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Choukroun's PRF在种植临床的应用

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中国口腔种植学杂志 2009年第2期14卷 12-13页

作者：周延民吉林大学口腔医院

Choukroun富血小板纤维蛋白(Choukroun PRF)被誉为新一代血小板浓缩制品.其分子结构类似天然血凝块,为组织细胞提供迁移、增殖及分化的场所,其中滞纳的细胞因子可对修复过程进行调控及免疫调节.我种植中心将其独立及联合人工材料应用于2... 详细信息

Choukroun富血小板纤维蛋白(Choukroun PRF)被誉为新一代血小板浓缩制品.其分子结构类似天然血凝块,为组织细胞提供迁移、增殖及分化的场所,其中滞纳的细胞因子可对修复过程进行调控及免疫调节.我种植中心将其独立及联合人工材料应用于20余例临床骨缺损及骨量不足的患者.现择其3例分述如下.例1:男患,30岁,11桩核冠修复后牙根劈裂.X-ray示:根尖略见阴影.术中见植体与拔牙窝上部间有较大缺损隙.制备PRF,充填于缺隙处.术后1.5月及3月拍摄X-ray片见缺隙显著缩小,牙槽嵴顶位置无显著变化.例2:女患,20岁,龋坏致36牙冠缺损,底穿.X-ray示:36根分叉处略见阴影.术中见植体与拔牙窝近远中均有较大缺隙.拔牙创周粘膜无法拉拢缝合.于缺隙处充填PRF.术后5日见敞开之创口为粘膜覆盖,血运良好.例3:女患,30岁,22根切术失败后拔除患牙.X-ray示:22相对应牙槽骨见烧瓶底样缺损.植骨术中见:21与23间见凹坑状缺损.颏部取骨块植入缺损区,边缘置PRF.术后复诊可见骨块边缘与周围骨的界限逐渐消失,未见明显吸收.ChoukrounPRF可被认为是一种自体移植物,具有临床推广的潜力,我种植中心应用后发现其可不同程度促进组织愈合.但相关临床观察仍需深入.

关键词：缺隙牙槽嵴顶骨量不足桩核冠修复 implant 种植中心拔牙窝 suffered 牙冠缺损 mucosa

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ISQ值与种植体脱落的相关性的临床研究

浙江创伤外科 2014年第2期19卷 183-185页

作者：于国跃浙江省浦江口腔医院浦江322200

目的探讨ISQ值与种植体脱落的相关性。方法严格按照随机化的原则选择2011年5月至2013年5月,于本院就诊的105例牙列缺损患者,共植入148枚非潜入式NobelReplace种植体,并在术后1、3、6、8、12周对其进行稳定性的共振频率分析(RFA)。结果... 详细信息

目的探讨ISQ值与种植体脱落的相关性。方法严格按照随机化的原则选择2011年5月至2013年5月,于本院就诊的105例牙列缺损患者,共植入148枚非潜入式NobelReplace种植体,并在术后1、3、6、8、12周对其进行稳定性的共振频率分析(RFA)。结果根据初期ISQ值是否小于等于50分为低初始值组(ISQ≤50)和高初始值组(ISQ>50),随访发现,低初始值组总脱落率为26.67%,高初始值组总脱落率为1.28%,经卡方分析,χ2=10.85,P<0.01,两组总脱落率差异有统计学意义;高初始值后期有小幅下降,若持续下降,则种植易失败;低初始值后期不断升高,否则种植易失败。结论 ISQ为评价种植体初期稳定性的客观指标,Osstell ISQ能良好评价和监测种植体稳定性,值得在临床上进一步推广。

关键词： ISQ(种植体初期稳定系数) NobelReplace种植体共振频率分析(RFA) implant stability quotient (ISQ) Resonance frequency analysis (RFA)

Effects of Energetic ^(12)C Ions on Anticancer Drug VP_(16)

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IMP & HIRFL Annual Report 2001年第1期 81-81页

作者： Xie Hongmei, Wei Zengquan, Hao Jifang and Tian Xuan College of Chemistry and Chemical Engineering, Lanzhou University.

55 MeV/u ^(12)C^(6+) ions were used to implant into one of the podophyllotoxin derivatives — VP_(16). In order to overcome its disadvantage in clinical application, energy transfer and mass deposition of the heavy ions were used to modify its molecular component and structure so that water-soluble can be improved, therapeutic effect was increased and toxicity was reduced~[1]. After experimental samples were implanted by the ions,

关键词： implant disadvantage overcome toxicity modify restricted instance ultraviolet irradiated dimer

STUDIES OF A BIODEGRADBLE DELIVERY CAPSULES (CAPROF)CONTAINING LEVONORGESTREL (LNG):IN VIVO DRUG RELEASE EVALUATION

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Chinese Journal of Biomedical Engineering(English Edition) 1993年第3期2卷 114-114页

作者： P.Y.Wang C.X.Song X.M.Cui H.L.Shi R.W.Shi & L.Wu Institute of Biomedical Engineering,CAMS,Tianjin 300192,China

The paper describes drug release evaluation of a biodegradable long-acting con-traceptive Capsule (CaproF) containing levonorgestrel (LNG)in vivo.Poly(E-Capro-lactone) (PCL) biodegradable material,suitable for many medical application,wasused in this study.It was extruded into tubes.The tubes were then cut and loadedwith LNG powder before melting-sealed on both ends to get drug capsules.This sub-dernal implant has been found to be highly effective in animal experiments.Two ad-

关键词： biodegradable lactone implant melting sealed LNG capsules acting vantage lease

AB022.Biosynthetic implants for corneal regeneration in patients at high risk of rejecting donor transplantation

