Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1<i>H</i>-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1<i>H</i>-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate作者机构：Department of Chemistry and Environmental Engineering Hubei Normal University Huangshi China School of Chemistry and Environmental Science Shaanxi University of Technology Hanzhong China
出 版 物：《Journal of Crystallization Process and Technology》 (结晶过程及技术期刊（英文）)
年 卷 期：2014年第4卷第3期
页 面：140-144页
主 题：Anticancer Nucleosides Intermediate Triazole Nucleosides
摘 要：An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.
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