In vivo monitoring of microneedle-based transdermal drug delivery of insulin

作     者：Jiawei Zhao Yongbo Wu Junbo Chen Bangrong Lu Honglian Xiong Zhilie Tang Yanhong Ji 

作者机构：School of Physics and Telecom Engineering South China Normal UniversityNo.378 West Waihuan Street Guangzhou 510006P.R.China MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science College of BiophotonicsSouth China Normal University No.55 Zhongshan Xi RoadGuangzhou 510631P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2018年第11卷第5期

页      面：84-95页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(Nos.81571837 81601534 and 61575067) 

主　　题：Soluble microneedle insulin optical coherence tomography laser speckle contrast imaging 

摘      要：Soluble microneedles(MNs)have recently become an eficient and minimally invasive tool in transdermal drug delivery because of their excellent biocompatibility and rapid ***,direct monitoring of structural and functional changes of MNs in vivo to estimate the efficieancy of insulin delivery is *** monitored the dissolution of MNs to obtain structural imaging of MNs changes by using optical coherence tomography(OCT).We also observed the effect of MNs on microvascular conditions with laser speckle contrast imaging(LSCIT)and measured the blood perfusion of skin to obtain functional imaging of *** determined the performance of two soluble MN arrays made from polyvinyi alcohol(PVA)and polyvinyl alco-hol/polyvinylpyrolidone(PVA/PVP)by calculating the cross sectional areas of the micro-channels in mouse skin as a function of ***,the change in blood glucose before and after using MNs loaded with insulin was evaluated as an auxiliary means to demonstrate the ability of the soluble MNs to deliver *** showed that the structural imaging of these MNs could be observed in vivo via OCT in real time and the fumctional imaging of MNs could be showed using LSCI OCT and LSCI are potential tools in monitoring MNs structural and functional changes.