared with control group,the contents of essential oil in flowers and leaves respectively increase by 45.6% and 48.3% in the osmotic stress group induced by 15% PEG-6000. However, the presence of lanthanum can make the contents of essential oil in the flowers and leaves of stressed lavender plants enhance by 19.4% and 18.6%, respectively. Under osmotic stress, the relative contents of four kinds of lavender essential oil compositions of camphor, linalool, linalyl acetate and lavandulol acetate in the lavender flowers were successively 22.63%,0.61%,25.46%,7.03%,and 20.17%,0.62%,20.72%,10.80%,respectively in the presence and absence of lanthanum. The contents of all four main components of lavender essential oils meet the requirements of the national standard under osmotic stress in the presence of lanthanum. However, in the absence of lanthanum, the contents of linalyl acetate and lavandulol acetate does not meet the requirements of the national standard under osmotic stress. Moreover, the contents of five components of borneol, camphor,eudesmol, caryophyllene oxide and bicyclic sesquiphellandrene from the essential oil of lavender leaves are 12.89%, 3.84%, 8.76%, 11.30% and 8.10%, respectively. The total content of above five components accounts for 44.89% of the essential oil of the lavender leaves. Particularly, the borneol content in leaf essential oil is up to 12.89%. It is 125.2 times the amount of borneol in the flower essential oil. In conclusion, the suitable concentration of lanthanum can improve the adaptability of lavender plants, and heighten the content and quality of lavender essen

关键词： Lanthanum lavender Essential oil Secondary metabolites Osmotic stress Rare earths

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Effects of lavender and Citrus aurantium on pain of conscious intensive care unit patients: A parallel randomized placebo-controlled trial

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Journal of Integrative Medicine 2021年第4期19卷 333-339页

作者： Zahra Karimzadeh Mansooreh Azizzadeh Forouzi Haleh Tajadini Mehdi Ahmadinejad Callista Roy Mahlagha Dehghan Department of Critical Care Nursing Razi Faculty of Nursing and MidwiferyKerman University of Medical SciencesKerman ***Iran Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman ***Iran Department of Traditional Medicine Faculty of Traditional MedicineKerman University of Medical SciencesKerman ***Iran Department of Critical Care Medicine Kerman University of Medical SciencesKerman ***Iran Department of Nursing Mount Saint Mary's UniversityLos AngelesCA 90049USA Nursing Research Center Kerman University of Medical SciencesKerman ***Iran

Background: Conscious patients admitted to intensive care units(ICUs) suffer from pain for various reasons, which can affect their recovery ***: The present study compared the effects of aromatherapy with Citrus aurantium and lavender essential oils against placebo for reducing pain in conscious intensive care ***, setting, participants and interventions: This study was a parallel randomized placebo-controlled trial. The ICUs of two educational hospitals in Kerman in Southeastern Iran were the study *** hundred and fifty conscious intensive care patients were randomly divided into three groups using a stratified block randomization method. Two groups received aromatherapy with essential oils: one with lavender and the other with C. aurantium;these patients received a 30-minute therapy session using their assigned essential oil on the second day of their intensive care stay. The placebo group used 5 drops of normal saline instead of essential oil during their *** outcome measures: Patient’s pain was assessed using a visual analog scale before the aromatherapy intervention, as well as immediately after and one and three hours after ***: The mean pain score of the lavender group was 40.01 before the aromatherapy intervention and fell to 39.40, 30.60 and 23.68 immediately after the intervention, and at hour one and three postintervention, respectively. The mean pain score of the C. aurantium group was 45.48 before the intervention and was reduced to 32.34 at three hours after the intervention. The mean pain of the placebo group decreased from 42.80 before the intervention to 35.20 at three hours after the intervention. Pain scores of all groups decreased during the study(P lavender group was significantly lower than that of the placebo group at three hours after the ***: The results of this study showed that aromatherapy with lavender essential oil reduced pain

关键词： Pain lavender Citrus aurantium Intensive care Aromatherapy

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Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates:a randomized clinical trial

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World Journal of Pediatrics 2022年第6期18卷 398-403页

作者： Silvia Maya-Enero Montserrat Fàbregas-Mitjans Rosa Maria Llufriu-Marquès Júlia Candel-Pau Jordi Garcia-Garcia MaríaÁngeles López-Vílchez Department of Neonatology Service of PediatricsHospital del MarParc de Salut MarUniversitat Pompeu FabraPasseig Marítim 25-2908003BarcelonaSpain