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Annals of Eye Science 2019年第1期 197-197页

作者： May Griffith M.Mirazul Islam Oleksiy Buznyk Fiona Simpson Per Fagerholm Keith Meek Virender Sangwan Department of Ophthalmology and Institute of Biomedical Engineering University of Montreal and Maisonneuve-Rosemont Hospital and CHUM Research CentresMontrealQCCanada Department of Clinical and Experimental Medicine Linköping UniversityLinköpingSweden Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary Harvard Medical SchoolBostonMAUSA Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine OdessaUkraine School of Optometry and Vision Sciences College of Biomedical and Life Sciences and Cardiff Institute for Tissue Engineering and Repair(CITER)Cardiff UniversityCardiffUK Tej Kohli Cornea Institute LV Prasad Eye InstituteHyderabadIndia Dr.Schroff Charity Eye Hospital New DehliIndia

Background:Patients with inflammation or severe corneal pathology are often at high risk of rejecting the human donor corneas that they receive during transplantation.Our goal was to determine whether cell-free implants incorporating phosphorylcholine-based polymer,2-methacryloyloxyethyl phosphorylcholine(MPC),which has inflammation suppressing properties,can support repair and regeneration of ulcerated,high-risk corneas.Methods:Interpenetrating networks of recombinant human collagen and MPC(RHC-MPC)were fabricated into corneal implants in a certified and monitored cleanroom.An open-label,first-in-human observational study was conducted following ISO 14971 and 14155:2011,the Declaration of Helsinki and relevant laws of Ukraine and India,after respective ethical approval and trial registration.Seven unilaterally blind patients,aged 36 to 76 years old,diagnosed with conditions putting them at high risk of rejecting conventional corneal transplantation,and capable of providing informed written consent were grafted and followed up for an average of two years.However,RHC like native collagen is a large macromolecule and difficult to process and is non-customisable.Hence,small,customisable analogs to collagen comprising collagen-like peptides(CLP)conjugated to polyethylene glycol(PEG)were developed.These CLP-PEG analogs like RHC were combined with MPC into implants and tested in mini-pig models with alkali burned corneas,a high-risk condition.Results:One patient had an unrelated infection that necessitated re-grafting and was excluded from the study.The RHC-MPC implants in the remaining six patients were stably integrated throughout the entire observational period.There was regeneration of the cornea epithelium and stroma.Significant vision improvement was observed in in patients with damaged corneas due to infection.By two weeks post-operation,RHC-MPC implanted corneas of patients with active ulcers were free from the symptoms of pain,irritation and photophobia.Over the two-year follow-up period,sensitivity to touch i

关键词： Cornea inflammation implant clinical trial pigs

AB085.E-beam sterilization of recombinant human collagen-phosphorylcholine corneal implants for transplantation

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Annals of Eye Science 2018年第1期 491-491页

作者： Fiona Simpson Joel Edin Mohammed Mirazol Islam Oleksiy Buznyk Monika Ljunggren Kozak Aneta Liszka Kim Merrett Håkan Per Fagerholm Gustafsson May Griffith Maisonneuve-Rosemont Hospital Research Centre and Department of Ophthalmology University of MontrealMontrealQuébecCanada

Background:The sterilization of corneal implants composed of carbodiimide crosslinked recombinant human collagen type III(RHCIII)and phosphorylcholine polymers(RHCIII-MPC)is constrained by the biochemical properties of RHCIII.Early human trials used 1%chloroform in 0.1 M phosphate buffered saline(C-PBS),but require a stringent wash procedure with antibiotics to remove the chloroform.Irradiation with gamma or electron-beam(e-beam)allows a chemical-free sterilization method,but may result in crosslinking or denaturation.Here,electron-beam irradiation is evaluated as a sterilization method for RHCIII-MPC implants.Methods:Dose-finding study:RHCIII-MPC were cast in round,350µm thick,12 mm diameter molds for corneal implants and 0.5 mm thick dumbbell-shaped molds for mechanical testing.The hydrogels received an irradiation dose of 17,19,or 21 kGy and unirradiated controls were stored in C-PBS,n=3 per group.The hydrogels were tested for sterility and endotoxin,optical and mechanical properties,biodegradation,free radicals,and cell compatibility.Clinical evaluation in rabbits:RHCIII-MPC implants were e-beamed at 17 kGy or kept in C-PBS.One implant from each group was implanted into the right cornea of each rabbit by deep anterior lamellar keratoplasty,n=4 animals per group.Animals underwent preoperative and 6-month post-operative in vivo confocal microscopy(IVCM)to check nerve count and ingrowth of keratocytes.Corneal grafts and controls were assessed via histology and immunohistochemistry.Results:Dose finding study:hydrogels were sterile at all irradiation doses with no evidence of free radicals.There were no significant differences in optical or mechanical properties between the treatment groups and controls.All hydrogels supported cell growth.The 19 and 21 kGy implants had high collagenase degradation for 21 hours until they stabilized,whereas the 17 kGy and C-PBS implants had gradual degradation until 48 hours.Clinical results:the rabbits did not experience post-surgical inflammatory reactions and full epithelial cov

关键词： Cornea collagen tissue scaffolds implant regenerative medicine

Effects of tobacco extract on adhesion and proliferation of human osteoblasts on titanium implants

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外科研究与新技术 2011年第4期 271-271页

作者：郑月涵 Plast Surg Hosp Chin Acad Med SciPeking Union Med Col

Objective To investigate effect of smokingless tobacco extract ( ST) on number,adhesion,morphology and proliferation of human osteoblasts on titanium implants in vitro. Methods Human osteoblasts on titanium implants w... 详细信息

关键词： titanium tobacco morphologic cultured implant attachment alkaline