Using the Box-Behnken Response Surface Method to Optimize the Preparation and Characterization of Lavender and Fennel Volatile oilβ-cyclodextrin Form Inclusion Complex

作     者：Yuan-Yuan Liu Guo-Song Zhang Guang-Wei Zhu Ai-Ni-Wa-Er Aikemu Jia-Jia Ai Dong-Xun Li 

作者机构：The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal MedicineJiangxi University of Traditional Chinese Medicine Chinese Medicine Research InstituteInstitute of Chinese Materia Medica China Academy of Chinese Medical Sciences Basic Medical CollegeXinjiang Medical University 

出 版 物：《World Journal of Traditional Chinese Medicine》 (世界中医药杂志（英文）)

年 卷 期：2018年第4卷第2期

页      面：54-61页

学科分类：1008[医学-中药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(no:81660667) 

主　　题：Fennel inclusion complex lavender response surface method volatile oil β-cyclodextrin 

摘      要：Objective:The objective of this study is to study the best inclusion technology of Lavender-and fennel-mixed volatile oil by beta?cyclodextrin(β-CD) and characterize the final product ***:Using the saturated water solution method,the volatile β-CD inclusion complex was *** effect of volatile oil weight ratio,inclusion temperature and inclusion time on the inclusive quality was studied by measuring the yield of inclusion and inclusion rate of volatile oil as evaluation *** preparation method of inclusion complex was then optimized by the Box-Behnken response surface *** inclusion complex was characterized by ultraviolet spectrophotometry,thin-layer chromatography,thermogravimetry and differential thermal analysis,and the microscopic imaging ***:The optimized conditions were the weight ratio of β-CD to volatile oil was 8.13:1(g/ml).The inclusion temperature was 44°*** inclusion time was 1 ***:We were able to produce an inclusion complex with high inclusion rate of volatile oil and high yield of inclusion using the preparation method mentioned ***,the method can also improve the stability of volatile oil in abnormal savda *** study can provide a good reference for the development of new preparations.