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Fe-porphyrin:A redox-related biosensor of hydrogen molecule

Nano Research 2023年第2期16卷 2020-2025页

作者： Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He Center of hydrogen Science School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China School of Biomedical Engineering Health Science CenterShenzhen University1066 Xueyuan RoadShenzhen 518060China

hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so ***,we originally reveal that Fe-porphyrin is a H_(2)-targeted *** have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of *** discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials.

关键词： hydrogen molecule molecular mechanism molecular target hydrogen medicine porphyrin catalysis carbon monoxide

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hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1329-1339页

作者： Ryo Yamamoto Sayuri Suzuki Koichiro Homma Shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 1608582Japan Division of Endocrinology Metabolism and NephrologyDepartment of Internal MedicineKeio University School of MedicineTokyo 1608582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 1608582Japan

BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after *** gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen species in various animal and clinical *** examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3%hydrogen *** To clarify the treatment effects and target cells of hydrogen gas for mesenteric *** Three rat groups underwent 60-min mesenteric artery occlusion(ischemia),60-min reperfusion following 60-min occlusion(reperfusion),or ischemiareperfusion with the same duration under continuous 3%hydrogen gas inhalation(hydrogen).The distal ileum was *** staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5(LGR5),a specific marker of intestinal stem cell,was conducted to evaluate the injury location and cell types protected by *** expressions of LGR5,olfactomedin 4(OLFM4),hairy and enhancer of split 1,Jagged 2,and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain *** oxidative stress was analyzed with immunostaining for 8-hydroxy-2'-deoxyguanosine(8-OHdG).Systemic oxidative stress was evaluated by plasma *** Ischemia damaged the epithelial layer at the tip of the villi,whereas reperfusion induced extensive apoptosis of the cells at the crypt base,which were identified as intestinal stem cells with double immunofluorescence *** mitigated such apoptosis at the crypt base,and the LGR5 expression of the tissues was higher in the hydrogen group than in the reperfusion ***4 was also relatively higher in the hydrogen group,whereas other measured RNAs were comparable between the groups.8-OHdG concentration was high in the reperfusion group,which was reduced by hydrogen,particularly at the crypt *** 8-OHdG concentrations were relatively higher in both reperfusion and

关键词： hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5

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Compton profile of molecular hydrogen

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Chinese Physics B 2015年第3期24卷 118-121页

作者：赵小利杨科徐龙泉马永朋闫帅倪冬冬康旭刘亚伟朱林繁 Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Shanghai Institute of Applied Physics Chinese Academy of Sciences

The Compton profile of molecular hydrogen has been determined at an incident photon energy of 20 ke V based on the third generation synchrotron radiation, and the statistical accuracy of 0.2% is achieved at p z = 0. Different theoretical methods, i.e., the density functional method, and the Hartree–Fock method, were used to calculate the Compton profiles of hydrogen with different basis sets, and the theoretical calculations are in agreement with the experimental observation in the whole p z region. Compared with the HF calculation, the DFT-B3 LYP ones are in better agreement with the present experiment, which indicates the electron correlation effect is very important to describe the wavefunction in the ground state of hydrogen.

关键词： Compton profile hydrogen molecule electron correlation

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Triple-differential cross section for single ionization of H_2 by electron impact

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Chinese Physics B 2013年第7期22卷 163-166页

作者：王远成刘俊伯马佳刘德军周雅君 Center for Theoretical Atomic and Molecular Physics Academy of Fundamental and Interdisciplinary SciencesHarbin Institute of Technology Department of Communication Engineering Chengdu Technological University Teaching and Research Department Officer's Chinese People's Armed Police Force

The triple-differential cross section （TDCS） for the （e,2e） ionization of a hydrogen molecule is calculated using the molecule distorted-wave Born approximation （MDWBA）. Distorted waves are obtained by solving momentum-space coupled-channel Lippmann-Schwinger equations, including the ground state and the lowest-lying electronic state of b3Σu . TDCSs at the incident energy 100 eV in coplanar asymmetric geometry are reported. The present calculations are compared with the available experimental measurements and the theoretical results.

