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How do lateral septum projections to the ventral CA1 influence sociability?

Neural Regeneration Research 2024年第8期19卷 1789-1801页

作者： Dan Wang Di Zhao Wentao Wang Fengai Hu Minghu Cui Jing Liu Fantao Meng Cuilan Liu Changyun Qiu Dunjiang Liu Zhicheng Xu Yameng Wang Yu Zhang Wei Li Chen Li Department of Rehabilitation Medicine Binzhou Medical University HospitalBinzhouShandong ProvinceChina Medical Research Center Binzhou Medical University HospitalBinzhouShandong ProvinceChina Institute for Metabolic&Neuropsychiatric Disorders Binzhou Medical University HospitalBinzhouShandong ProvinceChina Department of Psychology Binzhou Medical University HospitalBinzhouShandong ProvinceChina College of Nursing Binzhou Medical UniversityBinzhouShandong ProvinceChina

Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.

关键词： chemogenetics GABA receptor GABAergic neurons glutamatergic neurons lateral septum neural excitability neural projection social novelty social preference ventral CA1

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lateral septum GABAergic neurons regulate active-period sleep and stress-induced insomnia

Lateral septum GABAergic neurons regulate active-period slee...

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中国睡眠研究会第十届全国学术年会

作者： Tian-Xiao Wang Jian-Ni Hui-Dong Wei-Min Qu Zhi-Li Huang Department of Pharmacology School of Basic Medical SciencesFudan University

Sleep architecture is often disturbed following a stressful event;nevertheless,the brain circuitry responsible for sleep perturbations by stress has been paid little attention.The lateral septum（LS） has been shown to have a key role in stress responses and involved in the regulation of cortical activity.However,the exact role of the LS on sleep modulation is not clear.In this study,neuronal activity in LS GABAergic neurons of freely behaving mice was recorded by fiber photometry technology,and chemogenetic and cell-selective lesion approaches were used to identify the essential role of the LS in regulating the sleep-wake behavior.Results showed that LS GABAergic neurons increased their population activity at arousal state.Then,chemogenetic activation of LS GABAergic neurons expressing hM3 Dq receptors significantly increased the non-rapid eye movement（NREM） sleep during the active period,whereas chemogenetic inhibition of LS GABAergic neurons led to a significant decrease of NREM sleep at inactive period,but not active period of mice.Moreover,selectivity lesions of LS GABAergic neurons significantly increased wakefulness during the active period and aggravated insomnia caused by a psychological stressor（cage exchange） at inactive period.Finally,dysfunction of the lateral septal nucleus significantly increased c-fos expression in the basal forebrain and lateral hypothalamus during the cage exchange.Conclusively,these findings indicate that the LS GABAergic neurons reveal a prominent contribution to regulate the active-period sleep and stress-induced insomnia.

关键词： Chemogenetics Insomnia lateral septum Sleep

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