检索结果-南通市图书馆

A new therapeutic approach to erectile dysfunction： urotensin-II receptor high affinity agonist ligands

Asian Journal of Andrology 2015年第1期17卷 81-85,I0008,I0009页

作者： Roberta d'Emmanuele di Villa Bianca Emma Mitidieri Erminia Donnarumma Ferdinando Fusco Nicola Longo Giuseppe De Rosa Ettore Novellino Paolo Grieco Vincenzo Mirone Giuseppe Cirino Raffaella Sorrentino Department of Pharmacy University of Naples Federico II Via D. Montesano 49 Naples Italy Interdepartmental Centre for Sexual Medicine University of Naples Federico II Via S. Pansini 5 Naples Italy Department of Neurosciences Human Reproduction and Odontostomatology University of Naples Federico II Via S. Pansini 5 Naples Italy.

Urotensin-II （U-II） is a cyclic peptide that acts through a G protein-coupled receptor （urotensin-II receptor [UTR]） mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure （ICP） in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U （H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH） and UPG84（H-Asp-c[Pen-Phe-DTrp-Orn-（pNH2） Phe-Cys]-Val-OH）. The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. intracavernous injection of U-II （0.03-1 nmol）, P5U （0.03-1 nmol） or UPG84 （0.03-1 nmol） caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose （0.03 nmol） showed an effect similar to the highest dose of U-II （1 nmol）. Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U （0.03 nmol） did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.

关键词： erectile dysfunction intracavernous pressure rat urotensin-II urotensin-II ligands

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury

引用

Neural Regeneration Research 2016年第8期11卷 1312-1321页

作者： Zhan-kui Zhao Hong-lian Yu Bo Liu Hui Wang Qiong Luo Xie-gang Ding Department of Urology Zhongnan HospitalWuhan University Department of Urology Affiliated Hospital of Jining Medical University Department of Medical Biochemistry Basic Medical SchoolJining Medical University Department of Nutrition and Food Health School of Public HealthWuhan University

Polysaccharides extracted from Lycium barbarum exhibit antioxidant *** hypothesized that these polysaccharides resist oxidative stress-induced neuronal damage following cavernous nerve *** this study,rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1,7,and 14 days after cavernous nerve *** superoxide dismutase and glutathione peroxidase activities significantly increased at 1 and 2 weeks *** malondialdehyde levels decreased at 2 and 4 *** 12 weeks,peak intracavernous pressure,the number of myelinated axons and nicotinamide adenine dinucleotide phosphate-diaphorase-positive nerve fibers,levels of phospho-endothelial nitric oxide synthase protein and 3-nitrotyrosine were higher in rats administered at 1 day post-injury compared with rats administered at 7 and 14 days *** findings suggest that application of Lycium barbarum polysaccharides following cavernous nerve crush injury effectively promotes nerve regeneration and erectile functional *** neuroregenerative effect was most effective in rats orally administered Lycium barbarum polysaccharides at 1 day after cavernous nerve crush injury.

关键词： nerve regeneration erectile dysfunction cavernous nerve Lycium barbarum polysaccharides oxidative stress superoxide dismutase glutathione peroxidase malondialdehyde intracavernous pressure neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pancreatic kininogenase improves erectile function in streptozotocin-induced type 2 diabetic rats with erectile dysfunction

引用

Asian Journal of Andrology 2018年第5期20卷 448-453页

作者： Guo-Tao Chen Bai-Bing Yang Jian-Huai Chen Zheng Zhang Lei-Lei Zhu He-Song Jiang Wen Yu Yun Chen Yu-Tian Dai Department of Andrology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China.

