Changes of osteocalcin and IGF-I during bone lengthening
Changes of osteocalcin and IGF-I during bone lengthening作者机构：Department of Orthopedics of 12th Hospital of Guangzhou Guangdong 510620 China
出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)
年 卷 期：2005年第8卷第3期
页 面：151-155页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Bone lengthening Osteocalcin Insulin-like growth factor I
摘 要：Objective: To examine the changes of osteocalcin and insulin-like growth factor I (IGF-I) during bone lengthening, and to clarify the mechanism of bone healing. Methods: Thirty-two shepherd dogs were divided into five groups randomly. Their tibiae were lengthened by Ilvzarov’s external fixator at the rate of 1 mm/day. The lengthening area was the experimental side and the opposite side was the control. Samples were obtained on the 2nd, 4th, 6th, 8th, 12th weekend respectively. The samples were defatted, dried, powdered, centrifuged and measured by radioimmunoassay. Results: The osteocalcin concentration increased at the subsequent periods, but it was significantly lower in the experimental side than that of the control side, P(0.05) and the IGF-I concentration was not significantly lowered. Conclusions: Different noncollagenous bone growth factors may be different at different stage.
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