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Identification of a Morphogenic intermediate of the Bacteriophage Mu Baseplate

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Advances in Microbiology 2014年第16期4卷 1155-1163页

作者： Nao Tsukamoto Yuko Kanazawa Yuzuki Shimamori Keiko Yoshida Shigeki Takeda Faculty of Science and Technology Division of Molecular Science Gunma University Gunma Japan

Bacteriophage morphogenesis is a model system for investigating sequential molecular assembly. The Mu phage is one of the most classical Myoviridae. Although it is well known as a mobile genetic element, the details of its morphogenesis remain unclear. Analysis of conditional lethal mutants and genome analysis of the Mu phage have suggested that genes 42, 43, 44, 45, 46, 47, and 48 are essential for its baseplate assembly. Since we have already reported X-ray structures of the products of genes 44 (gp44) and 45 (gp45), we here tried to purify the remaining Mu phage baseplate subunits, gp42, gp43, gp46, gp47, and gp48, to investigate the baseplate assembly process. In the case of gp42 expression, the transformed E. coli cells showed growth inhibition after induction and no gp42 fractions were observed. However, gp43, gp46, gp47, and gp48 were successfully expressed and purified, although gp48 could not be applied to further analysis, because the amount of soluble fraction was very low. Based on analytical ultracentrifugation, we concluded that gp43 formed a monomer, gp46 was a monomer, and gp47 occurred as both a monomer and dimer in solution. Moreover, we found that gp43 and gp45 formed an intermediate complex in the baseplate assembly process.

关键词： Bacteriophage Baseplate Self-Assembly Assembly intermediate Analytical Ultracentrifugation

Synthesis and X-Ray Structure of Important Anticancer Nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate

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Journal of Crystallization Process and Technology 2014年第3期4卷 140-144页

作者： Yang Liu Guanghui Tian Hongguang Ge Xiaoyan Cao Daihua Hu Dehua Zhang Department of Chemistry and Environmental Engineering Hubei Normal University Huangshi China School of Chemistry and Environmental Science Shaanxi University of Technology Hanzhong China

An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

关键词： Anticancer Nucleosides intermediate Triazole Nucleosides

Synthesis of intermediate N-Chloroformyl-N-[4-(trifluoromethoxy)phenyl]Methyl Carbamate of Indoxacarb

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Plant Diseases and Pests 2020年第1期11卷 36-40页

作者： Zhang Zhenming Kong Xianbin Wang Gang Wang Xiaohui Liu Minjin Jiangsu Changqing Agrochemical Co. Ltd.Yangzhou 225000China Shenyang Research Institute of Chemical Industry Co. Ltd.Shenyang 110021China

[Objective]The paper was to study a synthetic method suitable for industrial production of intermediate N-Chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl carbamate of indoxacarb.[Method]Using 4-trifluoromethoxy aniline as the starting material,[4-(trifluoromethoxy)phenyl]carbamate was synthesized by homogeneous formylation method without acid-binding ***,it was reacted with sodium methoxide/potassium methoxide by reactive distillation to obtain[4-(trifluoromethoxy)phenyl]carbamate ammonium sodium/potassium,then directly reacted with triphosgene to obtain crude products of N-carbonochloridoyl-N-[4-(trifluoromethoxy)phenyl]carbamate;finally,competing product was obtained by recrystallization.[Result]The intermediate N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]carbamate was synthesized by the *** content of products was higher than 98%.The yield of product reached above 96%(calculated by 4-trifluoromethoxy aniline).[Conclusion]The method used for the synthesis of intermediate N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl carbamate was simple,with less three wastes,higher safety and lower cost.

关键词： Indoxacarb intermediate N-chloroformyl-N-[4-(trifluoromethoxy)phenyl]methyl carbamate Synthesis Sodium/potassium ammonium salt Formylation Recrystallization

Daqing Petrochemical Conducts intermediate Handing-over on Hexene-1 Project

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China Chemical Reporter 2008年第20期19卷 19-19页

On June 30th,2008 PetroChina Daqing Petrochemical Co.,*** intermediate handing-over on its 5000 t/a Hexene-l projectIn June 2007 PetroChina decided to make an investment of RMB74 million on launching a 5000 t/a hexene... 详细信息

关键词： decided intermediate launching

Combined cryotherapy and external beam radiation therapy for the treatment of intermediate-risk localized prostate cancer: A case series

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Case Reports in Clinical Medicine 2014年第1期3卷 47-51页

作者： Peter Qi Matvey Tsivian Zeljko Vujaskovic Thomas J. Polascik Department of Radiation Oncology Duke University Medical Center Durham USA Division of Urology Department of Surgery Duke University Medical Center Durham USA

