检索结果-南通市图书馆

A new indole alkaloid from Nauclea officinalis(Pierre ex Pitard) Merr. et Chun

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2014年第5期23卷 306-310页

作者：皮晓雪谢可辉涂光忠蔡田芝杨蓉吴琼付宏征北京大学医学部天然药物与仿生药物国家重点实验室北京100191 北京微量化学研究所北京100191

From the aerial parts ofNauclea officinalis （Pierre ex Pitard） Merr. et Churl, one new indole alkaloid paratunamide E （1） has been isolated together with six known indole alkaloids, paratunamide A （2）, nauclealotide C （3）, nauclealotide A （4）, vincosamide （5）, strictosamide （6） and naucleamide F （7）. Naucleamide F （7） was isolated from Nauclea officinalis for the first time. All of the seven compounds above were elucidated by spectroscopic methods including 1 D and 2 D NMR soectroscoDic analyses.

关键词： Nauclea officinalis indole alkaloid Structural identification

indole alkaloids from the Roots of Ervatamia hainanensis

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第6期17卷 779-782页

作者： Jian Peng HUANG Zi Ming FENG Chong Fei ZHENG Pei Cheng ZHANG Yang Min MA Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 College of Life Science Northwest A-F University Yangling Shaanxi 712100

Two new indole alkaloids, named ibogamine-18-carboxylic acid, 3, 4-didehydro-7, 8-dioxo-methyl ester 1, ibogamine-18-carboxylic acid, 16, 17-didehydro-9, 17-dihydro-9-hydroxy （2-oxopropyl）-methyl ester 2, were isola... 详细信息

关键词： Ervatamia hainanensis indole alkaloid ibogamine-18-carboxylic acid 3 4-didehydro-7 8-dioxo-methyl ester ibogamine- 18-carboxylic acid 16 17-didehydro-9 17-dihydro-9-hydroxy-(2-oxopropyl)-methyl ester.

Antimicrobial indole alkaloids from Tabernaemontana corymbosa

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2023年第2期21卷 146-153页

作者： FAN Kun ZHANG Lanchun TAN Bangyin Guy S.S.Njateng QIN Malong GUO Ruirong HUANG Xiaojuan DING Cai-feng GAO Weimin ZHANG Rongping YU Haofei School of Pharmaceutical Sciences Department of Zoology&Yunnan Key Laboratory of Pharmacology for Natural ProductsKunming Medical UniversityKunming 650500China School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Resources Yunnan University of Traditional Chinese MedicineKunming 650500China Department of Biochemistry Faculty of ScienceUniversity of DschangDschangCameroon

Four unreported monoterpene indole alkaloids,tabernaecorymines B−E(1−4),together with twenty-one known indole alkaloids(5−25)were obtained from the stem bark of Tabernaemontana *** structures and absolute configurations were elucidated by extensive spectroscopy,quantum chemical calculations,DP4+probability analyses and Mo2(OAc)4-induced electronic circular dichroism *** antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis,Streptococcus dysgalactiae and Candida albicans.

关键词： Tabernaemontana corymbosa indole alkaloid Antimicrobial activity

Marine-derived fungi as a source of bioactive indole alkaloids with diversifed structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2021年第1期3卷 44-61页

作者： Zhi-Hui Meng Tian-Tian Sun Guo-Zheng Zhao Yu-Fei Yue Qing-Hua Chang Hua-Jie Zhu Fei Cao College of Pharmaceutical Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China

Marine-derived fungi are well known as rich sources of bioactive natural *** evidences indicated that indole alkaloids,isolated from a variety of marine-derived fungi,have attracted considerable attention for their diverse,challenging structural complexity and promising bioactivities,and therefore,indole alkaloids have potential to be pharmaceutical lead *** compilation of the relevant *** this review,we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities,covering literatures published during 1982–2019.

关键词： indole alkaloid Marine-derived fungus Chemical diversity Bioactivity

Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2022年第1期3卷 25-39页

作者： Xiao-Yu Liu Yong Qin Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610041 China

Asymmetric catalysis has continued to enable the preparation of optically active natural products over the past *** minireview summarizes progress in the catalytic enantioselective total synthesis of complex monoterpenoid indole alkaloids covering the reports from 2019 to June *** particular,the generation of the key chiral stereogenic centers with metal catalysts and organocatalysts has been highlighted,showcasing the power of asymmetric catalysis protocols in accessing complex molecular architectures.

