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Synthesis and pharmacological activity evaluation of curcumin derivatives

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Chinese Chemical Letters 2016年第7期27卷 1067-1072页

作者： Jaggi Lal Sushil K.Gupta D.Thavaselvam Dau D.Agarwal School of Studies in Chemistry Jiwaji University Department of Chemistry Dr. K.N. Modi University Microbiology Division Defence Research Development Establishment

Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation.The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent.All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity.Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.

关键词： Curcumin dihydropyrimidinones/thiones/ imines Microwave irradiations Antioxidant capacity Anti-inflammatory activity

Regio-and Diastereoselective Access to 4-Imidazolidinones via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic imines with α-Halo Hydroxamates

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Regio-and Diastereoselective Access to 4-Imidazolidinones vi...

Palladium-or Copper-Catalyzed Aerobic Oxidative Synthesis of imines from Alcohols and Amines under Ambient Conditions

中国化学会·第十六届全国有机合成化学学术研讨会

作者： Jing Zhou Ya-Li Qu 陈亚静 School of Pharmaceutical Sciences Zhengzhou University 郑州大学

An efficient regio-and diastereoselective cyclization of sulfamate-derived cyclic imines with unsubstituted or mono substituted α-halo hydroxamates is developed under mild conditions.This reaction proceeds smoothly under transition-metal free conditions via a domino aza-Mannich addition/intramolecular nucleophilic substitution sequence,providing a convenient route to access 2-monosubstituted and 2,5-disubstituted 4-imidazolidinones.Notably,the products were obtained with single trans-isomers in moderate to excellent yields.

关键词： 4-imidazolidinones imines α-halo hydroxamates [3+2] cyclization

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Palladium-or Copper-Catalyzed Aerobic Oxidative Synthesis of...

Natural Acid Catalyzed Synthesis of Schiff under Solvent-Free Condition: As a Green Approach

中国化学会第28届学术年会

作者： Haiwen Tian,Lan Jiang,Xiaochun Yu and Qing Xu* College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou 325035

＜正＞imines are a class of nitrogen compounds of high significance in chemistry.For the high reactivity of the C=N double bond,they are both important nitrogen sources and key intermediates in various types of transformations. Therefore,synthesis and applications of imines are essentially the ever-appealing topics in chemistry.However, challenges still remain in the academic researches. Despite other progresses for imine synthesis,traditional condensation of aldehydes or ketones with amines is most often the method of choice.1 Since aldehydes and

关键词： imines Alcohols Amines Aerobic Oxidative Reaction Pd or Cu catalysis

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International Journal of Organic Chemistry 2012年第2期2卷 166-171页

作者： Suresh Patil S. D. Jadhav M. B. Deshmukh U. P. Patil Organic Research Laboratory PG Department of Chemistry PDVP College Tasgaon India

The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that the paper has been submitted to other journals at the same time. The scientific community takes a very strong view on this matter, and the International Journal of Organic Chemistry treats all unethical behavior seriously. This paper published in Vol. 2 No.2 166-171, 2012, has been removed from this site.

关键词： Schiff Base imines Lemon Juice Natural Acid

Synthesis and <i>in Vitro</i>Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

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International Journal of Organic Chemistry 2013年第1期3卷 37-41页

作者： Hanan Sekkak El Mostapha Rakib Medaghri-Alaoui Abdelouahid Abderrafia Hafid Abdelghani El Malki Laboratoire de Chimie Organique et Analytique Faculté des Sciences et Techniques Université Sultan Moulay Slimane Béni-MellalMorocco

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.

关键词： Nitrile imines Cycloaddition Pyrazoles Cytotoxic Activity

One-Pot Three-Component Synthesis of N-Arylmethyl-4-(7-cyclohepta-1,3,5-trienyl)anilines

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International Journal of Organic Chemistry 2013年第2期3卷 148-150页

作者： Lidia P. Yunnikova Tatiana A. Akentieva Tatiana V. Makhova Perm State Agricultural Academy Perm Russia

We report a one-pot three-component synthesis of N-arylmethyl-4-(7-cyclohepta-1,3,5-trienyl)anilines by using various aromatic imines, tropylium tetrafluoroborate, and sodium tetrahydroborate in the presence of imidaz... 详细信息

关键词： imines Tropylium Tetrafluoroborate Sodium Tetrahydroborate N-Arylmethyl-4-(7-cyclohepta-1 3 5-trienyl)anilines

抗衡阴离子促进的手性二胺钌配合物催化亚胺的不对称氢化反应研究（英文）

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抗衡阴离子促进的手性二胺钌配合物催化亚胺的不对称氢化反应研究...