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Animal Models and Experimental Medicine 2025年第1期8卷 57-66页

作者： Yun Liu Ting-Ting Feng Wei Tong Zhi Guo Xia Li Qi Kong Zhi-Guang Xiang Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingP.R.China

Background:Macrophages are the primary innate immune cells encountered by the invading coronaviruses,and their abilities to initiate inflammatory reactions,to main-tain the immunity homeostasis by differential polarization,to train the innate immune system by epigenic modification have been reported in laboratory animal ***:In the current in vitro research,murine macrophage RAW 264.7 cell were infected by mouse hepatitis virus,a coronavirus existed in *** 3-,6-,12-,24-,and 48-h post infection(hpi.),the attached cells were washed with PBS and harvested in Trizol *** The harvest is subjected to transcriptome ***:The transcriptome analysis showed the immediate(3 hpi.)up regulation of DEGs related to inflammation,like Il1b and *** related to M2 differential po-larization,like Irf4 showed up regulation at 24 hpi.,the late term after viral *** addition,DEGs related to metabolism and histone modification,like Ezh2 were de-tected,which might correlate with the trained immunity of ***:The current in vitro viral infection study showed the key innated im-munity character of macrophages,which suggested the replacement value of viral infection cells model,to reduce the animal usage in preclinical research.

关键词： coronavirus innate immunity macrophage transcriptome

innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

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World Journal of Clinical Cases 2021年第23期9卷 6686-6697页

作者： Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu Department of Pediatrics I “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Pediatrics III “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Pathology Emergency County Hospital Târgu MureșTârgu Mureș540139Romania Scientific Medical Research Methodology “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Genetics Center for Advanced Medical and Pharmaceutical Research“George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania

BACKGROUND innate immunity was found to be associated with both persistence of Helicobacter pylori(***)infection and increased risk of gastric *** To identify the risk factors associated with *** infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in *** We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with ***-induced chronic gastritis,and Group 2–control *** Rural area and poor living conditions were significantly associated with *** chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti *** and the rapid urease test were significantly associated with *** infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with *** chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation.

关键词： innate immunity Helicobacter pylori infection Children Chronic gastritis TLR9 Systemic inflammation

Induction of innate immunity and its perturbation by influenza viruses

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Protein & Cell 2015年第10期6卷 712-721页

作者： Mohsan Ullah Goraya Song Wang Muhammad Munir Ji-Long Chen College of Animal Science Fujian Agriculture and Forestry University Fuzhou 350002 China The Pirbright Institute Ash Road Pirbright Woking GU24 0NF UK CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China

Influenza A viruses （IAV） are highly contagious patho- gens causing dreadful losses to human and animal, around the globe. IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5＇-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways. These induced immune responses establish the antiviral state of the host for effective suppression of viral replication and enhancing viral clearance. However, IAVs have evolved a variety of mechanisms by which they can invade host cells, circumvent the host immune responses, and use the machineries of host cells to synthesize and transport their own components, which help them to establish a successful infection and repli- cation. In this review, we will highlight the molecular mechanisms of how IAV infection stimulates the host innate immune system and strategies by which IAV evades host responses.

关键词： influenza A virus innate immunity immuneescape

Caspases control antiviral innate immunity

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Cellular & Molecular Immunology 2017年第9期14卷 736-747页

作者： Huihui Chen Xiaohan Ning Zhengfan Jiang Shenzhen BOLI Pharmaceutical Co. LtdShenzhenGuangdong 518040China State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Beijing 100871China

Caspases are a family of cysteine proteases whose functions have been scrutinized intensively in recent *** their established roles in programmed cell death and inflammatory response,some caspases are also fundamental players in antiviral immunity by fine-tuning the levels of antiviral signaling adapters and cytokines,such as type I interferons,which serves as a major,sophisticated weapon against *** infections can result in inflammasome activation and the initiation of cell death,including apoptosis and pyroptosis,and multiple caspases are significantly involved in these *** review will focus on the cutting-edge discoveries regarding the multifaceted roles of caspases in antiviral innate immunity.

关键词： apoptosis caspases I-IFNs inflammasome innate immunity

Ca&Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening

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Bioactive Materials 2024年第3期33卷 483-496页

作者： Xi Deng Tianzhi Liu Yutong Zhu Jufeng Chen Ze Song Zhangpeng Shi Hangrong Chen State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024PR China Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai200072PR China

Limited by low tumor immunogenicity and the immunosuppressive tumor microenvironment(TME),triple-negative breast cancer(TNBC)has been poorly responsive to immunotherapy so ***,a Ca&Mn dual-ion hybrid nanostimulator(CMS)is constructed to enhance anti-tumor immunity through ferroptosis inducing and innate immunity awakening,which can serve as a ferroptosis inducer and immunoadjuvant for TNBC *** one hand,glutathione(GSH)depletion and reactive oxygen species(ROS)generation can be achieved due to the mixed valence state of Mn in *** the other hand,as an exotic Ca2+supplier,CMS causes mitochondrial Ca2+overload,which further amplifies the oxidative ***,tumor cells undergo ferroptosis because of the inactivation of glutathione peroxidase 4(GPX4)and accumulation of lipid peroxidation(LPO).More impressively,CMS can act as an immunoadjuvant to awaken innate immunity by alleviating intra-tumor hypoxia and Mn2+-induced activation of the STING signaling pathway,which promotes polarization of tumor-associated macrophages(TAMs)and activation of dendritic cells(DCs)for antigen presentation and subsequent infiltration of tumor-specific cytotoxic T lymphocytes(CTLs)into tumor *** together,this work demonstrates a novel strategy of simultaneously inducing ferroptosis and awakening innate immunity,offering a new perspective for effective tumor immunotherapy of TNBC.