Erectile dysfunction （ED） associated with type 2 diabetes is a severe problem that requires effective treatment. Pancreatic kininogenase （PK） has the potential to improve the erectile function of ED patients. This study aims to investigate the effect of PK on erectile function in streptozotocin-induced type 2 diabetic ED rats. To achieve this goal, we divided male Sprague-Dawley rats into five groups. One group was not treated, and the other four groups were treated with saline, sildenafil, PK or sildenafil, and PK, respectively, for 4 weeks after the induction of type 2 diabetic ED. Then, intracavernous pressure under cavernous nerve stimulation was measured, and penile tissue was collected for further study. Endothelial nitric oxide synthase levels, smooth muscle content, endothelium content, cyclic guanosine monophosphate （cGMP） levels in the corpus cavernosum, and neuronal nitric oxide synthase levels in the dorsal penile nerve were measured. Improved erectile function and endothelium and smooth muscle content in the corpus cavernosum were observed in diabetic ED rats. When treating diabetic ED rats with PK and sildenafil at the same time, a better therapeutic effect was achieved. These data demonstrate that intraperitoneal injection of PK can improve erectile function in a rat model of type 2 diabetic ED. With further research on specific mechanisms of erectile function improvement, PK may become a novel treatment for diabetic ED.

关键词： cyclic guanosine monophosphate endothelial nitric oxide synthase erectile dysfunction intracavernous pressure pancreatic kininogenase type 2 diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal models for studying penile hemodynamics

引用

Asian Journal of Andrology 2002年第3期4卷 225-228页

作者： Hiroya Mizusawa Osamu Ishizuka Osamu Nishizawa Department of Urology National Nagano Hospital 1-27-21 Midorigaoka Ueda 386 0022 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390 8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390 8621 Japan

Animal models for the study of erectile function monitoring the changes in intracavernous pressure (ICP) during penile erection was reviewed. The development of new models using small commercially-available experimental animals, rats and mice, in the last decade facilitated in vivo investigation of erectile physiology. The techniqueenabled to evaluate even subtle erectile responses by analyzing ICP and systemic blood pressure. Moreover, the method has been well improved and studies using conscious animal models without the influence of any drug or anesthesia are more appropriate in exploring the precise physiological and pharmacological mechanisms in erection. Also, more natural and physiological sexual arousal instead of electrical or pharmacological stimulation is desirable in most of the *** article reviewed the development of ICP studies in rats and mice.

关键词： erectile dysfunction impotence intracavernous pressure sexual dysfunction corpus cavernosum electrophysiology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Erectile potentials of a new phosphodiesterase type 5 inhibitor,DA-8159,in diet-induced obese rats

引用

Asian Journal of Andrology 2006年第3期8卷 325-329,388页

作者： Jae-YoungYu Kyung-KooKang MoohiYoo Research Institutes of Dong A Pharmaceutical Company KiheungYounginKyunggi 449-905Korea

Aim:To examine the changes in the erectile function in diet-induced obese rats and investigate the oral efficacy of DA-8159,a new phosphodiesterase type 5(PDE5)inhibitor,on penile erection in obese ***:The rats were fed a high-energy diet for 12 weeks and divided into three groups:an obesity-resistant(OR)control group,an obesity- prone(OP)control group,and an OP-DA-8159 treatment(DA-8159)*** electrostimulation-induced erectile responses were measured in all *** body weight,plasma cholesterol,triglyceride and glucose levels were also ***:In the OP control group,the maximum intracavernous pressure(ICP)and ICP/blood pressure(ICP/BP)ratio after electric stimulation were significantly lower than those in OR control *** corresponding area under the curve(AUC)of the ICP/BP ratio,the detumescence time and the baseline cavernous pressure were also lower than those in the OR control group,but this difference was not *** body weight gain,plasma cholesterol and triglyceride level in the OP group were significantly higher than those in the OR group. After administering the DA-8159,a significant increase in the maximum ICP and the ICP/BP ratio were *** coerrsponding AUCs in the DA-8159 group were also higher than those in the two control ***,the detumescence time was significantly prolonged after treatment with ***:These results demon- strate that diet-induced obesity affects the erectile function in rats and these erectile dysfunction(ED)can be im- proved by the treatment with DA-8159,indicating DA-8159 might be a treatment option for ED associated with obesity.

关键词： phosphodiesterase type 5 inhibitor penile erection obesity DA-8159 intracavernous pressure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：