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In vitro and in vivo investigation on biodegradable Mg-Li-Ca alloys for bone implant application

Science China Materials 2019年第2期62卷 256-272页

作者： Dandan Xia Yang Liu Siyi Wang Rong-Chang Zeng Yunsong Liu Yufeng Zheng Yongsheng Zhou Department of Prosthodontics Peking University School and Hospital of Stomatology Department of Materials Science and Engineering College of Engineering Peking University College of Materials Science and Engineering Shandong University of Science and Technology National Engineering Laboratory for Digital and Material Technology of Stomatology National Clinical Research Center for Oral Diseases Beijing Key Laboratory of Digital Stomatology

Magnesium alloys show promise for application in orthopedic implants, owing to their biodegradability and biocompatibility. In the present study, ternary Mg-(3.5,6.5 wt%) Li-(0.2, 0.5, 1.0 wt%) Ca alloys were developed. Their mechanical strength, corrosion behavior and cytocompatibility were studied. These alloys showed improved mechanical strength than pure Mg and exhibited suitable corrosion resistance. Furthermore, Mg-3.5Li-0.5Ca alloys with the best in vitro performance were implanted intramedullary into the femurs of mice for 2 and 8 weeks. In vivo results revealed a significant increase in cortical bone thickness around the Mg-3.5Li-0.5Ca alloy rods, without causing any adverse *** blotting and immunofluorescence staining of β-catenin illustrated that Mg-3.5Li-0.5Ca alloy extracts induced osteogenic differentiation of human bone marrow-derived mesenchymal stem cells(hBMMSCs) through the canonical Wnt/β-catenin pathway. Our studies demonstrate that Mg-3.5Li-0.5Ca alloys hold much promise as candidates for the facilitation of bone implant application.

关键词： Mg-Li-Ca ahoy cytocompatibility biocompatibility human bone marrow-derived mesenchymal stem cells osteogenic differentiation

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