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Sox9 is indispensable for testis differentiation in the red-eared slider turtle,a reptile with temperaturedependent sex determination

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Zoological Research 2021年第6期42卷 721-725页

作者： Hang-Bo Hui Ling Xiao Wei Sun Ying-Jie Zhou Hai-Yan Zhang Chu-Tian Ge Institute of Animal Sex and Development Zhejiang Wanli UniversityNingboZhejiang 315100China

SOX9(SRY-related HMG box gene 9)is an essential regulator of male sex determination and testis differentiation in many vertebrate ***,the functional role of Sox9 in testis differentiation has not yet been identified in any reptilian ***,Sox9 knockdown in the red-eared slider turtle(Trachemys scripta)embryos at a male-producing temperature led to complete male-to-female sex reversal,characterized by the formation of an ovary-like structure,disappearance of male marker AMH,and ectopic expression of ovarian regulator FOXL2,as well as a female distribution pattern of germ ***,in-ovo overexpression of Sox9 at a female-producing temperature resulted in partial masculinization of putative female embryos,with the coexistence of AMH and *** study provides the first direct evidence that Sox9 is indispensable for testicular differentiation in a reptilian species,further confirming the conserved role of Sox9 in vertebrate sexual development.

关键词： Sox9 determination indispensable

Metal ion metabolism and osteoporosis:possible implications for pharmaceutical biotechnology and tissue engineering

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Science China(Life Sciences) 2024年第8期67卷 1763-1765页

作者： Huaqiang Tao Qiufei Wang Kai Chen Pengfei Zhu Ye Gu Dechun Geng Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Orthopedics Changshu Hospital Affiliated to Soochow UniversityFirst People’s Hospital of Changshu CityChangshu 215506China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China

Osteoporosis(OP)is a systemic metabolic bone disease characterized by low bone mass,damage to bone microstructure and increased bone *** imbalance of functional coupling between osteoblasts and osteoclasts contributes to the pathological progression of the disease(Rachner et al.,2011).The pathogenesis of OP is precisely controlled by the complex regulatory network of the bone *** elements,although present in small amounts in the body,are essential for their influence on the physiological activities of *** ions act as effective catalysts and have applications in all stages of cell biochemical evolution(Qian et al.,2021).Bone tissue contains various metal elements,and metal ions play indispensable roles in bone metabolism at the molecular and cellular levels(Luo et al.,2023).However,it is important to note that these metal ions can also contribute to the progression of OP by influencing multiple cellular pathways either directly or indirectly.

关键词： metabolism biotechnology indispensable

Integrated Structures and Materials Design of Mechanical Components

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 1-2页

作者： Geng Chen Lele Zhang Christoph Broechmann Chao Chang School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing100044China National International Science and Technology Cooperation Base on Railway Vehicle Operation of Beijing Jiaotong University Beijing100044China Chair and Institute for Materials Applications in Mechanical Engineering RWTH Aachen University52062AachenGermany School of Applied Science Taiyuan University of Science and TechnologyTaiyuan030024China

In recent years,high fidelity numerical models simultaneously reflecting the behaviors of mechanical systems and their underlying materials have gradually become an indispensable part of modern mechanical and production *** different contexts,the attempt to bridge me chanical engineering with materials science and to replace phenomenological models by the physical ones are named either as integrated computational materials engineering(ICME)or integrated structures and materi als design(ISMD).

关键词： replace Structures indispensable

Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A

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Neuroscience Bulletin 2021年第10期37卷 1487-1492页

作者： Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang Department of Rehabilitation The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510600China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510080China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510700China

Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown.

