检索结果-南通市图书馆

Bioinspired hollow mesoporous silica nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

引用

Journal of Bionic Engineering 2024年第3期21卷 1427-1441页

作者： Jiaxin Zhang He Liu Jincheng Wang Jing Shang Mingwei Xu Xiujie Zhu Chao Xu Haotian Bai Xin Zhao Orthopedic Institute of Jilin Province Orthopedic Medical CenterThe Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130025China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China

3D-printed Porous Titanium Alloy Implants(pTi),owing to their biologically inertness and relatively smooth surface morphology,adversely affect the biological functions of surrounding *** address the challenges,constructing a bioinspired interface that mimics the hierarchical structure of bone tissue can enhance the cellular functions of *** this context,hollow mesoporous silica nanoparticles(HMSNs),renowned for their unique physicochemical properties and superior biocompatibility,offer a promising direction for this *** this research,the initially synthesized HMSNs were used to construct a“hollow-mesoporous-macroporous”hierarchical bioinspired coating on the pTi surface through the Layer-by-Layer ***,diverse morphologies of coatings were established by adjusting the deposition strategy of PDDA/HMSNs on the pTi surface(pTi-HMSN-2,pTi-HMSN-4,pTi-HMSN-6).A range of techniques were employed to investigate the physicochemical properties and regulation of cellular biological functions of the diverse HMSN coating ***,the pTi-HMSN-4 and pTi-HMSN-6 groups exhibited the uniform coatings,leading to a substantial enhancement in surface roughness and ***,the coating constructed strategy of pTi-HMSN-4 possessed commendable *** on the aforementioned findings,both pTi-HMSN-4 and pTi-HMSN-6 facilitated the adhesion,spreading,and pseudopodia extension of BMSCs,which led to a notable upsurge in the expression levels of vinculin protein in *** analysis indicates that the coating,when PDDA/HMSNs are deposited four times,possesses favorable overall *** research will provide a solid theoretical basis for the translation of HMSN bioinspired coatings for orthopedic implants.

关键词： hollow mesoporous silica nanoparticles Bioinspired coating Titanium alloy Hierarchical structure Cellular functions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

hollow mesoporous silica nanoparticles as nanocarriers employed in cancer therapy: A review

引用

Frontiers of Materials Science 2020年第4期14卷 373-386页

作者： Yimin ZHOU Qingni XU Chaohua LI Yuqi CHEN Yueli ZHANG Bo LU School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China

hollow mesoporous silica nanoparticles(HMSNs)have become an attractive drug carrier because of their unique characteristics including stable physicochemical properties,large specific surface area and facile functionalization,especially made into intelligent drug delivery systems(DDSs)for cancer *** are employed to transport traditional anti-tumor drugs,which can solve the problems of drugs with instability,poor solubility and lack of recognition,etc.,while significantly improving the anti-tumor *** an unexpected good result will be obtained by combining functional molecules and metal species with HMSNs for cancer diagnosis and ***,HMSNs-based DDSS have developed relatively mature in recent *** review briefly describes how to successfully prepare an ordinary HMSNs-based DDS,as well as its degradation,different stimuli-responses,targets and combination *** versatile intelligent nanoparticles show great potential in clinical aspects.

关键词： hollow mesoporous silica nanoparticles intelligent drug delivery system stimuli response targeting drug delivery combination therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual responsive block copolymer coated hollow mesoporous silica nanoparticles for glucose-mediated transcutaneous drug delivery

引用

Chinese Journal of Chemical Engineering 2022年第11期51卷 35-42页

作者： Yaping Wang Songyue Cheng Wendi Fan Yikun Jiang Jie Yang Zaizai Tong Guohua Jiang College of Materials Science and Engineering and Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China College of Science Institute of Materials Physics and ChemistryNanjing Forestry UniversityNanjing 210037China

A self-regulated anti-diabetic drug release device mimicking pancreatic cells is highly desirable for the therapy of diabetes. Herein, a glucose-mediated dual-responsive drug delivery system, which combines pH-and H_(2)O_(2)-responsive block copolymer grafted hollow mesoporous silica nanoparticles(HMSNs)with microneedle(MN) array patch, has been developed to achieve self-regulated *** poly[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate]-b-poly[2-(dimethylamino)ethyl methacrylate](PPBEM-b-PDM) polymer serves as gate keeper to prevent drug release from the cavity of HMSNs at normoglycemic level. In contrast, the drug release rate is significantly enhanced upon H_(2)O_(2)and pH stimuli due to the chemical change of H_(2)O_(2)sensitive PPBEM block and acid responsive PDM block. Therefore, incorporation of anti-diabetic drug and glucose oxidase(GOx, which can oxidize glucose to gluconic acid and in-situ produce H_(2)O_(2)) into stimulus polymer coated HMSNs results in a glucose-mediated MN device after depositing the drug-loaded nanoparticles into MN array patch. Both in vitro and in vivo results show this MN device presents a glucose mediated self-regulated drug release characteristic, which possesses a rapid drug release at hyperglycemic level but retarded drug release at normoglycemic level. The result indicates that the fabricated smart drug delivery system is a good candidate for the therapy of diabetes.