Background Neonatal pain may affect long-term neurodevelopment and must be *** is a painful procedure wherein a common strategy to relieve pain(sucking)cannot be used because the technique is performed on the *** essential oil(LEO)has sedative and antispasmodic properties and has been successfully used to treat pain during heel puncture and *** aim was to demonstrate if the use of inhaled LEO is effective in reducing pain during frenotomy in healthy,full-term *** We conducted a randomized clinical trial in neonates who underwent a frenotomy between August 2020 and April *** assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and Neonatal Infant Pain Scale(NIPS)*** with type 3 tongue tie were randomized into the“experimental group”and“control group”.In both groups,we performed swaddling,administered oral sucrose,and let the newborn suck for two *** the experimental group,we also placed a gauze pad with one drop of LEO under the neonate’s nose for two minutes prior to and during the *** We enrolled 142 patients(71 per group).The experimental group showed significantly lower NIPS scores(1.88 vs 2.92)and cried almost half the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control group,we observed no side effects in either of the *** We observed a significant decrease in crying time and lower NIPS scores in the neonates who received inhaled LEO and underwent a frenotomy for type 3 ***,we recommend using inhaled LEO during neonatal frenotomies.

关键词： Ankyloglossia Aromatherapy Frenotomy lavender Neonate Neonatal pain Tongue-tie

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lavender aromatherapy on anxiety and depression in patients with Acute Coronary Syndrome: a single-blind randomized clinical trial

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Frontiers of Nursing 2022年第2期9卷 233-239页

作者： Mohammad Nategh Mohammad Reza Heidari Abbas Ebadi Reza Norouzadeh Zahra Mohebbinia Bahman Aghaie Department of Intensive Care Nursing Nursing and Midwifery FacultyShahed UniversityTehran ***Iran Department of Nursing Nursing and Midwifery FacultyShahed UniversityTehranTehran ***Iran Nursing Faculty Baqiyatallah University of Medical SciencesTehran ***Iran Department of Nursing Nursing and Midwifery FacultyShahed UniversityTehran ***Iran School of Nursing Shiraz University of Medical SciencesShiraz ***Iran Department of Medical-Surgical Nursing School of Nursing and MidwiferyQom University of Medical SciencesQom ***Iran

Objective:In cardiovascular disease,a patient’s anxiety and depression can increase cardiac rehabilitation duration and *** aromatherapy as a non-pharmacological intervention effective in other contexts may be an efficient intervention to alleviating anxiety and depression in patients with Acute Coronary Syndrome(ACS).Methods:In this study,110 ACS patients were randomly assigned to two intervention and control *** of the lavender fragrance was prescribed for the intervention group and the drop of aromatic almond for the control group for 3 ***:The first-day anxiety and depression were significantly different in the two groups at 1 h and 9 h after the ***’morning’s difference before the intervention was not significant,but it was substantial 1 h after the *** the third morning of the intervention,this difference was ***:This study confirmed the effectiveness of lavender aromatherapy in reducing anxiety and depression in ACS ***’study’s results enable intensive care nurses to use aromatherapy with lavender oil as a non-pharmacological and cost-effective intervention to reduce their psychological tensions and increase patient satisfaction during hospitalization in the cardiac care units(CCU).

关键词： anxiety aromatherapy Acute Coronary Syndrome depression lavender randomized clinical trial

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Determination of input-output energy and economic analysis of lavender production in Turkey

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International Journal of Agricultural and Biological Engineering 2016年第3期9卷 154-161页

作者： Osman Gökdoğan Department of Biosystems Engineering Faculty of Engineering-ArchitectureUniversity of Nevşehir HacıBektaşVeliNevşehir 50300Turkey

This research aims to perform an energy input-output analysis of lavender plant production in Isparta Province of *** order to determine the energy use efficiency of lavender plant,experiments and trials have been conducted on 10 lavender farms around Keçiborlu region of Isparta ***çiborlu region of Isparta Province is an important location for lavender *** these 10 lavender farms,energy input-output has also been calculated through trial and measurement methods during the production season of *** lavender production,energy input has been calculated as 6336.50 MJ/hm^(2)and energy output has been calculated as 17528.81 MJ/hm^(2).Energy inputs consist of chemical fertilizers energy by 52.88%,diesel energy by 33.32%,machinery energy by 9.72%,human labour energy by 2.85%and chemicals by 1.23%.Energy use efficiency,energy productivity,specific energy and net energy in lavender production have been calculated as 2.77;0.75 kg/MJ,1.34 MJ/kg and 11192.31 MJ/hm^(2),***-cost ratio has been calculated as 3.41 by dividing the gross value of production by the total cost of production per hectare.

