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Effect of Acupuncture-moxibustion on the Expression of iGF-1 and SOCS2 in Colonic Mucosa of Rats with Ulcerative Colitis

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Journal of Acupuncture and Tuina Science 2010年第4期8卷 204-209页

作者：王晓梅关鑫季光施征吴焕淦 Shanghai University of Traditional Chinese Medicine Shanghai 201203 E R. China

Objective： To observe the effect of acupuncture-moxibustion on the expression of insulin-like growth factor-i （iGF-i） and suppressor of cytokine signaling-2 （SOCS2） in colonic mucosa of rat models of ulcerative colitis （UC）, and explore the mechanism of acupuncture- moxibustion therapy in treating UC. Methods： The rats were randomized into a normal control （NC） group, a model control （MC） group, an herb-partitioned moxibustion （HPM） group and an electroacupuncture （EA） group, 8 in each group. The rat models of UC were established by immunological methods combined with local stimulation. The rats in the HPM and EA groups were given herb-partitioned moxibustion and electroacupuncture treatments respectively, once every day, lasting for 14 d. The morphological variations of rat＇s colonic mucosa were observed under light microscope; the colonic mucosal mucin was detected by PAS-AB and HiD-AB staining methods; the expression of iGF-1 and SOCS2 was assayed by the immunohistochemical method. Results： in the rat models of UC, ulceration and inflammation of the colon were revealed by light microscope. The concentration of colonic mucosal mucin was reduced （P〈0.01）, while the expression of iGF-1 had an increase （P〈0.01）, and the expression of SOCS2 was reduced （P〈0.01）. After HPM or EA treatment, the pathological injuries of colonic mucosa had improved, the concentration of mucin increased （P〈0.01）, the expression of iGF-1 decreased （P〈0.01）, and the expression of SOCS2 increased （P〈0.01）. Conclusion： The secretion of mucosal mucin in rat UC decreased, the expression of iGF-1 was significantly higher, while the expression of SOCS2 was remarkably lower; both HPM and EA can help improve the damage of colonic mucosa in rat UC, and modulate the secretion of mucin, as well as regulate the expression of iGF-1 and SOCS2 in the colonic mucosa.

关键词： Colitis, Ulcerative Acupuncture-moxibustion Therapy insulin-like growth factor i Suppressor of Cytokine Signaling Proteins

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Changes of osteocalcin and iGF-i during bone lengthening

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Chinese Journal of Traumatology 2005年第3期8卷 151-155页

作者：王兵刘贻运郑介柏袁士翔陈国勋 Department of Orthopedics of 12th Hospital of Guangzhou Guangdong 510620 China

Objective: To examine the changes of osteocalcin and insulin-like growth factor i (iGF-i) during bone lengthening, and to clarify the mechanism of bone healing. Methods: Thirty-two shepherd dogs were divided into five groups randomly. Their tibiae were lengthened by ilvzarov’s external fixator at the rate of 1 mm/day. The lengthening area was the experimental side and the opposite side was the control. Samples were obtained on the 2nd, 4th, 6th, 8th, 12th weekend respectively. The samples were defatted, dried, powdered, centrifuged and measured by radioimmunoassay. Results: The osteocalcin concentration increased at the subsequent periods, but it was significantly lower in the experimental side than that of the control side, PiGF-i concentration was not significantly lowered. Conclusions: Different noncollagenous bone growth factors may be different at different stage.

关键词： Bone lengthening Osteocalcin insulin-like growth factor i

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initial research of cord blood leptin, adiponectin and iGF-i with fetus growth and development

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Discussion of Clinical Cases 2016年第1期3卷 16-19页

作者： Yan Sun Junli Li Yajing Zhang Department of Pediatrics The Baogang HospitalBaotouInner MongoliaChina

Objective:in order to reveal the relationship between cord blood leptin,adiponectin and insulin-like growth factor-i(iGF-i)and the fetus growth and development,and discuss the interaction and clinical significance on fetus growth and ***:The levels of cord blood leptin,adiponectin,iGF-i in 86 newborns were examined by radio immunoassay,according to gestation age and birth weight percentile relation,the objects were divided into the SGA group(n=16),the AGA group(n=41),the LGA group(n=29),meanwhile,neonatal birth weight,body length,head circumference,foot length,and placental weight were measured,and body mass index(BMi)was *** analysis was ***:The levels of cord blood leptin,adiponectin and iGF-i were as follows:LGA group>AGA group>SGA *** level of cord blood adiponectin was positively correlated with birth weight,placental weight and BMi(pin and iGF-i concentrations were positively correlated with their birth weight,body length,head circumference,foot length,placental weight and BMi,respectively(pin was positively correlated with adiponectin and iGF-i(pin and adiponectin had no statistical significance with neonatal sexuality and deliver style(p>.05);the levels of cord blood iGF-i had no statistical significance with neonatal sexuality(p>.05),but had statistical significance with deliver style(pions:Cord blood leptin,adiponectin and iGF-i played an important part in adjusting fetus growth and development as well as participating in the process of fetus growth and development,and could be regarded as one of the clinical indexes to evaluate fetus growth and development or state of *** abnormal level of cord blood leptin and iGF-i might be one of the reasons to cause intrauterine growth retardation and fetal macrosomia.

关键词： Leptin Adiponectin insulin-like growth factor i Cord blood Fetus growth and development

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