关键词： Immunotherapy Ferroptosis innate immunity STING signaling pathway Calcium carbonate nanoparticles Manganese

Mitochondrial Regulation of Macrophages in innate immunity and Diverse Roles of Macrophages During Cochlear Inflammation

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Neuroscience Bulletin 2024年第2期40卷 255-267页

作者： Yuan Zhang Fanglei Ye Xiaolong Fu Shen Li Le Wang Yutian Chen Hongmin Li Shaojuan Hao Kun Zhao Qi Feng Peipei Li Department of Otology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Shandong Provincial Hospital Shandong First Medical UniversityJinan 250000China Department of Neurology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Department of Endovascular Surgery The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Integrated Traditional and Western Nephrology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Province Research Center of Kidney Disease Zhengzhou 450052China

Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and *** regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear *** distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related ***,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains ***,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune *** particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic *** hope this review will provide new perspectives and a basis for future research on cochlear inflammation.

关键词： Macrophage Mitochondria innate immunity Cochlea Infammation

Adiponectin:a versatile player of innate immunity

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Journal of Molecular Cell Biology 2016年第2期8卷 120-128页

作者： Yan Luo Meilian Liu Institute of Metabolism and Endocrinology Metabolic Syndrome Research Centerthe Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Biochemistry and Molecular Biology University of New Mexico Health Sciences CenterAlbuquerqueNM 87131USA

Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic *** and monocytes are representative components of the innate immune system,and their proliferation,plasticity,and polarization are a key component of metabolic ***-like lymphocytes such as group 2 innate lymphoid cells(ILC2s),natural killer T(NKT)cells,and gamma delta T(gd T)cells are also members of the innate immune system and play important roles in the development of obesity and its related *** senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological *** the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention.

关键词： adiponectin innate immunity macrophage innate-like lymphocyte

Dynamic modulation of innate immunity programming and memory

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Science China(Life Sciences) 2016年第1期59卷 38-43页

作者： Ruoxi Yuan Liwu Li Department of Biological Science Pathobiology and Biomedical Sciences Virginia Tech

Recent progress harkens back to the old theme of immune memory, except this time in the area of innate immunity, to which traditional paradigm only prescribes a rudimentary first-line defense function with no memory. However, both in vitro and in vivo studies reveal that innate leukocytes may adopt distinct activation states such as priming, tolerance, and exhaustion, depending upon the history of prior challenges. The dynamic programming and potential memory of innate leukocytes may have far-reaching consequences in health and disease. This review aims to provide some salient features of innate programing and memory, patho-physiological consequences, underlying mechanisms, and current pressing issues.

关键词： innate immunity memory dynamics priming tolerance exhaustion resolving and non-resolving inflammation

The role of O-GlcNAcylation in innate immunity and inflammation

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Journal of Molecular Cell Biology 2022年第9期14卷 14-25页

作者： Yongqiang Wang Xiuwu Fang Shuai Wang Bin Wang Feng Chu Zhixin Tian Long Zhang Fangfang Zhou Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Centerfor Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China

O-linkedβ-N-acetylglucosaminylation(O-GlcNAcylation)is a highly dynamic and widespread post-translational modification(PTM)that regulates the activity,subcellular localization,and stability of target proteins.O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes:O-linked N-acetylglucosamine transferase and *** evidence indicates that O-GlcNAcylation plays critical roles in innate immunity,inflammatory signaling,and cancer development.O-GlcNAcylation usually occurs on serine/threonine residues,where it interacts with other PTMs,such as ***,it likely has a broad regulatory *** review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation.A more comprehensive understanding ofO-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.

关键词： innate immunity inflammation O-GlcNAcylation cancer

The role of innate immunity in diabetic nephropathy and their therapeutic consequences

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Journal of Pharmaceutical Analysis 2024年第1期14卷 39-51页

作者： Min Yang Chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a substantial number of individuals with diabetes worldwide. A gradual reduction in glomerular filtration and emergence of proteins in the urine are typical aspects of DN, ultimately resulting in renal failure. Mounting evidence suggests that immunological and inflammatory factors are crucial for the development of DN. Therefore, the activation of innate immunity by resident renal and immune cells is critical for initiating and perpetuating inflammation. Toll-like receptors (TLRs) are an important group of receptors that identify patterns and activate immune responses and inflammation. Meanwhile, inflammatory responses in the liver, pancreatic islets, and kidneys involve inflammasomes and chemokines that generate pro-inflammatory cytokines. Moreover, the activation of the complement cascade can be triggered by glycated proteins. This review highlights recent findings elucidating how the innate immune system contributes to tissue fibrosis and organ dysfunction, ultimately leading to renal failure. This review also discusses innovative approaches that can be utilized to modulate the innate immune responses in DN for therapeutic purposes.

关键词： innate immunity Diabetic nephropathy Inflammation Toll-like receptor Inflammasomes