关键词： (e 2e) collisions hydrogen molecule triple differential cross section

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Efficient Grid Treatment of the Time Dependent Schrodinger Equation for Laser-Driven Molecular Dynamics

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Communications in Computational Physics 2013年第5期13卷 1389-1407页

作者： Fang Li Xiangying Hao Xiaogang Li Laboratory of Optical Information Technology School of ScienceWuhan Institute of TechnologyWuhan 430073China

We present an efficient method to solve the time dependent Schrodinger equation for modeling the dynamics of diatomic molecules irradiated by intense ultrashort laser pulse without Born-Oppenheimer *** introducing a variable prolate spheroidal coordinates and discrete variable representations of the Hamiltonian,we can accurately and efficiently simulate the motion of both electronic and molecular *** accuracy and convergence of this method are tested by simulating the molecular structure,photon ionization and high harmonic generation of H_(2)^(+).

关键词： Time-dependent Schrodinger equation(TDSE) hydrogen molecule non-BornOppenheimer approximation

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Diagnostics of Rovibrational Distribution of H_2 in Low Temperature Plasmas by Fulcher-α band Spectroscopy - on the Reaction Rates and Transition Probabilities

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Plasma Science and Technology 2005年第2期7卷 2773-2776页

作者：肖炳甲 Shinichiro Kado Shin Kajita Daisuge Yamasaki Satoru Tanaka Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031China High temperature plasma research center the university of Tokyo Yayoi 2-11-16Bunkyo-kuTokyoJapan 113-0030 Graduate school of engineering department of quantum engineering and systems sciences the university of Tokyo

A novel fitting procedure is proposed for a better determination of H2 rovibrational distribution from the Fulcher-α band spectroscopy. We have recalculated the transition probabilities and the results show that they deviate from Franck-Condon approximation especially for the non-diagonal transitions. We also calculated the complete sets of vibrationally resolved cross sections for electron impact d3Ⅱu-X3Σg transition based on the semi-classical Gryzinski theory. An example of experimental study confirms that current approach provides a tool for a better diagnostics of H2 rovibrational distribution in electronic ground state.

关键词： Fulcher-a band rovibronic excitation hydrogen molecule

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hydrogen molecular medicine for Alzheimer’s disease’s treatment

Hydrogen molecular medicine for Alzheimer’s disease’s trea...

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第十一届全国化学生物学学术会议

作者： Lei Zhang Qing-Qing Shi Cai-Ping Yue Yi-Tong Lin Xiu-Bo Du Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen University

hydrogen molecule, a special antioxidant, has been seem as a promising potential therapeutic medicine to treat many inflammation-related diseases, including neurodegenerative diseases.[1] Recently, we utilized and designed hydrogen-related compounds to overcome Alzheimer’s disease（AD）. On one hand, we directly utilized traditional hydrogen materials to treat AD mice, i,e. hydrogen-rich water（HRW）. Our results demonstrated that HRW could improve the bioenergetics and regulate the gut microbiota, ultimately exerted anti-inflammatory effects in AD mice. On the other hand, considering hydrogen’s low solubility（1.6 ppm）, we further designed nanoparticles that carry hydrogen or produce hydrogen. In this part, recently, we developed the small-sized Pd hydride（PdH） nanoparticles for high payload of hydrogen and in situ sustained hydrogen release in AD brain. The results showed that PdH nanoparticles effectively improved the mitochondrial function of damaged neurons and promoted the energy metabolism of neurons by inhibiting·OH, and inhibited neuronal apoptosis.[2] All these results support that hydrogen is an effective AD suppressing agent and hydrogen therapy would open a new window for the treatment of neurodegenerative diseases.

关键词： hydrogen molecule Alzheimer’s disease nanoparticles hydrogen therapy

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