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Journal of Innovative Optical Health Sciences 2024年第1期17卷 69-75页

作者： Xiang Huang Dacheng Tang Pan Chen Lumiao Chen Xiaohong Li Xiaoping Wang Department of Pain Management The First A±liated Hospital Jinan University Guang ZhouGuangdong 510630P.R.China Department of Pain Management The First People's Hospital of Foshan Foshan City Guangdong 528000P.R.China

Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on *** speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of *** assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational *** analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS *** results showed that the VAS scores of all patients decreased ***,the bloodflow index(BFI)values were signi-cantly higher than they were before the *** bloodflow and pain alleviation were positively ***-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by *** alleviation by tSCS was positively correlated with increased bloodflow in the *** effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.

关键词： laser speckle contrast imaging temporary spinal cord stimulation postherpetic neuralgia

laser speckle contrast imaging compared with indocyanine green in renal perfusion of a porcine model

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Current Urology 2023年第2期17卷 141-145页

作者： Jonathan Noël Anya Mascarenhas Chibueze A.Nwaiwu Yao Liu Marcio Moschovas Vasiliy E.Buharin John Oberlin Saloni Mehrotra Alyson F.Dechert Peter C.W.Kim Vipul Patel Department of Urology AdventHealth Global Robotics InstituteCelebrationFL 34747USA Harvard University CambridgeMAUSA Department of Surgery Warren Alpert Medical School of Brown UniversityRhode Island HospitalProvidenceRIUSA Department of Research Activ Surgical Inc.BostonMAUSA Department of Surgery University of BuffaloBuffaloNYUSA

Background:When viewed under near-infrared light,indocyanine green(ICG)signal for kidney perfusion can be utilized in partial *** speckle contrast imaging(LSCI)uses coherent light to detect perfusion during real-time laparoscopic *** and methods:laser speckle contrast imaging or ActivSight,an imaging sensor adapter,was used during laparoscopy of an anesthetized porcine kidney ***'s"perfusion mode"and"quantification mode"displayed the blood flow as a heatmap and numerical signal intensity,***:After the upper segmental renal artery was clamped,ICG was seen in the lower pole,and LSCI showed low unit(dark color)quantification and perfusion in the upper *** green was retained in the lower pole after the upper segmental artery was unclamped,and LSCI perfusion was demonstrated in the entire ***:laser speckle contrast imaging is a dye-free,repeatable,real-time adjunct for renal parenchymal perfusion assessment applicable to minimally invasive renal surgery to complement the technology of ICG near-infrared fluorescence and advance digital surgery.

关键词： Augmented reality Indocyanine green laser speckle contrast imaging Perfusion Selective arterial clamping

IN VIVO MAPPING BRAIN MICROCIRCULATION BY laser speckle contrast imaging:A MAGNETIC RESONANCE PERSPECTIVE OF THEORETICAL FRAMEWORK

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 239-256页

作者： ZHENG WANG Center for Functional and Metabolic Mapping Robarts Research Institute Department of Medical Biophysics The University of Western Ontario LondonCanada

The fundamental limitations of most vascular-based functional neuroimaging techniques are placed by the fact how fine the brain regulates the blood supply *** vivo mapping of the cerebral microcirculation with high resolution and sensitivity hence becomes unprecedentedly *** paper reviews the theoretical background of the laser speckle contrast imaging(LSCI)technique and attempts to present a complete framework stemming from a simple biophysical *** the sensitivity analysis,more insights into the tool optimization are attained for in vivo *** questions of the technical aspects are discussed within this unified ***,it concludes with a brief perspective of future research in a way analogous to the magnetic resonance imaging(MRI)*** exploration could catalyze their development and initiate a technological fusion for precise assessment of blood flow across various spatial scales.

关键词： laser speckle contrast imaging brain microcirculation functional neuroimaging magnetic resonance imaging

A New Method for Evaluating Regional Cerebral Blood Flow Changes:laser speckle contrast imaging in a C57BL/6J Mouse Model of Photothrombotic Ischemia

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第2期36卷 174-180页

作者：邱占东邓刚杨佳闵喆李大勇方瑜张苏明 Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Neurology Beijing Friendship HospitalCapital Medical University Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