Introduction: Routine PSA screening for prostate cancer (PCa) has increased the detection of intermediate-risk, localized disease. Conventional treatments for localized PCa include surgery, brachytherapy, cryotherapy or external beam radiotherapy (EBRT). However, for intermediate risk patients, rates of recurrence are moderately high and a multi-modal treatment approach for these patients may be necessary. We treated patients with a combination of cryotherapy and low dose EBRT to assess the safety and feasibility of this combinatory approach as well as to evaluate early oncological outcomes. Case Presentation: Men with intermediate risk (PSA = 10-20 ng/ml and/or Gleason = 7 and/or clinical T2b) localized PCa were prospectively enrolled in this study. Patients underwent cryotherapy and then 39 Gy EBRT 4-6 weeks after surgery. After completing EBRT, the men were followed every 3 months for 2 years. Adverse events, PSA, urinary and erectile function were assessed during each follow-up. Three patients completed the study. Preoperative PSA ranged from 3.5 to 7.9 ng/ml. There were no intraoperative complications and the treatment was well tolerated. Following cryotherapy and EBRT, all patients were pad-free within 6 months and remained continent for the duration of the study. Bother index remained stable throughout the study for all patients. No urethral strictures or rectal toxicities were observed. PSA remained undetectable for all patients. Conclusions: In this prospective study, cryotherapy combined with low dose EBRT was a safe approach for the treatment of intermediate-risk, localized PCa. Early oncological outcomes appeared to be favorable with all patients having undetectable PSA during the 2-year follow-up period. Further studies are warranted to confirm these preliminary results.

关键词： External Beam Radiation Cryotherapy Localized Prostate Cancer intermediate Risk

Investigation of I MF Multiplicityin intermediate Energy HeavyIon Collision

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IMP & HIRFL Annual Report 1997年 17-18页

Neck Formation and Decay in intermediate Energy HIC

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IMP & HIRFL Annual Report 1996年第1期 138-139页

作者： Chen Liewen Ge Lingxiao and Zhang Fengshou

ＮｅｃｋＦｏｒｍａｔｉｏｎａｎｄＤｅｃａｙｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒｇｙＨＩＣ￥ＣｈｅｎＬｉｅｗｅｎ；ＧｅＬｉｎｇｘｉａｏａｎｄＺｈａｎｇＦｅｎｇｓｈｏｕＩｎｒｅｃｅｎｔｙｅａｒｓ，ｐｅｏｐｌｅｆｏｕｎｄｔ... 详细信息

ＮｅｃｋＦｏｒｍａｔｉｏｎａｎｄＤｅｃａｙｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒｇｙＨＩＣ￥ＣｈｅｎＬｉｅｗｅｎ；ＧｅＬｉｎｇｘｉａｏａｎｄＺｈａｎｇＦｅｎｇｓｈｏｕＩｎｒｅｃｅｎｔｙｅａｒｓ，ｐｅｏｐｌｅｆｏｕｎｄｔｈａｔｔｈｅｓｈａｐｅｉｎｓｔａｂ...

关键词： intermediate

Evaporation　of　intermediate－mass　Fragments　from　Hot－nuclei　Produced　by　25MeV／u　^（40）Ar　Bombarding　^（159）Tb　Target

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IMP & HIRFL Annual Report 1994年 14-15页

作者： Jiang Dongxing Qian Xing Qian Tao Hua Hui Lin Junsong Wu Enjiu Zheng Jiwen Jing Genming Yin Shuzhi Tan Jilin Jing Weiyang Song Mingtao Li Zuyu and He Zhiyong

ＥｖａｐｏｒａｔｉｏｎｏｆＩｎｔｅｒｍｅｄｉａｔｅ－ｍａｓｓＦｒａｇｍｅｎｔｓｆｒｏｍＨｏｔ－ｎｕｃｌｅｉＰｒｏｄｕｃｅｄｂｙ２５ＭｅＶ／ｕ^（４０）ＡｒＢｏｍｂａｒｄｉｎｇ^（１５９）ＴｂＴａｒｇ... 详细信息

ＥｖａｐｏｒａｔｉｏｎｏｆＩｎｔｅｒｍｅｄｉａｔｅ－ｍａｓｓＦｒａｇｍｅｎｔｓｆｒｏｍＨｏｔ－ｎｕｃｌｅｉＰｒｏｄｕｃｅｄｂｙ２５ＭｅＶ／ｕ^（４０）ＡｒＢｏｍｂａｒｄｉｎｇ^（１５９）ＴｂＴａｒｇｅｔ￥ＪｉａｎｇＤｏｎｇｘｉｎｇ；...

关键词： nuclei intermediate Evaporation Fragments Hot Ar MeV Produced Target Tb

Nucleon Chaotic Behavior in intermediate Energy Heavy Ion Collisions

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IMP & HIRFL Annual Report 1995年 108-109页

作者： Yuan Xiuqing and Li Junqing

Ｎｕｃｌｅｏｎ　Ｃｈａｏｔｉｃ　Ｂｅｈａｖｉｏｒ　ｉｎ　Ｉｎｔｅｒｍｅｄｉａｔｅ　Ｅｎｅｒｇｙ　Ｈｅａｖｙ　Ｉｏｎ　ＣｏｌｌｉｓｉｏｎｓＮｕｃｌｅｏｎＣｈａｏｔｉｃＢｅｈａｖｉｏｒｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒ... 详细信息

Ｎｕｃｌｅｏｎ　Ｃｈａｏｔｉｃ　Ｂｅｈａｖｉｏｒ　ｉｎ　Ｉｎｔｅｒｍｅｄｉａｔｅ　Ｅｎｅｒｇｙ　Ｈｅａｖｙ　Ｉｏｎ　ＣｏｌｌｉｓｉｏｎｓＮｕｃｌｅｏｎＣｈａｏｔｉｃＢｅｈａｖｉｏｒｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒｇｙＨｅａｖｙＩｏｎＣｏｌｌｉｓｉ...

关键词： intermediate