检索结果-南通市图书馆

Quantum-confined superfluid: From nature to artificial

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2018年第8期61卷 1027-1032页

作者： Liping Wen Xiqi Zhang Ye Tian Lei Jiang Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Biological ion channels show that ultrafast ions and molecules transmission are in a quantum way of single molecular or ionic chain with a certain number of molecules or ions, and we define it as ＂quantum-confined superfluid＂（QSF）. This ordered ultrafast flow in the confined channel can be considered as ＂quantum tunneling fluid effect＂ with a ＂tunneling distance＂, which is corresponding to the period of QSF. Recent research demonstrated that artificial biomimetic nanochannels also showed the phenomenon of QSF, such as ion and water channels. The introduction of QSF concept in the fields of chemistry and biology may create significant impact. As for chemistry, the QSF effect provides new ideas for accurate synthesis in organic, inorganic, polymer, etc. We believe the implementation of the idea of QSF will promote the development of QSF biochemistry, biophysics, bioinformatics and biomedical science.

关键词： quantum-confined superfluid quantum tunneling fluid effect ion channels artificial nauochannels

Application of Biological Nanopore Sequencing Technology in the Detection of Microorganisms

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第23期41卷 3473-3483页

作者： Ming-Qian Zhang Xiao-Bin Huang Hai-Chen Wu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

Environmental pollution and the spread of pathogenic microorganisms pose a significant threat to the health of humans and the ***,understanding and detecting microorganisms is crucial for maintaining a healthy living *** sequencing is a single-molecule detection method developed in the 1990s that has revolutionized various research *** offers several advantages over traditional sequencing methods,including low cost,label-free,time-saving detection speed,long sequencing reading,real-time monitoring,convenient carrying,and other significant *** this review,we summarize the technical principles and characteristics of nanopore sequencing and discuss its applications in amplicon sequencing,metagenome sequencing,and whole-genome sequencing of environmental microorganisms,as well as its in situ application under some special *** also analyze the advantages and challenges of nanopore sequencing in microbiology ***,nanopore sequencing has the potential to greatly enhance the detection and understanding of microorganisms in environmental research,but further developments are needed to overcome the current challenges.

关键词： Nanopore sequencing technology Environmental microorganisms Amplicon sequencing Metagenome sequencing Whole genome sequencing Gene technology ion channels Nucleic acids

Oxygen and nitrogen tailoring carbon fiber aerogel with platinum electrocatalysis interfaced lithium/sulfur(Li/S)batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第1期34卷 145-151页

作者： Lei Ji Xia Wang Yongfeng Jia Xiaoxi Qin Yi Sui Huizhong Yan Zhiqiang Niu Jinghai Liu Yuegang Zhang State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Inner Mongolia Key Laboratory of Carbon Nanomaterials Nano Innovation Institute(NII)College of Chemistry and Materials ScienceInner Mongolia MinZu UniversityTongliao 028000China Department of Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China

Sluggish kinetics of lithium/sulfur(Li/S)conversion chemistry and the ion channels formation in the cathode is still a bottleneck for developing future Li/S batteries with high-rate,long-cycling and ***,a rational cathode structure design of an oxygen(O)and nitrogen(N)tailoring carbon fiber aerogel(OCNF)as a host material integrated with platinum(Pt)electrocatalysis interface is employed to regulate Li/S conversion chemistry and ion *** Pt nanoparticles were uniformly sprayed onto the S surface to construct the electrocatalysis interface(Pt/S/OCNF)for generating ion channels to promote the effective penetration of electrolyte into the *** Pt/S/OCNF gives the cathode a high sulfur utilization of 77.5%,an excellent rate capacity of 813.2 m Ah/g(2 C),and an outstanding long-cycling performance with a capacitance retention of 82.6%and a decay of 0.086%per cycle after 200 cycles at 0.5 *** functional theory(DFT)calculations reveal that the Pt electrocatalysis interface makes the cathode a high density of state(DOS)at Fermi level to facilitate the electrical conductivity,charge transfer kinetics and electrocatalysis to accelerate the lithium polysulfides(LiPSs)electrochemical ***,the unique chemisorption structure and adsorption ability of Li2Sn(n=1,2,4,6,8)and S8on OCNF are attributed to the bridging effects of interfacial Pt and the bonding of *** Pt electrocatalysis interface combined with the unique 3D hierarchical porous structure and abundant functional active sites at OCNF guarantee strong adsorption confinement,fast Li/S electrocatalytic conversion and unblocked ion channels for electrolyte permeation in cathode.