关键词： output/input ratio energy specific energy lavender Turkey

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Using the Box-Behnken Response Surface Method to Optimize the Preparation and Characterization of lavender and Fennel Volatile oilβ-cyclodextrin Form Inclusion Complex

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World Journal of Traditional Chinese Medicine 2018年第2期4卷 54-61页

作者： Yuan-Yuan Liu Guo-Song Zhang Guang-Wei Zhu Ai-Ni-Wa-Er Aikemu Jia-Jia Ai Dong-Xun Li The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Traditional Chinese Medicine Chinese Medicine Research Institute Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Basic Medical College Xinjiang Medical University

Objective:The objective of this study is to study the best inclusion technology of lavender-and fennel-mixed volatile oil by beta?cyclodextrin(β-CD) and characterize the final product ***:Using the saturated water solution method,the volatile β-CD inclusion complex was *** effect of volatile oil weight ratio,inclusion temperature and inclusion time on the inclusive quality was studied by measuring the yield of inclusion and inclusion rate of volatile oil as evaluation *** preparation method of inclusion complex was then optimized by the Box-Behnken response surface *** inclusion complex was characterized by ultraviolet spectrophotometry,thin-layer chromatography,thermogravimetry and differential thermal analysis,and the microscopic imaging ***:The optimized conditions were the weight ratio of β-CD to volatile oil was 8.13:1(g/ml).The inclusion temperature was 44°*** inclusion time was 1 ***:We were able to produce an inclusion complex with high inclusion rate of volatile oil and high yield of inclusion using the preparation method mentioned ***,the method can also improve the stability of volatile oil in abnormal savda *** study can provide a good reference for the development of new preparations.

关键词： Fennel inclusion complex lavender response surface method volatile oil β-cyclodextrin

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Biochar Effect on Cadmium Accumulation and Phytoremediation Factors by lavender (<i>Lavandula stoechas</i>L.)

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Open Journal of Ecology 2017年第7期7卷 447-459页

作者： Seyyed Behrad Hashemi Mohammadreza Momayezi Daryoush Taleei Innovative Technologies in Functional Food Production Research Center Varamin-Pishva Branch Islamic Azad University Tehran Iran Medicinal Plants Research Center Shahed University Tehran Iran

The contaminated soil has become a global problem for agricultural and environmental scientists. The soil as a natural resource is polluted by cadmium as a heavy metals from the different sources such as phosphorus fertilizers. The aim of this study was to investigate the biochar effect on absorption factor (AF) and translocation factor (TF) as the phytoremediation factors at different cadmium concentrations by lavender plant. The experiment was conducted in 3 × 4 factorial design including biochar treatment at the volumetric percentage ratio of 0%, 20% and 40% v/v and cadmium treatment at 0, 50, 100 and 150 mg Cd⋅kg−1 soil under greenhouse condition. The data analysis indicated that the biochar and cadmium treatments significantly (p ≤0.05) affected the plant dry biomass. The biochar addition caused to decrease the cadmium content of the root tissue. Biochar decreased cadmium uptake by lavender plant and also cadmium was accumulated by the root tissue and was prevented to translocate cadmium into the shoot tissue. Increasing cadmium concentration in soil caused an increase in cadmium adsorption factor however there was a significant decrease for translocation factor. It can be concluded to consider the possibility of planting the lavender with biochar application to amend the cadmium contaminated soils.

关键词： Biochar Cadmium Contaminated Soil Phytoremediation lavender Translocation Factor Absorption Factor

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Quantitative Analysis of lavender (<i>Lavandula angustifolia</i>) Essential Oil Using Multiblock Data from Infrared Spectroscopy

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American Journal of Analytical Chemistry 2014年第10期5卷 633-645页

作者： Nathalie Dupuy Vincent Gaydou Jacky Kister Aix Marseille University LISA METICA EA4672 F-13397 Marseille 20 France

Near-infrared and mid-infrared spectroscopies were currently used to analyze natural compounds. During the last ten years various multiblocks methods were developed such as Concatenated PLS, Hierarchical-PLS (H-PLS), and MultiBlock-PLS (MB-PLS). These three algorithms were used to analyze 55 lavender (Lavandula angustifolia) essential oil samples. The results obtained were compared to the ones obtained respectively in NIR and MIR ranges. The accuracies of the models depend on the spectroscopic technique, pretreatment and the PLS methods. The results showed that the choice of the factor numbers used to build the multiblock models was the most important parameter for the H-PLS and MB-PLS methods.

关键词： Multiblock Regression Lavandula angustifolia lavender Essential Oil NIR MIR H-PLS MB-PLS

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