Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles

作     者：Mina Yan Zhaoguo Zhang Shengmiao Cui Xuefei Zhang Weijing Chu Ming Lei Ke Zeng Yunhui Liao Yihui Deng Chunshun Zhao 

作者机构：School of Pharmacy Shenyang Pharmaceutical University School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou Higher Education Mega Center 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学(英文版))

年 卷 期：2016年第11卷第3期

页      面：396-403页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the financial support from the National Natural Science Foundation of China(rant numbers 81302715/H3008 and 81173003/H3008) 

主　　题：Preparation In vitro evaluation Layered double hydroxides Phospholipid membrane Size distribution Zeta potential 

摘      要：The aim of the present study was to develop layered double hydroxide(LDH) nanoparticles coated with PEGylated phospholipid membrane. By comparing the size distribution and zeta potential, the weight ratio of LDH to lipid materials which constitute the outside membrane was identified as 2:1. Transmission electron microscopy photographs confirmed the core-shell structure of PEGylated phospholipid membrane coated LDH(PEG-PLDH)nanoparticles, and cell cytotoxicity assay showed their good cell viability on Hela and BALB/C-3 T3 cells over the concentration range from 0.5 to 50 μg/mL.