关键词： Asymmetric catalysis Total synthesis indole alkaloid Natural product Enantioselectivity

Unified total synthesis of eburnamine-vincamine indole alkaloids based on catalytic asymmetric hydrogenation/lactamization cascade

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2022年第3期3卷 291-293页

作者： Wen Zhang Yansong Xue Srihari Konduri Guodan Lin Mengjuan Wu Pei Tang Fener Chen Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China Skaggs School of Pharmacy and Pharmaceutical Science UC San Diego9500 Gilman DriveLa JollaCA 92093-0934United States

The enantioselective total synthesis of representative members of the eburnamine-vincamine alkaloids(+)-vincamine,(-)-eburnamonine,and(-)-criocerine has been *** synthesis took advantage of a highly stereoselective Ir-catalyzed hydrogenation/lactamization cascade reaction,which allows for the stereo-selective construction of the C/D rings as well as the installation of the critical cis-C20/C21 relative stereo-chemistry of the eburnamine-vincamine alkaloid skeleton in one pot.

关键词： indole alkaloid Imine Asymmetric hydrogenation Natural product Enantioselective synthesis

alkaloid Accumulation in Catharanthus roseus Increases with Addition of Seawater Salts to the Nutrient Solution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2010年第6期20卷 718-724页

作者： WANG Jing-Yan and LIU Zhao-Pu College of Resources and Environmental Sciences,Nanjing Agricultural University,Nanjing 210095 (China) College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 (China)

A sand culture experiment was conducted to determine the effects of different seawater (5% and 10%) treatments on plant growth,inorganic ions,indole alkaloid concentrations and yields of Catharanthus roseus,in an effort to increase the alkaloid yield by artificial *** total fresh and dry weights and tissue K + concentrations decreased,but Na + concentrations increased in the plant roots,stems and leaves of *** under seawater stress as compared to the *** concentrations and yields of vindoline,catharanthine,vinblastine and vincristine increased under seawater *** concentrations and yields of these alkaloids were higher in 5% seawater-treated plants than those in the 10% seawater-treated *** the industrial production,5% seawater treatments could reduce the cost of producing *** the control plants,the highest alkaloid concentrations reached a peak at 100 days after planting,suggesting that plant harvest must be optimized in terms of growth duration.

关键词： indole alkaloid inorganic ions plant growth seawater irrigation seawater stress

Collective synthesis of indole alkaloids based on cascade reactions

在线全文

学校读者我要写书评

暂无评论

Collective synthesis of indole alkaloids based on cascade re...

Enantioselective total synthesis of (+)-vincamine

中国化学会第十二届全国天然有机化学学术会议

作者：秦勇 Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education and Sichuan Engineering Laboratory for Plant-Sourced Drug and Research Center for Drug Industrial Technology West China School of PharmacyState Key Laboratory of BiotherapySichuan University

We have previously reported a series of total syntheses of indole alkaloids based on a highly efficient CRI *** we would like to describe a novel synthetic strategy of using photocatalytic conditions to generate nitrogen-centered radical from aniline-type sulfonamide,which radical could then initiate radical cascade reactions with excellent chemo-,regio-,and *** synthetic strategy has enabled efficient syntheses of 33 monoterpenoid indole alkaloids belonging to four families. Further application of this synthetic strategy to the total synthesis of a various indole alkaloids with diverse skeletons in a concise manner,including(-)-strempeliopine,(-)-terengganensine A,(+)-larutenine,(-)-terengganensine B,(+)-cinchonidine,and(+)-strictamine,is also reported.

关键词： Nitrogen-centered radical Cascade reaction indole alkaloid Collective total synthesis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第4期33卷 2044-2046页

作者： Fanglin Xue Hengmao Liu Rui Wang Dan Zhang Hao Song Xiao-Yu Liu Yong Qin Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

A catalytic asymmetric total synthesis of(+)-vincamine is presented. Key features of the synthesis include a Pd-catalyzed enantioselective decarboxylative allylation to form the C20 quaternary stereogenic center and a... 详细信息

关键词： indole alkaloid Decarboxylative allylation Stereoselective iminium reduction Natural product Total synthesis