The present study aimed to improve the processing of data acquired from laser speckle contrast imaging（LSCI） to provide a standardization method to explore changes in regional cerebral blood flow（r CBF） and to determine the correlations among r CBF, cerebral ischemic lesion volume and microvascular density over time in a focal ischemic region. C57BL/6J mice were subjected to focal photothrombotic（PT） ischemia. r CBF was measured using LSCI at different time points before and after PT ischemia through an intact skull. Standardized r CBF（Sr CBF）, defined as the ratio of r CBF measured in the ipsilateral region of interest（ROI） to that in the corresponding contralateral region, was calculated to evaluate potential changes. In addition, the volume of the ischemic lesion and the microvascular density were determined using Nissl staining and immunofluorescence, respectively. The relationships among the ischemic lesion volume, microvascular density and Sr CBF were analyzed over time. The results showed that the cortical r CBF measured using LSCI following PT ischemia in the C57BL/6J mice gradually increased. Changes in the cerebral ischemic lesion volume were negatively correlated with Sr CBF in the ischemic region. Changes in the microvascular density were similar to those observed in Sr CBF. Our findings indicate that LSCI is a practical technique for observing changes in murine cortical r CBF without skull opening and for analyzing the relationships among the ischemic lesion volume, microvascular density and Sr CBF following focal cerebral ischemia. Preliminary results also suggest that the use of LSCI to observe the formation of collateral circulation is feasible.

关键词： cerebral blood flow collateral circulation laser speckle contrast imaging photothrombotic ischemia

Hidden stage of intracranial hemorrhage in newborn rats studied with laser speckle contrast imaging and wavelets

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 99-106页

作者： Alexey N.Pavlov Arkady S.Abdurashitov Olga N.Pavlova Valery V.Tuchin Olga S.Sindeeva Sergey S.Sindeev Oxana V.Semyachkina-Glushkovskaya Department of Physics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Department of Biology Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia

Using the laser speckle contrast imaging and wavelet-based analyses,we investigate a latent("hidden")stage of the development of intracranial hemorrhages(ICHs)in newborn *** apply two measures based on the continuous wavelet-transform of blood flow velocity in the sagittal sinus,namely,the spectral energy in distinct frequency ranges and a multiscality degree characterizing complexity of experimental *** show that the wavelet-based multifractal formalism reveals changes in the cerebrovascular blood flow at the development of ICH.

关键词： Cerebral blood flow laser speckle contrast imaging stress wavelet-analysis complexity

ASSESSMENT OF OPTICAL CLEARING INDUCED IMPROVEMENT OF laser speckle contrast imaging

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 159-167页

作者： JING WANG DAN ZHU MIN CHEN XIAOJING LIU Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074China Affiliated Hospital Huazhong University of Science and Technology Wuhan 430074China

laser speckle contrast imaging(LSCI)plays an important role in studying blood flow,but suffers from limited penetration depth of light in turbid *** strong scattering of tissue obviously reduces the image contrast which decreases the sensitivity to flow *** image processing or optical clearing methods have been proposed to lessen the deficiency,but quantitative assessment of improvement is seldom *** this study,LSCI was applied to monitor the blood flow through a capillary embedded within various tissue phantoms at depths of 0.25,0.45,0.65,0.85 and 1.05 mm,and the flow velocity in capillary was controllable from 0 to 4mm/***,glycerol,a common optical clearing agent,was mixed with Intralipid at different volume ratio to make the reduced scattering coefficient of tissue phantom decrease from 13.00 to 0.50 cm−*** quantitative analysis demonstrates that the optical clearing method can obviously enhance the image contrast,imaging depth,and sensitivity to blood flow *** the laser speckle contrast Analysis methods and the optical clearing method,we find that for typical turbid tissue,the sensitivity to velocity estimated by the laser speckle Temporal contrast Analysis(LSTCA)is twice of that by the laser speckle Spatial contrast Analysis(LSSCA);while the sensitivity to velocity estimated by using the two analysis methods has a 10-fold increase,respectively,if addition of glycerol makes the reduced scattering coefficient of tissue phantom decrease by 30%.Combining the LSTCA and the optical clearing method,the sensitivity to flow velocity will be further enhanced.

关键词： Glycerol laser speckle contrast imaging the sensitivity to flow velocity estimation optical clearing scattering tissue phantom

激光散斑成像技术观察浮针治疗急性贝尔面瘫案:病例报道

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World Journal of Acupuncture-Moxibustion 2024年第1期34卷 67-71页

作者：方文佳孙健杨小林易玮广州中医药大学针灸康复临床医学院广州510405 广东省中医院芳村分院传统疗法科广州510370

One case of acute Bell’s palsy was reported and treated with Fu’s subcutaneous needling(FSN).Present symptoms:facial muscle stiffness on the right side,ptosis of labial angle,failure to frown the right eyebrow,the eyeball exposed about 2 mm when gently closing the eyes,air leaking when bulging the cheeks,drooling when brushing the teeth and gargling,and food retained in the cheek when *** medicine diagnosis:peripheral facial *** Chinese medicine diagnosis:facial *** subcutaneous swaying movement and reperfusion action of FSN were adopted on the affected muscles and achieved the remarkably effects on incomplete closure of eyes and drooping of the *** patient was recovered *** and after treatment,the laser speckle contrast imaging was used to observe the improvement of blood flow on the face,which provides the idea for the research and clinical practice of Fu’s subcutaneous needling in treatment of Bell’s palsy.

