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AN INVESTIGATION INTO HYPERTENSION DUE TO RENAL TUBERCULOSIS

中华医学杂志(英文版) 1965年第5期84卷 327-331页

作者：熊汝成缪廷杰陈长春章仁安缪中良赵淑英 Department of Surgery Chung Shan HospitalShanghai First Medical CollegeShanghai

A critical analysis of 761 cases ofrenal tuberculosis aged under 45 yearswas presented,among which 45 *** 30 cases treated bynephrectomy,26 were followed up for2 *** were 23 cases withnormal blood pressure after *** main pathologic changes inrenal tuberculosis with hypertensionwere *** is believed that themethod of juxtaglomerular cell countsis of clinieopathologic *** mechanism of hypertension inrenal tuberculosis,the therapeutic valueof nephrectomy and the postoperativerecurrence of hypertension werediscussed.

关键词： HISTOLOGY HYPERTENSION, RENAL HYPERTROPHY kidney glomerulus NEPHRECTOMY PATHOLOGY TUBERCULOSIS, RENAL

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Genetic variation of mannose-binding protein associated with glomerular immune deposition in IgA nephropathy

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Chinese Medical Journal 2002年第2期115卷 192-196,148页

作者：龚如军刘志红陈朝红黎磊石南京大学医学院临床学院南京军区南京总医院解放军肾脏病研究所南京210002

OBJECTIVE: To investigate the relationship between codon 54 gene polymorphism of the host defense molecule, mannose-binding protein (MBP), and the patterns of glomerular immune deposition in IgA nephropathy (IgAN). METHODS: IgAN patients with different patterns of glomerular immune deposition were selected and divided into two groups. Group A consisted of 77 patients with glomerular IgA and C3 deposits, and Group AGM consisted of 70 patients with glomerular IgA, IgG, IgM, C3 and Clq deposits. Clinical features and laboratory relevant data of all patients were collected. One-hundred and forty healthy adults were recruited as normal controls. The MBP gene codon 54 GGC/GAC polymorphism was investigated by using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The genotype frequency of GGC/GAC heterozygotes was significantly higher in Group AGM as compared with that of Group A (41.4% vs 19.5%, P

关键词： Adult Alleles Carrier Proteins Collectins DNA Female Gene Frequency Genotype Glomerulonephritis, IGA Humans kidney glomerulus Male Polymorphism, Restriction Fragment Length Research Support, Non-U.S. Gov't Variation (Genetics)

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Epidemiology of biopsy-proven glomerular diseases in Chinese children: A scoping review

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Chronic Diseases and Translational Medicine 2022年第4期8卷 271-280页

作者： Yetong Li Yue Yang Li Zhuo Dan Wu Wenge Li Xiaorong Liu Department of Nephrology Beijing Children's HospitalNational Centerfor Children's HealthCapital Medical UniversityBeijingChina Department.of Nephrology China-Japan Friendship HospitalCapital Medical UniversityBeijingChina

Background: Glomerular disease is the leading cause of chronic kidney disease globally. No scoping review reports have focused on China’’s spectrum of glomerular diseases in children. This study aimed to systematically identify and describe retrospective studies on pediatric glomerular disease based on available data on sex, age, study period, and ***: Six databases were systematically searched for relevant studies from initiation to December 2021 in PubMed, Embase, Web of Science, Global Health Library, Wangfang Database, and ***: Thirty-four studies were identified in the scoping review, including 40,430 patients with biopsy-proven diagnoses. The proportion of boys was significantly higher than that of girls. In this study, 28,280 (70%) cases were primary glomerular disease, 10,547 (26.1%) cases were diagnosed as secondary glomerular disease, and 1146 (2.8%) cases were hereditary glomerular disease. Minimal change disease is the most common glomerular disease among children in China, followed by mesangial proliferative glomerulonephritis, IgA nephropathy, and purpura nephritis. We observed increments in glomerular diseases in periods 2 (2001–2010) and 3 (2011–2021). The proportion of major glomerular diseases varies significantly in the different regions of ***: The spectrum of pediatric glomerular diseases varied across sex, age groups, study periods, and regions, and has changed considerably over the past 30 years.

关键词： child and adolescent China glomerular disease kidney glomerulus renal biopsy

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Effect of probucol on mRNA expression of glomerular antioxidant enzymes in rat with subtotal nephrectomy

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中华医学杂志(英文版) 1996年第10期109卷 786-786页

作者： Tang Zheng Ji Daxu Li Leishi Mitsumi Fukui Yasuhiko Tomino Hikaru Koide 210002 Department of Nephrology School of Medicine Juntendo University Tokyo Japan

OBJECTIVE To investigate 1) the glomerular mRNA expression and protein activity of antioxidant enzymes (AOEs) including superoxide dismutase (SOD) and glutathine peroxidase (GSH-Px) and the glomerular content of lipid peroxide-malondiadehyde (MDA), 2) the effects of probucol (P), a potent antioxidant agent on these AOEs and MDA levels, in the chronic phase of subtotal nephrectomized *** The adult male Spregue-Dawley rats were randomly divided into three groups at the first week after subtotal renal ablation. Group 1 was sham rats (sham n=8), group 2 underwent 5/6 nephrectomy without special therapy (5/6 Nx n=8), and group 3 with 5/6 nephrectomy received probucol (5/6 Nxs+P n=8) at a dose of 1% in the rat chow. At the 12th week after P was administrated, all of the rats were sacrificed to remove left kidney for the determination of glomerular level of MDA, activity of SOD, and GSH-Px, glomerular mRNA expression of AOEs by Northern blot analysis as well as a histological *** In 5/6 Nx, serum cholesterol, proteinuria increased and creatinine clearance decreased progressively with age as compared with that in sham. Those abnormalities as well as glomerulosclerosis index (GI) ameliorated with the administration of probucol at the 12th week after subtotal nephrectomy [GI: sham 3.12±1.20, Pkidney, which may contribute to the progression of renal injury. The protective effects of probucol on both renal functional impairment and the development of glomerulosclerosis may be partially associated with improving surviving glomerular AOEs.

关键词： protein structure function Rats mRNA Expression Probucol Nephrectomy Glomerulosclerosis kidney glomerulus Placebos Left kidney

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