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Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with PCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo trials.However,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based implants.Thus,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment modalities.The primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat model.In addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical applications.Compared to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D evaluation.The bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in humerus.In the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy site.Principal component analysis(PCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D scoring.The study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium implants Bone fracture Mineralization Systemic modulation Principal component analysis.

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Immune response differences in degradable and non-degradable alloy implants

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Bioactive Materials 2023年第6期24卷 153-170页

作者： Taravat Khodaei Elizabeth Schmitzer Abhirami P.Suresh Abhinav P.Acharya Biomedical Engineering School of Biological and Health System EngineeringArizona StateUniversityTempeAZ85281USA Biological Design Arizona State UniversityTempeAZ85281USA Chemical Engineering School for the Engineering of MatterTransportand EnergyArizona StateUniversityTempeAZ85281USA Materials Science and Engineering School for the Engineering of MatterTransportand EnergyArizona State UniversityTempeAZ85281USA Center for Immunotherapy Vaccines and VirotherapyArizona State UniversityTempeAZ85281USA

Alloy based implants have made a great impact in the clinic and in preclinical research.Immune responses are one of the major causes of failure of these implants in the clinic.Although the immune responses toward non-degradable alloy implants are well documented,there is a poor understanding of the immune responses against degradable alloy implants.Recently,there have been several reports suggesting that degradable implants may develop substantial immune responses.This phenomenon needs to be further studied in detail to make the case for the degradable implants to be utilized in clinics.Herein,we review these new recent reports suggesting the role of innate and potentially adaptive immune cells in inducing immune responses against degradable implants.First,we discussed immune responses to allergen components of non-degradable implants to give a better overview on differences in the immune response between non-degradable and degradable implants.Furthermore,we also provide potential areas of research that can be undertaken that may shed light on the local and global immune responses that are generated in response to degradable implants.

关键词： alloy utilized implants

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Craniofacial therapy:advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions

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International Journal of Oral Science 2023年第1期15卷 33-49页

作者： Karan Gulati Chengye Ding Tianqi Guo Houzuo Guo Huajie Yu Yan Liu The University of Queensland School of DentistryHerstonQLDAustralia Laboratory of Biomimetic Nanomaterials Department of OrthodonticsPeking University School and Hospital of StomatologyBeijingChina National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials BeijingChina Department of Oral Implantology Peking University School and Hospital of StomatologyBeijingChina Fourth Clinical Division Peking University School and Hospital of StomatologyBeijingChina

Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects,including traumas and tumours.Critical to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma conditions.Further,race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the implant.In this pioneering review,we compare the therapeutic efficacy of nano-engineered titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption,soft-tissue integration,bacterial infection and cancers/tumours.We present the various strategies to engineer titanium-based craniofacial implants in the macro-,micro-and nano-scales,using topographical,chemical,electrochemical,biological and therapeutic modifications.A particular focus is electrochemically anodised titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic release.Next,we review the clinical translation challenges associated with such implants.This review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants.

关键词： implants titanium local

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Advancing dental implants:Bioactive and therapeutic modifications of zirconia

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Bioactive Materials 2022年第7期7卷 161-178页

作者： Divya Chopra Anjana Jayasree Tianqi Guo Karan Gulati Saso Ivanovski The University of Queensland School of DentistryHerston QLD4006Australia

Zirconium-based implants have gained popularity in the dental implant field owing to their corrosion resistance and biocompatibility,attributed to the formation of a native zirconia(ZrO_(2))film.However,enhanced bioactivity and local therapy from such implants are desirable to enable the earlier establishment and improved long-term maintenance of implant integration,especially in compromised patient conditions.As a result,surface modification of zirconium-based implants have been performed using various physical,chemical and biological techniques at the macro-,micro-,and nano-scales.In this extensive review,we discuss and detail the development of Zr implants covering the spectrum from past and present advancements to future perspectives,arriving at the next generation of highly bioactive and therapeutic nano-engineered Zr-based implants.The review provides in-depth knowledge of the bioactive/therapeutic value of surface modification of Zr implants in dental implant applications focusing on clinical translation.