关键词： Fu’s subcutaneous needling Bell’s palsy laser speckle contrast imaging

Characterization of cerebral blood flow dynamics with multiscale entropy

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 85-93页

作者： Alexey N.Pavlov Arkady S.Abdurashitov Olga N.Pavlova Maria V.Ulanova Anastasia A.Bodrova Natalia A.Shushunova Alexander P.Khorovodov Oxana V.Semyachkina-Glushkovskaya Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Street Saratov 410054Russia Saratov National Research State University 83 Astrakhanskaya Street Saratov 410012Russia

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral *** discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group *** also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound *** show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

关键词： Cerebral blood flow laser speckle contrast imaging arterial pressure complexity

In vivo monitoring of microneedle-based transdermal drug delivery of insulin

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 84-95页

作者： Jiawei Zhao Yongbo Wu Junbo Chen Bangrong Lu Honglian Xiong Zhilie Tang Yanhong Ji School of Physics and Telecom Engineering South China Normal University No.378 West Waihuan Street Guangzhou 510006P.R.China MOE Key Laboratory of laser Life Science and Institute of laser Life Science College of Biophotonics South China Normal University No.55 Zhongshan Xi RoadGuangzhou 510631P.R.China

Soluble microneedles(MNs)have recently become an eficient and minimally invasive tool in transdermal drug delivery because of their excellent biocompatibility and rapid ***,direct monitoring of structural and functional changes of MNs in vivo to estimate the efficieancy of insulin delivery is *** monitored the dissolution of MNs to obtain structural imaging of MNs'changes by using optical coherence tomography(OCT).We also observed the effect of MNs on microvascular conditions with laser speckle contrast imaging(LSCIT)and measured the blood perfusion of skin to obtain functional imaging of *** determined the performance of two soluble MN arrays made from polyvinyi alcohol(PVA)and polyvinyl alco-hol/polyvinylpyrolidone(PVA/PVP)by calculating the cross sectional areas of the micro-channels in mouse skin as a function of ***,the change in blood glucose before and after using MNs loaded with insulin was evaluated as an auxiliary means to demonstrate the ability of the soluble MNs to deliver *** showed that the structural imaging of these MNs could be observed in vivo via OCT in real time and the fumctional imaging of MNs could be showed using LSCI OCT and LSCI are potential tools in monitoring MNs structural and functional changes.

关键词： Soluble microneedle insulin optical coherence tomography laser speckle contrast imaging

Mesenteric traction syndrome in pigs:A single-blinded,randomized controlled trial

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Animal Models and Experimental Medicine 2021年第2期4卷 162-168页

作者： Rune B.Strandby Jens T.F.Osterkamp Rikard Ambrus Amelie Henriksen Jens P.Goetze Niels H.Secher Michael P.Achiam Lars-Bo Svendsen Department of Surgical Gastroenterology RigshospitaletUniversity of CopenhagenCopenhagenØDenmark Department of Clinical Biochemistry RigshospitaletUniversity of CopenhagenCopenhagenØDenmark Department of Anaesthesia RigshospitaletUniversity of CopenhagenCopenhagenØDenmark

Background:Mesenteric traction syndrome is commonly observed in patients undergoing upper abdominal surgery and is associated with severe postoperative complications.A triad of hypotension,tachycardia,and facial flushing seems provoked by prostacyclin(PGI 2)release from the gut in response to mesenteric *** administration of nonsteroidal anti-inflammatory drugs(NSAID)inhibits PGI 2 release,stabilizing the hemodynamic ***,we examined the effect of mesenteric traction on splanchnic blood flow in pigs randomized to NSAID or placebo *** and Methods:Twenty pigs were allocated to either ketorolac or pla-cebo *** minutes of manual mesenteric traction was *** 6-keto-PGF1,a stable metabolite of PGI 2,hemodynamic variables,and regional blood flow(laser speckle contrast imaging)to the liver,stomach,small intestine,upper lip,and snout(laser Doppler flowmetry)were recorded prior to traction and 5 and 30 minutes ***:Both groups of pigs presented a decrease in systemic vascular resistance(P.01),mean arterial blood pressure(P.001),and blood flow in the gastric an-trum(P.002).Plasma 6-keto-PGF1 did not increase in either group(P.195),and cardiac output,heart rate,central venous pressure,and blood flow to the liver,small intestine,upper lip,and snout remained ***:Mesenteric traction resulted in cardiovascular depression,including re-duced blood flow in the gastric *** 6-keto-PGF1 did not increase,and ketorolac administration did not alter the response to mesenteric *** studies are needed to identify which substance is responsible for eliciting the cardio-vascular response to mesenteric traction in pigs.

关键词： 6-keto-PGF1 gastric blood flow hemodynamics laser speckle contrast imaging mesenteric traction syndrome prostacyclin