关键词： Li/S conversion chemistry ion channels Pt electrocatalysis interface 3D aerogel host(OCNF) Adsorption confinement

MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1617-1622页

作者： Xin-Yi Gu Bo Jin Zhi-Dan Qi Xiao-Feng Yin Department of Orthopedics and Traumatology Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) BeijingChina Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu ProvinceChina

MicroRNAs can regulate the function of ion channels in many *** on our previous study we propose that miR-142a-39,which is highly expressed in denervated skeletal muscle,might affect cell excitability through similar *** this study,we overexpressed or knocked down miR-142a-3p in C2C12 cells using a lentivirus *** 7 days of differentiation culture,whole-cell currents were *** results showed that overexpression of miR-142a-3p reduced the cell membrane capacitance,increased potassium current density and decreased calcium current *** of miR-142a-3p reduced sodium ion channel current *** results showed that change in miR-142a-3p expression affected the ion channel currents in C2C12 cells,suggesting its possible roles in muscle cell *** study was approved by the Animal Ethics Committee of Peking University in July 2020(approval ***2017128).

关键词： C2C12 denervation ion channels microRNA miR-142a-3p muscle patch clamp potassium sodium whole-cell currents

Bufalin-induced cardiotoxicity: new findings into mechanisms

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第7期18卷 550-560页

作者： LI Min WANG Xi-Jie ZHAO Qi WANG Jia-Xian XING Hong-Yan ZHANG Yi-Zhe ZHANG Xue-Xia ZHI Yang-Yang LI Hua MA Jing China State Institutes of Pharmaceutical Industry National Shanghai Center for New Drug Safety Evaluation and Research Shanghai 201203China Shanghai InnoStar Bio-Tech Co. Ltd.Shanghai 201203China Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 211100China Department of Research and Development HELP Stem Cell TherapeuticsNanjing 211100China

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine *** cardiotoxicity clearly limits its application to patients living in ***,an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse *** investigate the cardiotoxicity of bufalin using human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.003–0.1μmol·L–1),human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.03–0.3μmol·L–1)and eight human cardiac ion channel currents(0.01–100μmol·L–1)combined with an impedance-based bioanalytical and patch clamp *** effect of bufalin on the contractility in hiPSC-CMs,which has been shown to strengthen myocardial contractility,accelerate conduction,and increase beating rate at the earlier stage of administration,whereas weakened myocardial contractility,abolished conduction,and ceased beating rate at the later stage of *** decreased the action potential duration(Action potential duration at 30%,50%and 90%repolarization),cardiac action potential amplitude,and maximal depolarization rate and depolarized the resting membrane potential of *** beating rates of hiPSC-CMs were markedly increased at 0.03μmol·L–1,while were weakened at 0.3μmol·L–1 after *** blocks INav1.5 in a concentration-dependent manner with half maximal inhibitory concentration of 74.5μmol·L–*** respectively increased the late sodium current and Na+-Ca2+exchange current with a concentration for 50%of maximal effect of 2.48 and 66.06μmol·L–1 in ***,bufalin showed no significant effects on other cardiac ion channel *** enhancement of the late sodium current is one of the main mechanism for cardiotoxicity of bufalin.

关键词： Bufalin Cardiomyocytes Cardiotoxicity ion channels Stem cell

Recent Advances in Nanopore Sensing

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第7期39卷 2035-2043页

作者： Mengjie Cui Yaxian Ge Xiao Zhuge Xin Zhou Dongmei Xi Shusheng Zhang Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers College of Chemistry and Chemical EngineeringLinyi UniversityLinyiShandong 276005China

Nanopore sensing is developing into a powerful label-free approach to investigate the features of biomolecules at the single-molecule *** a charged molecule is captured within a nanopore,it modulates the ionic current,which can be recorded in real time to reveal the properties of the target *** date,nanopores have been used to sense a variety of analytes,including DNA,RNA,proteins,enzymes,small molecules,cancer cells,and metal ions,and can also provide information on biomolecular *** this review,we highlight the progress made in nanopore sensing over the past five years(2016-2020),and provide an outlook on future developments and directions in the field.

