Genetic variation of mannose-binding protein associated with glomerular immune deposition in IgA nephropathy

作     者：龚如军 刘志红 陈朝红 黎磊石 GONG Rujun;LIU Zhihong;CHEN Zhaohong;LI Leishi

作者机构：南京大学医学院临床学院南京军区南京总医院解放军肾脏病研究所南京210002 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2002年第115卷第2期

页      面：192-196,148页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：theJiangsuProvincialScienceandTechnologyFoundationforYouth (No .BQ96 0 32 ) 

主　　题：Adult Alleles Carrier Proteins Collectins DNA Female Gene Frequency Genotype Glomerulonephritis, IGA Humans Kidney Glomerulus Male Polymorphism, Restriction Fragment Length Research Support, Non-U.S. Gov't Variation (Genetics) 

摘      要：OBJECTIVE: To investigate the relationship between codon 54 gene polymorphism of the host defense molecule, mannose-binding protein (MBP), and the patterns of glomerular immune deposition in IgA nephropathy (IgAN). METHODS: IgAN patients with different patterns of glomerular immune deposition were selected and divided into two groups. Group A consisted of 77 patients with glomerular IgA and C3 deposits, and Group AGM consisted of 70 patients with glomerular IgA, IgG, IgM, C3 and Clq deposits. Clinical features and laboratory relevant data of all patients were collected. One-hundred and forty healthy adults were recruited as normal controls. The MBP gene codon 54 GGC/GAC polymorphism was investigated by using polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The genotype frequency of GGC/GAC heterozygotes was significantly higher in Group AGM as compared with that of Group A (41.4% vs 19.5%, P