关键词： Zirconium Zirconia implants Surface modification Osseointegration Bioactivity Local therapy

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NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

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Journal of Materials Science & Technology 2022年第19期114卷 120-130页

作者： M.M.Costa A.Miranda F.Bartolomeu O.Carvalho S.Matos G.Miranda F.S.Silva Center for MicroElectroMechanical Systems(CMEMS-UMinho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for os-seointegration.This work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based designs.Their performance was evaluated in vivo through implantation in Sprague Dawley rats’femur,being then analyzed after 4 and 12 weeks of implantation.Push-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured NiTi.Histology showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had developed.Con-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).Moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212%when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

关键词： NiTi Laser surface texturing In vivo studies Osseointegration implants

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Evaluation of Novel Chitosan Based Composites Coating on Wettability for Pure Titanium implants

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Journal of Renewable Materials 2023年第4期11卷 1601-1612页

作者： Qahtan A.Hamad Hanaa A.Al-Kaisy Mohanad N.Al-Shroofy Noor K.Faheed Materials Engineering Department University of TechnologyBaghdadIraq Petroleum Engineering Department University of MisanAmaraIraq

This work aims to prepare chitosan(CS)-based coated layers,CS(10 wt%nanosilver/90 wt%CS,10 wt%biotin/90 wt%CS,and 5 wt%nanosilver–5 wt%biotin)/90 wt%CS coatings are prepared,onto pure Ti substrate.The surface morphology of the novel CS composite coating was studied using field emission scanning electron microscopy,atomic force microscopy(AFM),Fourier transforms infrared(FTIR)and wettability test.Results show that the addition of(biotin,nanosilver)5 Vol.%improves the properties of composite materials.Using different particles’scale size aid in improving the combinations in the alginate,producing a dual effect on film properties.Coating surface roughness decreased in the chitosan-based biocomposite with preferable homogeneity and crack-free coating layers,as confirmed by AFM.An increase in surface roughness ensured substitution,which enhanced the surface structures.The high wettability of the CS-based coating layers was due to the presence of nanoparticles,and the composite coatings with CS,nanosilver,or biotin had excellent wettability because of the good hydrophilic nature of the CS matrix combined with reinforced particles.The FTIR results showed that peaks of the blending of CS plus nanoparticles,CS plus biotin,or CS plus nanosilver plus biotin were excellent matching with no changes in the structure of the matrix.

关键词： Nano silver biotin chitosan coating bio-composite implants titanium

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Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants

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Bioactive Materials 2017年第1期2卷 44-50页

作者： Tingting Wang Zhengyang Weng Xiangmei Liu Kelvin W.K.Yeung Haobo Pan Shuilin Wu Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina Division of Spine Surgery Department of Orthopaedics&TraumatologyLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Bacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants;thus,surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic implants.In this work,a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid)(PLGA)and titania nanotubes(TNTs)has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug release.By varying the size of the TNTs and the thickness of the polymer film,the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment time.The size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid coatings.In this work,TNTs with an average size of 80 nm can achieve the largest loading dose.Depending on the polymer thickness,significant improvement in the drug release characteristics is attained,for instance,reduced burst release(from 84%to 27%)and overall release time extended from 5 to over 40 days.In addition,the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier stage.Therefore,this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials.

