检索结果-南通市图书馆

检索条件"主题词=immune evaluation"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice

Immunization with plasmid DNA expressing Heat Shock Protein ...

引用

第十一届全国寄生虫学青年工作者学术研讨会

作者： LI Zhong-Yuan LU Jing ZHANG Nian-Zhang Hany M.Elsheikha HOU Jun-Ling GUO Hai-Ting ZHU Xing-Quan College of Animal Science and Technology Anhui Agricultural University State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences Faculty of Medicine and Health Sciences School of Veterinary Medicine and ScienceUniversity of NottinghamSutton Bonington Campus College of Biological Science and Technology Heilongjiang Bayi Agricultural University

Objective Toxoplasma gondii causes one of the most common protozoal diseases of humans and animals *** the aim of designing an effective vaccine against *** infection,we have examined the immunogenicity of a DNA vaccine expressing heat shock protein 40(HSP40) against challenge with ***(type I RH and type II Pru) strains in Kunming *** The plasmid p VAX1-HSP40 was constructed and used to immunize mice by intramuscular injection for three sequential immunizations with two-week intervals,and the immune responses including specific antibodies,lymphocyte proliferation,cytokines and T lymphocyte subclasses,the survival times of RH-infected mice and the number of cysts in brains of Pru-infected ones were *** This immunization regimen significantly reduced parasite cyst burden in p VAX1-HSP40-immunized mice(1871.9 ± 142.3) compared with control mouse groups immunized with p VAX1(3479.2 ± 204.4),phosphate buffered saline(3024.4 ± 212.8),or left untreated(3275.0 ± 179.8) as healthy controls(P immune responses and achieved a significant reduction in the number of brain cysts in Pru-infected mice,and thus can be tested in future immunization studies along with plasmids containing other immunogenic proteins as a cocktail vaccine to fully abolish chronic toxoplasmosis.

关键词： Toxoplasma gondii HSP40 DNA vaccine chronic infection immune evaluation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：