关键词： ion channels Biosensors Nanopore Biomolecule Single-molecule studies

Antibody Therapies Targeting Complex Membrane Proteins

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2021年第11期7卷 1541-1551页

作者： Georgina To’a Salazar Ziyi Huang Ningyan Zhang Xue-Guang Zhang Zhiqiang An Texas Therapeutics Institute Brown Foundation Institute of Molecular MedicineThe University of Texas Health Science Center at HoustonHoustonTX 77030USA Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Clinical Immunology Soochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology The First Affiliation Hospital of Soochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China

In analyses of protein families that may serve as drug targets,membrane-associated G-protein-coupled receptors(GPCRs)dominate,followed by ion channels,transporters,and—to a lesser extent—membrane-bound ***,various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic *** hold the promise of exquisite specificity,as they are able to target even specific conformations of a particular membrane protein,as well as adaptability through engineering into various antibody ***,the ease of raising and isolating specific,effective antibodies targeting membrane proteins depends on many *** particular,the generation of specific antibodies is easier when targeting larger,simpler,extracellular domains with greater uniqueness of amino acid *** rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane *** in developing antibodies to complex membrane proteins such as GPCRs,ion channels,transporters,and membrane-bound enzymes can be addressed by the design of the antigen,antibody-generation strategies,lead optimization technologies,and antibody modalities.A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug *** review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation,illustrated by select examples of success.

关键词： Antibody therapy Complex membrane protein ion channels Transporters Membrane-bound enzymes GPCRs Drug discovery

The molecular dynamics of neural metabolism during the action potential

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2014年第5期57卷 857-863页

作者： ZHENG HongWen WANG RuBin QIAO LinKun DU Ying The Institute for Cognitive Neurodynamics East China University of Science and Technology The Institute of Biological Engineering East China University of Science and Technology

Neural information processing is tightly coupled to both energy consumption and derivation from *** this study,the energy function of the neuron during the action potential(AP)is described and *** has been observed that energy consumption during the AP does not match predictions of the conventional theory of neural energy *** short time scales,neural energy expenditure shifts between positive and negative *** the AP,the energy source switches from neuronal stores(positive expenditure or net consumption)to exploitation of external substrates,specifically the glucose and oxygen carried in cerebral blood(the negative consumption phase).Based on the idea of reductionism,this paper demonstrates how ion channels,membrane pumps and transporters,ionotropic and metabotropic receptor signaling pathways,astrocyte glycolysis and the production lactate,and the glutamate-glutamine cycle all serve to relate cerebral blood flow and neuronal metabolism to neuronal activity and so maintain neuronal energy charge during the AP.

关键词： neural energy action potential ion channels astrocytes hyperaemia

Water wettability in nanoconfined environment

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 836-843页

作者： ZHOU YaHong GUO Wei JIANG Lei Beijing National Laboratory for Molecular Sciences (BNLMS) Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of Sciences

Water confined in nanoscale space behaves quite differently from that in the *** example,in biological aquaporins and in carbon nanotubes,the traversing water molecules form a single file *** would stay in vapor state in extremely hydrophobic narrow nanopores owing to the physicochemical interactions between the water molecules and the surface of the nanopore.A spontaneous wet-dry transition has been identified in both biological and artificial *** nanopore is either fulfilled with liquid water or completely *** on this mechanism,the wetting and dewetting processes inside nanopores have been further developed into highly efficient nanofluidic gates that can be switched by external stimuli,such as light irradiation,electric potential,temperature,and mechanical *** review briefly covers the recent progress in the special wettability in nanoconfined environment,water transportation through biological or artificial nanochannels,as well as the smart nanofluidic gating system controlled by the water wettability.

关键词： wettability nanopore hydrophobic interaction ion channels gating