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Role of integrin oV in sensitivity to radiotherapy of human npc

The Chinese-German Journal of Clinical Oncology 2009年第2期8卷 86-89页

作者： Haihui Huang Wei Luan Jianjun Li Houjie Liang Department of Oncology Southwest Hospital Third Military Medical University Chongqing 400038 China

Objective： To investigate whether the cell adhesion molecule integrin αV could influence the radiosensitivity of human nasopharyngeal carcinoma cne-2z cells via effecting intercellular effect. Methods： human npc cell line cne-2z was cultivated as three dimensional model using liquid overlay technique. cell counting was employed to detect the radiosensitivity of cne-2z cells by blood cell counter before and after blocking integrin aV function; cell apoptosis was detected by flow cytometry using Annexin V/PI label. Results： Three dimensional culture model of human npc cell line cne-2z cells were successfully established. The integrin αV expression of cne-2z multicellular spheroids elevated as the dosage of radiotherapy increased. Blocking of integrin aV function leaded to higher radiosensitivity and more apoptotic cells of cne-2z multicellular spheroids. Conclusion： cell adhesion molecules integrin aV can influence the radiosensitivity of human nasopharyngeal carcinoma cne-2z cells and the inhibition of cell apoptosis might be its mechanism, proved by three dimensional culture model to mimic solid tumor in vivo.

关键词： human npc cell line cne-2z multicellular spheroids integrin αV radiosensitivity apoptosis

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整合素αⅤ对鼻咽癌cne-2z细胞放疗敏感性的影响(英文)

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Oncology and Translational Medicine 2009年第2期8卷 86-89页

作者： Haihui Huang,Wei Luan,Jianjun Li,Houjie Liang Department of Oncology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China Department of Oncology Southwest Hospital Third Military Medical University Chongqing China

Objective:To investigate whether the cell adhesion molecule integrin αV could influence the radiosensitivity of human nasopharyngeal carcinoma cne-2z cells via effecting intercellular ***:human npc cell line cne-2z was cultivated as three dimensional model using liquid overlay *** counting was employed to detect the radiosensitivity of cne-2z cells by blood cell counter before and after blocking integrin αV function;cell apoptosis was detected by flow cy-tometry using Annexin V/PI ***:Three dimensional culture model of human npc cell line cne-2z cells were suc-cessfully *** integrin αV expression of cne-2z multicellular spheroids elevated as the dosage of radiotherapy *** of integrin αV function leaded to higher radiosensitivity and more apoptotic cells of cne-2z multicellular ***:cell adhesion molecules integrin αV can influence the radiosensitivity of human nasopharyngeal carcinoma cne-2z cells and the inhibition of cell apoptosis might be its mechanism,proved by three dimensional culture model to mimic solid tumor in vivo.

关键词： human npc cell line cne-2z multicellular spheroids integrin αV radiosensitivity apoptosis

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