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Active DNA demethylation regulates MAMP-triggered immune priming in Arabidopsis

Journal of Genetics and Genomics 2022年第8期49卷 796-809页

作者： Mengling Huang Ying Zhang Ying Wang Jiatao Xie Jiasen Cheng Yanping Fu Daohong Jiang Xiao Yu Bo Li State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanHubei 430070China The Provincial Key Lab of Plant Pathology of Hubei Province College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Plants recognize microbe-associated molecular patterns(MAMPs)to activate immune responses and defense priming to defend against pathogen *** regulation of gene expression is crucial for plant immunity and is mediated by multiple factors,including DNA ***,it remains unknown whether and how DNA demethylation contributes to immune responses in MAMPtriggered ***,we report that active DNA demethylation is required for MAMP-triggered immunity to bacterial *** rdd-2 triple mutant carrying mutations in ROS1,DML2,and DML3 that encode DNA glycosylases,which are key DNA demethylation enzymes,exhibits compromised immune responses triggered by the MAMPs fig22 and ***-wide methylome analysis reveals that fig22 induces rapid and specific DNA demethylation in an RDD-dependent *** expression levels of salicylic acid signaling-related and phytoalexin biosynthesis-related genes are tightly associated with the fig22-induced promoter *** compromised accumulation of priming compounds and antimicrobial metabolites ultimately leads to a defense priming defect in the rdd-2 *** results reveal the critical role of active DNA demethylation in the MAMP-triggered immune response and provide unique insight into the molecular mechanism of fig22-modulated DNA demethylation.

关键词： Pattern-triggered immunity immune priming Defense gene expression DNA demethylation immune signal transduction

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immune priming Induced by Heat-inactivated White Spot Syndrome Virus (WSSV) in Fenneropenaeus chinensis Cultured at Different Temperature

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Animal Husbandry and Feed Science 2017年第6期9卷 384-389,412页

作者： Cao Jiawang Kong Jie Luo Kun Luan Sheng Cao Baoxiang Shi Xiaoli Lu Xia Meng Xianhong Key Laboratory for Sustainable Utilization of Marine Fisheries Resources Ministry of AgricultureYellow Sea Fisheries Research InstituteChinese Academy of Fishery Sciences Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology

[ Objective] This study was designed to explore whether heat-inactivated white spot syndrome virus （ WSSV ） could induce immune priming in Fenneropenaeus chinensis. [Method] Shrimps cultured at 15 （group E15℃ ）, 23 （group E23℃ ）, 28 （group E28℃ ） and 32 （group E32℃ ）℃ were fed for six successive days with the meat of WSSV-infected shrimps, which had been treated at 60℃ for 1 h. Meanwhile, the shrimps of positive control were fed with a diet containing active WSSV at 23℃ （ group C23℃ ）, and the shrimps of negative control were fed with commercial compound feed only at 23℃ （ group CF23℃ ）. On Day 13 of the experiment, the survivors were re-challenged with active WSSV, and then the survival time, survival rate, mortality rate and viral load in each group were measured. The results showed that no death occurred among the shrimps fed with a diet containing heat-inactivated WSSV before the secondary challenge, while all the shrimps fed with a diet containing active WSSV （ group CF23℃ ） died, suggesting that WSSV was completely inactivated by treatment at 60℃ for 1 h. On day 19 of the experiment, the survival rate in groups E15℃ , E23℃, E28℃, E32℃ and CF23℃ was 80.41% , 33.29%, 8.47% , 16.43% and 8.89%, respectively. There was an extremely significant difference in survival rate between group E15℃ and other groups （ P 〈 0.01 ）, a significant difference in survival rate between group E23℃ and CF23℃ , E28℃, E32℃ （P 〈 0. 05）, and no significant difference in survival rate between groups E28℃ and E32℃ （ P 〉 0. 05 ）. RT-qPCR revealed WSSV replicated most rapidly at 28℃ after the secondary challenge, while high （32℃） and low （ 15℃ ） temperature inhibited the multiplication of WSSV. In summary, heat-inactivated WSSV can induce immune priming response and provide some protection to shrimps against WSSV infection. The multiplication rate of WSSV is closely related to water temperature.

关键词： immune priming Heat-inactivated Survival rate Absolute quantitation WSSV

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Neutrophil programming dynamics and its disease relevance

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Science China(Life Sciences) 2017年第11期60卷 1168-1177页

作者： Taojing Ran Shuo Geng Liwu Li Department of Biological Sciences Virginia Polytechnic Institute and State UniversityBlacksburg VA24061USA Guangdong Provincial Key Laboratory of Gastroenterotogy Department of GastroenterologyNanfang HospitalSouthern Medicat UniversityGuangzhou 510515China

Neutrophils are traditionally considered as first responders to infection and provide antimicrobial host defense. However, recent advances indicate that neutrophils are also critically involved in the modulation of host immune environments by dynamically adopting distinct functional states. Functionally diverse neutrophil subsets are increasingly recognized as critical components mediating host pathophysiology. Despite its emerging significance, molecular mechanisms as well as functional relevance of dynamically programmed neutrophils remain to be better defined. The increasing complexity of neutrophil functions may require integrative studies that address programming dynamics of neutrophils and their pathophysiological relevance. This review aims to provide an update on the emerging topics of neutrophil programming dynamics as well as their functional relevance in diseases.

关键词： programming dynamics immune priming inflammatory diseases

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