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injury potentials associated with severity of acute spinal cord injury in an experimental rat model

Neural Regeneration Research 2011年第23期6卷 1780-1785页

作者： Suying Pan Guanghao Zhang Xiaolin Huo Jinzhu Bai Tao Song Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100190 China Graduate College of Chinese Academy of Sciences Beijing 100190 China Department of Spinal Surgery Beijing Boai Hospital China Rehabilitation Research Center Capital Medical University Beijing 100068 China

To investigate characteristics of injury potentials after different degrees of spinal cord injury in rats the present study established models of spinal cord contusion with severe, moderate, and mild degrees of injury. injury potential was measured in vivo using a direct current voltage amplification system. Results revealed that in the first 4 hours after acute spinal cord injury, initial amplitude of injury potential was greatest after severe injury, followed by moderate and mild injuries. Amplitude of injury potential decreased gradually with injury time, and the recession curve was logarithmic. Under the same degree of injuries, amplitude of rostral injury potential was generally less than caudal injury potential. Results suggested that injury potential reflected injury severity, because large initial amplitude of injury potential during the early injury stage implied severe injury.

关键词： injury potential degree of injury spinal cord injury neural regeneration

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Electrical stimulation modulates injury potentials in rats after spinal cord injury

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Neural Regeneration Research 2013年第27期8卷 2531-2539页

作者： Guanghao Zhang Xiaolin Huo Aihua Wang Changzhe Wu Cheng Zhang Jinzhu Bai Beijing Key Laboratory of Bioelectromagnetism Institute of Electrical EngineeringChinese Academy of Sciences Department of Spinal Surgery Beijing Boai HospitalChina Rehabilitation Research CenterCapital Medical University

An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This injury potential, as wel as injury current, can be modulated by direct current field stimulation;however, the appropriate parameters of the electrical field are hard to define. In this paper, injury potential is used as a parameter to adjust the intensity of electrical stimulation. injury potential could be modulated to slightly above 0 mV （as the anode-centered group） by placing the anodes at the site of the injured spinal cord and the cathodes at the rostral and caudal sections, or around-70 mV, which is resting membrane potential （as the cathode-centered group） by reversing the polarity of electrodes in the anode-centered group. In addition, rats receiving no electrical stimulation were used as the control group. Results showed that the absolute value of the injury potentials acquired after 30 minutes of electrical stimulation was higher than the control group rats and much lower than the initial absolute value, whether the anodes or the cathodes were placed at the site of injury. This phenomenon il ustrates that by changing the polarity of the electrical field, electrical stimulation can effectively modulate the injury potentials in rats after spinal cord injury. This is also beneficial for the spontaneous repair of the cel membrane and the reduction of cation influx.

关键词： neural regeneration spinal cord injury injury potential electrical stimulation electric parameters cations resting membrane potential neural regeneration electrode stimulator charge balance grants-supported paper neuroregeneration

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