Injury potentials associated with severity of acute spinal cord injury in an experimental rat model

作     者：Suying Pan Guanghao Zhang Xiaolin Huo Jinzhu Bai Tao Song 

作者机构：Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100190 China Graduate College of Chinese Academy of Sciences Beijing 100190 China Department of Spinal Surgery Beijing Boai Hospital China Rehabilitation Research Center Capital Medical University Beijing 100068 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第23期

页      面：1780-1785页

核心收录：

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：Science & Technology Program of Chinese Academy of Sciences for Disability,No.KGLX2-YW-613 the New Star Program of Beijing Science and Technology,No.2007B070 

主　　题：injury potential degree of injury spinal cord injury neural regeneration 

摘      要：To investigate characteristics of injury potentials after different degrees of spinal cord injury in rats the present study established models of spinal cord contusion with severe, moderate, and mild degrees of injury. Injury potential was measured in vivo using a direct current voltage amplification system. Results revealed that in the first 4 hours after acute spinal cord injury, initial amplitude of injury potential was greatest after severe injury, followed by moderate and mild injuries. Amplitude of injury potential decreased gradually with injury time, and the recession curve was logarithmic. Under the same degree of injuries, amplitude of rostral injury potential was generally less than caudal injury potential. Results suggested that injury potential reflected injury severity, because large initial amplitude of injury potential during the early injury stage implied severe injury.