Metal ion metabolism and osteoporosis:possible implications for pharmaceutical biotechnology and tissue engineering

作     者：Huaqiang Tao Qiufei Wang Kai Chen Pengfei Zhu Ye Gu Dechun Geng 

作者机构：Department of OrthopedicsThe First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of OrthopedicsChangshu Hospital Affiliated to Soochow UniversityFirst People’s Hospital of Changshu CityChangshu 215506China Department of OrthopedicsHai’an People’s HospitalHai’an 226600China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2024年第67卷第8期

页      面：1763-1765页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82072425,82072498,82272567) the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)and the Program of Jiangsu Science and Technology Department(BE2021637) Jiangsu Medical Research Project(ZD2022014) Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(LCZX202003) the Program of Suzhou Health Commission(GSWS2022002) National and Local Engineering Laboratory of New Functional Polymer Materials(SDGC2205) 

主　　题：metabolism biotechnology indispensable 

摘      要：Osteoporosis(OP)is a systemic metabolic bone disease characterized by low bone mass,damage to bone microstructure and increased bone *** imbalance of functional coupling between osteoblasts and osteoclasts contributes to the pathological progression of the disease(Rachner et al.,2011).The pathogenesis of OP is precisely controlled by the complex regulatory network of the bone *** elements,although present in small amounts in the body,are essential for their influence on the physiological activities of *** ions act as effective catalysts and have applications in all stages of cell biochemical evolution(Qian et al.,2021).Bone tissue contains various metal elements,and metal ions play indispensable roles in bone metabolism at the molecular and cellular levels(Luo et al.,2023).However,it is important to note that these metal ions can also contribute to the progression of OP by influencing multiple cellular pathways either directly or indirectly.