关键词： exercise translational indispensable

Sub-acute toxicity of licorice-sargassum extract in Sprague-Dawley rats:biochemical,histopathological,and pharmacokinetic studies

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Chinese Medical Journal 2022年第7期135卷 872-874页

作者： Xinyue Jing Xian Meng Zhenhui Wu Yongfang Ding Yunru Peng Mingqing Shen Qing Wang Nanjing University of Chinese Medicine NanjingJiangsu 210023China Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjingJiangsu 210023China Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine NanjingJiangsu 210028China Jiangsu Provincial Academy of Traditional Chinese Medicine NanjingJiangsu 210028China College of Nursing Nanjing University of Chinese MedicineNanjingJiangsu 210023China

To the Editor:The"eighteen antagonistic medicaments,"an indispensable component of Oriental Pharmacology,states that sargassum and licorice should not be administered simultaneously.^([1])Researchers have reported that co-administration of licorice and sargassum exerted toxic effects on the heart,liver,and kidney of rats.^([2,3])However,the classic recipe"Hai-Zao-Yu-Hu-Tang,"(containing licorice and sargassum)is currently used,though the safety profile of this medication has not been clearly ***.

关键词： cor simultaneous indispensable

Construction of Powerful Province of Culture:Implication,Logic and Evaluation

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学术界 2010年第10期 255-257页

作者： Song Hong The Theory Department ofAnhui Daily

During the period of the Twelfth Five-year Development Program,cultural construction including the development of cultural industry will become one of the most important strategies in development plan of each province in our *** a popular phenomenon,cultural construction implicates lots of theory *** theoretical questions need to be answered,such as what is the true meaning of the conception of Powerful Province of Culture?What is the logical relationship between each parts of it?What are the standards used to evaluate it?This paper tries to discuss the logical relationship between public cultural service and cultural industry.

关键词： conception goods questions citizen vocational universal creative favorable utility indispensable

Drawing a Conceptual Triangle—Introduction to the Special Theme "Comparing Virtues, Roles, and Duties in Early China and Graeco-Roman Antiquityw

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Frontiers of Philosophy in China 2019年第1期14卷 1-13页

作者： Dennis Schilling School of Philosophy Renmin University of China Beijing 100872 China

"Duty" and "virtue" characterize different, sometimes conflicting theoretical approaches to morality in contemporary philosophy. Duties apply to actions and prescribe what should be done with regard to those moral principles we recognize as essential for doing the right and the good. Virtues refer to traits of human character which enable the moral agent to choose the right aim and the right means to realize what is good. Morality is seen from different perspectives: the former approach narrows the view to the nonnative criteria indispensable for describing an action as morally good or right.

关键词： characterize different principles we recognize criteria indispensable

The Role of PRE-Writing Activities

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The Role of PRE-Writing Activities

作者：李雯菁浙江大学

学位级别：硕士

In the practice of English language teaching, great importance is attached to writing ability of second language learners. There are many difficulties existing in second language writing, and a variety of writing approaches aim to help students solve these problems. The process approach has now attracted most attention.The present research tries to find out the role of pre-writing activities, which is advocated by the process approach. It has been found out that these activities mainly help students develop meaning in their writing although different students reacted in a different way. And they also help students begin their writing more easily.Another finding is the role of the teacher. They are expected to: 1) regard students as writers;2) guide through pre-writing stage;3) integrate receptive skills and productive skills. This research suggests the need for writing instruction by which students can experience writing as a creative process for exploring and communicating meaning.

关键词： writing giving appreciate communicating indispensable linguistics instruction begin sincerely guidance

Non-governmental Organizations As Political Actors in Latin America

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Non-governmental Organizations As Political Actors in Latin ...

作者： Manuel Rodrigo Ballesteros Gonzalez 山东大学

学位级别：硕士

This document aims to explain the importance of NGOs for the different populations of the states that make up Latin America where the arm of their respective governments do not arrive,either due to ignorance or disinterest,something completely necessary benefitting children,young people,adults and the senior members of the society without distinction in terms races or *** should be taken into account by the different governments in order to generate reforms to existing laws or create new policies that seek to direct inclusion of these sectors in the social map which will benefit both these sectors and the government in achieving both of their intentions that seek to promote good governance.　　While it is true that each respective state's government continue to be the main actors in world politics,this does not however make them the only ones;other actors take on strength over time with world politics being the one in charge of recognizing the importance of their actions'contributions.

关键词： political democracy speaking sector governmental objectives indispensable discourse helping director