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Overview of Recombinant Skin Models and Progress in Their Application in vitro Assessment of Toxicity and Efficacy

China Detergent & Cosmetics 2023年第1期8卷 38-44页

作者： Zhang Bowen Xu Qiufeng GU Wu Zhang Zhichun Dai Yumeng Han Zhiyang Xu Mingkai Wang Yu Key Laboratory of Pollution Ecology and Environment Engineering Chinese Academy of SciencesChina Shenyang Zeer Testing Service Co. Ltd.China

A recombinant skin model is a model in which skin cells are grown in vitro on a bioactive scaffold and provided with adequate nutrition to promote cell proliferation and differentiation to produce a mock skin structure and biological features. The development of recombinant skin models allows for effective and scientifically sound in vitro evaluation tests. This review briefly summarizes the overview of recombinant skin models and the progress of their application in in vitro evaluation which focuses on three aspects: skin irritation, skin corrosivity, and anti-skin aging. Moreover, an outlook on the future development of recombinant skin models is also provided in this review.

关键词： recombinant skin model in vitro evaluation irritation corrosiveness anti-skin aging

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Preparation and evaluation of tamsulosin hydrochloride sustained-release pellets modified by two-layered membrane techniques

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Asian Journal of Pharmaceutical Sciences 2015年第1期10卷 31-39页

作者： Jingmin Wang Yinghua Sun Bo Li Rui Fan Bing Li Tengrui Yin Ling Rong Jin Sun Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China

The aim of the present study was to develop tamsulosin hydrochloride sustained-release pellets using two-layered membrane *** granulator and fluidizedbed coater were employed to prepare drug-loaded pellets and to employ two-layered membrane coating *** prepared pellets were evaluated for physicochemical characterization,subjected to differential scanning calorimetry(DSC)and in vitro release of different *** release models and scanning electron microscopy(SEM)were utilized to analyze the release mechanism of Harnual■ and home-made *** comparing the dissolution profiles,the ratio and coating weight gain of Eudragit■ NE30D and Eudragit■ L30D55 which constitute the inside membrane were identified as 18:1 and 10%-11%.The coating amount of outside membrane containing Eudragit■ L30D55 was determined to be 0.8%.The similarity factors(f_(2))of home-made capsule and commercially available product(Harnual■)were above 50 in different dissolution *** studies confirmed that drug and excipients had good compatibility and SEM photographs showed the similarities and differences of coating surface between Harnual■ and self-made pellets before and after *** to Ritger-Peppas model,the two dosage form had different release mechanism.

关键词： Preparation in vitro evaluation Tamsulosin hydrochloride Sustained-release pellets Drug release mechanism Stability study

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