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Near infra-red light treatment of Alzheimer's disease

Journal of Innovative Optical Health Sciences 2018年第1期11卷 57-64页

作者： Mengmeng Han Qiyan Wang Xue Wang Yuhui Zeng Yong Huang Qingqiang Meng Jun Zhang Xunbin Wei Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University 1954 Huashan Road Shanghai 200030P.R.China Zhejiang BrainHealth Medical Technology Co.Ltd 332 Wangjiang Road Hangzhou 310002P.R.China Department of Neurosurgery General Hospital of PLA 28 Fuxing Road Beijing 100853 P.R.China

Alzheimers disease(AD)is a chronic neurodegenerative *** symptoms include memoryand spatial learning dificulties,language disorders,and loss of motivation,which get worse overtime,eventually ending in *** ffective treatments are available for AD,*** only attenuate symptoms temporarily and are associated with severe side ***-red(NIR)light has been studied for a long *** investigated the effect of NIR on ADusing a transgenic mouse model,which was obtained by co-injecting two vectors carrying ADmutations in amyloid precursor protein(APP)and presenilin-i(PSEN1)into C57BL/6J *** irradiation equipment consisted of an accommodating box and an LED *** wave-length of NIR light emitted from LED was between 1040 nm and 1090 *** power densitydelivered at the level of the mice was approximately 15 mW/cm^(2),Firstly,we treated the micewith NIR for 40 days,Then,the irradiation was suspended for 28 ***,another 15 daystreatment was brought to *** conducted Morris water maze and immunofluorescenceanalysis to evaluate the effects of *** analysis was based on mea-suring the quantity of plaques in mouse brain slices,Our results show that NIR light improvesmemory and spatial learning ability and reduces plaques *** light represents apotential treatment for AD.

关键词： Alzheimer's disease near infra-red light transgenic mouse model Moris water maze immunofluorescence analysis

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Quantum Dots as Fluorescent Labels for Detection of Heat Shock Protein in Tumor Tissue Using Laser Scanning Confocal Microscope

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Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 257-259页

作者：杨欢张杰 Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Urology Renmin hospital of Wuhan University

A new Quantum Dots（Qdots） nanocrystal composed of semiconductor core and zinc sulfide shell, and its feasibility as labels in immunofluorescence analysis for the imaging of tumor biomarkers by laser scanning confocal microscope（LSCM） was investigated. Qdots taged by mercaptoacetic acid were conjugated with second antibody, then imaging differences of Heat Shock Proteins 70（HSP70） in renal carcinoma tissure sections with immunofluorescence analysis method using Qdots bioconjugates and conventional organic dye FITC were observed by LSCM to assess the brightness and opticalstability of Qdots. The experimental results showed Qdots bioconjugates achieved the better results in demonstrating HSP70 with more brighter color and more clear picture than FITC labels. Moreover, the label signals of Qdots did not fade clearly after continued exposure to a 488 nm laser for 1 h. The Qdots bioconjugates have good feasibility in immunofluorescence analysis for the bioimaging by LSCM.

关键词： quantum dots immunofluorescence analysis bioimaging laser scanning confocal microscope

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