关键词： Diabetes Transcutaneous microneedles Stimuli-responsive drug release hollow mesoporous silica nanoparticles Block copolymer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery

引用

Frontiers of Materials Science 2021年第1期15卷 98-112页

作者： Yaping WANG Songyue CHENG Wei HU Xue LIN Cong CAO Shufen ZOU Zaizai TONG Guohua JIANG Xiangdong KONG College of Materials Science and Engineering&Institute of Smart Biomedical Materials&Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices School of ChemistryBiology and Materials ScienceEast China University of TechnologyNanchang 330013China

A glucose-mediated drug delivery system would be highly satisfactory fordiabetes diagnosis since it can intelligently release drug based on blood glucose ***,a glucose-responsive drug delivery system by integrating glucose-responsivepoly(3-acrylamidophenylboronic acid)(PAPBA)functionalized hollow mesoporous silicananoparticles(HMSNs)with transcutaneous microneedles(MNs)has been *** PAPBA serves as gatekeeper to prevent drug release from HMSNs atnormoglycemic *** contrast,faster drug release is detected at a typicalhyperglycemic level,which is due to the change of hydrophilicity of PAPBA at highglucose *** transdermal administration to diabetic rats,an effectivehypoglycemic effect is achieved compared with that of subcutaneous *** indicate that the designed glucose-responsive drug delivery system has apotential application in diabetes treatment.

关键词： hollow mesoporous silica nanoparticles transdermal delivery diabetes glucose-responsive release microneedles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

引用

Progress in Natural Science:Materials International 2019年第6期29卷 612-616页

作者： Thi Ngoc Tram Nguyen Diem-Huong Nguyen-Tran Long Giang Bach Tran Hoang Du Truong Ngoc Thuy Trang Le Dai Hai Nguyen Tra Vinh University Institute of Applied Materials Science Vietnam Academy of Science and Technology Graduate University of Science and Technology Vietnam Academy of Science and Technology Nguyen Tat Thanh University 5. Institute of Research and Development Duy Tan University

A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin(DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the *** with transmission electron microscopy(TEM) and scanning electron microscopy(SEM), X-ray diffraction(XRD), nitrogen adsorption-desorption, thermogravimetric analysis(TGA) and Fourier transformed infrared(FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

关键词： hollow mesoporous silica nanoparticles mPEG PEGylation Surface modification

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

引用

Nano Research 2021年第11期14卷 4264-4273页

作者： Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and MinistryHubei Key Laboratory of Polymer MaterialsHubei UniversityWuhan430062China Glyn O.Philips Hydrocolloid Research Centre at HUT Hubei University of TechnologyWuhan430068China

Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.

关键词： charge-reversal hollow mesoporous silica nanoparticles near-infrared emissive carbon dots dual-stimuli responsive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy

引用

Regenerative Biomaterials 2017年第2期4卷 111-124页

作者： Ling Huang Qingfeng Zhang Liangliang Dai Xinkun Shen Weizhen Chen Kaiyong Cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044P.R.China

This work reports a multifunctional nanocarrier based on hollow mesoporous silica nanoparticles(HMSNs)for targeting tumor ***(DOX)was loaded into HMSNs and blocked with cytochrome C conjugated lactobionic acid(CytC–LA)via redox-cleavable disulfide bonds and pH-disassociation boronate ester bonds as intermediate *** CytC–LA was used both as sealing agent and targeting motif.A series of characterizations demonstrated the successful construction of the drug delivery *** system demonstrated pH and redox dual-responsive drug release behavior in *** DOX loading HMSNs system displayed a good biocompatibility,which could be specifically endocytosed by HepG2 cells and led to high cytotoxicity against tumor cells by inducing cell *** vivo data(tumor volume,tumor weight,terminal deoxynucleotidyl transferase dUTP nick end labeling and hematoxylin and eosin staining)proved that the system could deliver DOX to tumor site with high efficiency and inhibit tumor growth with minimal toxic side effect.

关键词： hollow mesoporous silica nanoparticles dual-response drug delivery targeted tumor therapy in vivo

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence

引用

Chinese Chemical Letters 2018年第12期29卷 1819-1823页

作者： Jing Wu Ying Qu Kun Shi Bingyang Chu Yanpeng Jia Xue Xiao Qianjun He Zhiyong Qian Department of Hematology and Research Laboratory of Hematology State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation Center Department of Gynecology and Obstetrics West China Second University HospitalSichuan University Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of Education National-Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen University

Camptothecin has a strong tumor killing ability for a variety of tumor cells with its special anti-cancer mechanism including the breast cancer. However, because of its infinite hydrophobic property, its clinical application has been greatly limited. Early prevention of loco regional recurrence for the breast cancer is critical for patients who have undergone breast-conserving therapy. In the study,CPT was used for the inhibition of the recurrence after the operation. The hollow mesoporous silica nanoparticles were used as the carrier to improve the hydrophilic property and increase its bioavailability with the high loading capacity. The ability of the cellular uptake and antitumor activity was increased. Hydrogel was the ideal carrier for local therapy, so the CPT@HMSNs were loaded into the PLEL thermo sensitive hydrogel to be injected into the tumor sites after the tumor was resected. The recurrence was reduced in the group of CPT-HMSNs-PLEL and the side effect of CPT was decreased. They exhibit distinguished potential as drug carrier for local delivery.

关键词： Camptothecin hollow mesoporous silica nanoparticles Breast cancer recurrence Thermosensitive hydrogel Local delivery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：