关键词： Antibacterial Biocompatibility Coating Drug delivery implants

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Strategies for creating living, additively manufactured, open-cellular metal and alloy implants by promoting osseointegration,osteoinduction and vascularization: An overview

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Journal of Materials Science & Technology 2019年第2期35卷 231-241页

作者： Lawrence E.Murr Department of Metallurgical Materials and Biomedical Engineering The University of Texas at El Paso W.M.Keck Center for 3D Innovation The University of Texas at El Paso

Additive manufacturing of porous, open-cellular metal or alloy implants, fabricated by laser or electron beam melting of a powder bed, is briefly reviewed in relation to optimizing biomechanical compatibility by assuring elastic(Young's) modulus matching of proximate bone, along with corresponding pore sizes assuring osseointegration and vasculature development and migration. In addition, associated, requisite compressive and fatigue strengths for such implants are described. Strategies for optimizing osteoblast(bone cell) development and osteoinduction as well as vascularization of tissue in 3 D scaffolds and tissue engineering constructs for bone repair are reviewed in relation to the biology of osteogenesis and neovascularization in bone, and the role of associated growth factors, bone morphogenic proteins, signaling molecules and the like. Prospects for infusing hydrogel/collagen matrices containing these cellular and protein components or surgically extracted intramedullary(bone marrow) concentrate/aspirate containing these biological and cell components into porous implants are discussed, as strategies for creating living implants, which over the long term would act as metal or alloy scaffolds.

关键词： Additive manufacturing Open cellular metal and alloy implants Electron beam melting Living implant strategies Vascularization Osseointegration Osteoinduction

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Quality of life of parents and siblings of children with cochlear implants

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Journal of Otology 2019年第1期14卷 17-21页

作者： Cila Umat Nor Haniza Abdul Wahat Sakinah Che Ross Bee See Goh Audiology Program Center for Rehabilitation & Special Needs Faculty of Health Sciences Universiti Kebangsaan Malaysia (UKM) Department of Otorhinolaryngology-Head & Neck Surgery Faculty of Medicine Universiti Kebangsaan Malaysia Medical Centre

Objectives: This study examined the quality of life(QoL) of the parents and siblings of hearing-impaired children with cochlear implants(CIs).Design: This is a cross-sectional, questionnaire-based study. The questionnaire consists of three sub-domains-interaction, emotional well-being and support for the hearing-impaired child and the overall QoL – and two open-ended questions for participants to provide comments and suggestions to enhance their family's QoL. A total of 63 questionnaires were e-mailed or mailed to families who met the inclusion criteria.Setting: The study was conducted under the Center for Rehabilitation & Special Needs, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur.Participants: A total of 79 parents and 23 siblings from 44 families of children with CI participated in this study.Main outcome measures: The mean score for each of the sub-domain and the overall QoL for both subject groups were computed. The answers for the open-ended questions were listed and organized into themes.Results: There were significant correlations between the overall QoL score and each of the test domains for the parents' group(p < 0.01). For the siblings' group, only the interaction and support domains were significant.Interaction was the main sub-domain affecting the parents' QoL but for siblings, this could not be determined. A total of 60% of the pooled comments were classified as ‘concerns'. As for the suggestions, 38.7% requested some form of support, mainly financial(41.7%).Conclusions: Families with hearing impaired children with CI have numerous concerns that need to be addressed, even though, on average, they were satisfied with their overall QoL.

关键词： Quality of life(QoL) Cochlear implants Families Parents Siblings

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Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 586-590页

作者： Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang Department of Digestive System Affiliated Hospital of Hainan Medical College

Objective: To study the influence of cisplatin implants on transplantation tumor growth and the expression of tissue kallikrein-7(KLK7) and E-cadherin(E-cad) in tumor-bearing mice with gastric cancer. Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into model control group(Group A), tail intravenous injection of cisplatin group(Group B), intratumor injection of cisplatin group(Group C) and cisplatin implants treatment group(Group D). After the drugs intervening, the weight and volume of transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and KLK7 and E-cad contents in transplanted tumor tissue were examined. Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of transplantation tumors of tumorbearing mice in four groups were different(Group A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue and serum of tumor-bearing mice in four groups were different(Group A > Group B > Group C > Group D in KLK-7) and(Group A implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric

关键词： Gastric cancer Cisplatin implants Tissue kallikrein-7 E-cadherin

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