In vitro and in vivo investigation on biodegradable Mg-Li-Ca alloys for bone implant application

作     者：Dandan Xia Yang Liu Siyi Wang Rong-Chang Zeng Yunsong Liu Yufeng Zheng Yongsheng Zhou 夏丹丹;刘洋;王思仪;曾荣昌;刘云松;郑玉峰;周永胜

作者机构：Department of Prosthodontics Peking University School and Hospital of Stomatology Department of Materials Science and Engineering College of Engineering Peking University College of Materials Science and Engineering Shandong University of Science and Technology National Engineering Laboratory for Digital and Material Technology of Stomatology National Clinical Research Center for Oral Diseases Beijing Key Laboratory of Digital Stomatology 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2019年第62卷第2期

页      面：256-272页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：supported by the National Key Research and Development Program of China (2016YFC1102900 and 2016YFC1102402) the National Natural Science Foundation of China (81771039, 81470769 and 51431002) the Project for Culturing Leading Talents in Scientific and Technological Innovation of Beijing, China (Z171100001117169) the NSFC-RFBR Cooperation Project (51611130054) the NSFC/RGC Joint Research Scheme (51361165101 and 5161101031) 

主　　题：Mg-Li-Ca ahoy cytocompatibility biocompatibility human bone marrow-derived mesenchymal stem cells osteogenic differentiation 

摘      要：Magnesium alloys show promise for application in orthopedic implants, owing to their biodegradability and biocompatibility. In the present study, ternary Mg-(3.5,6.5 wt%) Li-(0.2, 0.5, 1.0 wt%) Ca alloys were developed. Their mechanical strength, corrosion behavior and cytocompatibility were studied. These alloys showed improved mechanical strength than pure Mg and exhibited suitable corrosion resistance. Furthermore, Mg-3.5Li-0.5Ca alloys with the best in vitro performance were implanted intramedullary into the femurs of mice for 2 and 8 weeks. In vivo results revealed a significant increase in cortical bone thickness around the Mg-3.5Li-0.5Ca alloy rods, without causing any adverse *** blotting and immunofluorescence staining of β-catenin illustrated that Mg-3.5Li-0.5Ca alloy extracts induced osteogenic differentiation of human bone marrow-derived mesenchymal stem cells(hBMMSCs) through the canonical Wnt/β-catenin pathway. Our studies demonstrate that Mg-3.5Li-0.5Ca alloys hold much promise as candidates for the facilitation of bone implant application.