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Preparation of porous Ta-10%Nb alloy scaffold and its in vitro biocompatibility evaluation using MC3T3-E1 cells

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Transactions of Nonferrous Metals Society of China 2018年第10期28卷 2053-2061页

作者： Jing-lei MIAO Jue LIU Hui-feng WANG Hai-lin YANG Jian-ming RUAN State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Orthopedics The Third Xiangya Hospital of Central South UniversityChangsha 410013China

A highly porous Ta-10%Nb alloy was successfully prepared for tissue engineering via the methods of the sponge impregnation and sintering *** porous Ta-10%Nb alloy offers the capability of processing a pore size of 300-600μm,a porosity of(68.0±0.41)%,and open porosity of(93.5±2.6)%.The alloy also shows desirable mechanical properties similar to those of cancellous bone with the elastic modulus and the comprehensive strength of(2.54±0.5)GPa and(83.43±2.5)MPa,*** morphology of the pores in the porous Ta-Nb alloy shows a good interconnected three-dimension(3D)network open cell *** is also found that the rat MC3T3-E1 cell can well adhere,grow and proliferate on the porous Ta-Nb *** interaction of the porous alloy on cells is attributed to its desirable pore structure,porosity and the great surface *** advanced mechanical and biocompatible properties of the porous alloy indicate that this material has promising potential applications in tissue engineering.

关键词： porous Ta-Nb alloy low elastic modulus pore structure in vitro evaluation

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Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 396-403页

作者： Mina Yan Zhaoguo Zhang Shengmiao Cui Xuefei Zhang Weijing Chu Ming Lei Ke Zeng Yunhui Liao Yihui Deng Chunshun Zhao School of Pharmacy Shenyang Pharmaceutical University School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou Higher Education Mega Center

The aim of the present study was to develop layered double hydroxide(LDH) nanoparticles coated with PEGylated phospholipid membrane. By comparing the size distribution and zeta potential, the weight ratio of LDH to lipid materials which constitute the outside membrane was identified as 2:1. Transmission electron microscopy photographs confirmed the core-shell structure of PEGylated phospholipid membrane coated LDH(PEG-PLDH)nanoparticles, and cell cytotoxicity assay showed their good cell viability on Hela and BALB/C-3 T3 cells over the concentration range from 0.5 to 50 μg/mL.

关键词： in vitro evaluation Layered double hydroxides Phospholipid membrane Preparation Size distribution Zeta potential

Preparation and evaluation of tamsulosin hydrochloride sustained-release pellets modified by two-layered membrane techniques

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Asian Journal of Pharmaceutical Sciences 2015年第1期10卷 31-39页

作者： Jingmin Wang Yinghua Sun Bo Li Rui Fan Bing Li Tengrui Yin Ling Rong Jin Sun Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China

The aim of the present study was to develop tamsulosin hydrochloride sustained-release pellets using two-layered membrane *** granulator and fluidizedbed coater were employed to prepare drug-loaded pellets and to employ two-layered membrane coating *** prepared pellets were evaluated for physicochemical characterization,subjected to differential scanning calorimetry(DSC)and in vitro release of different *** release models and scanning electron microscopy(SEM)were utilized to analyze the release mechanism of Harnual■ and home-made *** comparing the dissolution profiles,the ratio and coating weight gain of Eudragit■ NE30D and Eudragit■ L30D55 which constitute the inside membrane were identified as 18:1 and 10%-11%.The coating amount of outside membrane containing Eudragit■ L30D55 was determined to be 0.8%.The similarity factors(f_(2))of home-made capsule and commercially available product(Harnual■)were above 50 in different dissolution *** studies confirmed that drug and excipients had good compatibility and SEM photographs showed the similarities and differences of coating surface between Harnual■ and self-made pellets before and after *** to Ritger-Peppas model,the two dosage form had different release mechanism.

关键词： Preparation in vitro evaluation Tamsulosin hydrochloride Sustained-release pellets Drug release mechanism Stability study

Overview of Recombinant Skin Models and Progress in Their Application in vitro Assessment of Toxicity and Efficacy

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China Detergent & Cosmetics 2023年第1期8卷 38-44页

作者： Zhang Bowen Xu Qiufeng GU Wu Zhang Zhichun Dai Yumeng Han Zhiyang Xu Mingkai Wang Yu Key Laboratory of Pollution Ecology and Environment Engineering Chinese Academy of SciencesChina Shenyang Zeer Testing Service Co. Ltd.China

A recombinant skin model is a model in which skin cells are grown in vitro on a bioactive scaffold and provided with adequate nutrition to promote cell proliferation and differentiation to produce a mock skin structure and biological features. The development of recombinant skin models allows for effective and scientifically sound in vitro evaluation tests. This review briefly summarizes the overview of recombinant skin models and the progress of their application in in vitro evaluation which focuses on three aspects: skin irritation, skin corrosivity, and anti-skin aging. Moreover, an outlook on the future development of recombinant skin models is also provided in this review.

关键词： recombinant skin model in vitro evaluation irritation corrosiveness anti-skin aging

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