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Possible Role of histone h1 in the Regulation of Furin-dependent Proprotein Processing

Acta Biochimica et Biophysica Sinica 2007年第3期39卷 173-180页

作者： Jinbo hAN~1 Jianxin GU~2 Chengwu ChI~(1,3*) 1 Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China 2 Gene Research Center,Medical Center of Fudan University,Shanghai 200032,China 3 Institute of Protein Research,Tongji University,Shanghai 200092,China Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China.

histone h1 and its C-terminal lysine rich fragments were recently found to be potent inhibitorsof furin,a mammalian proprotein ***,its role in the regulation of furin-dependent proproteinprocessing remains *** we report that histone h1 efficiently blocks furin-dependent pro-yonWillebrand factor（pro-vWF）processing in a dose-dependent *** and immunof-luorescence studies confirmed that histone h1 could interact with furin,and the interaction mainly took placeon the cell *** noted that histone h1 was released from cells undergoing necrosis and apoptosisinduced by *** findings suggested that histone h1 might be involved in extracellular and/or intracellu-lar furin regulation.

关键词： furin histone h1 pro-vWF proprotein processing

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Open and Closed： The Roles of Linker histones in Plants and Animals

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Molecular Plant 2014年第3期7卷 481-491页

作者： Ryan S. Over Scott D. Michaels Departments of Biology/Molecular and Cellular Biochemistry Indiana University 915 E. Third Street Bloomington IN 47405 USA

histones package DNA in all eukaryotes and play key roles in regulating gene expression. Approximately 150 base pairs of DNA wraps around an octamer of core histones to form the nucleosome, the basic unit of chromatin. Linker histones compact chromatin further by binding to and neutralizing the charge of the DNA between nucleosomes. It is well established that chromatin packing is regulated by a complex pattern of posttranslational modifications （PTMs） to core histones, but linker histone function is less well understood. In this review, we describe the current understand- ing of the many roles that linker histones play in cellular processes, including gene regulation, cell division, and devel- opment, while putting the linker histone in the context of other nuclear proteins. Although intriguing roles for plant linker histones are beginning to emerge, much of our current understanding comes from work in animal systems. Many unanswered questions remain and additional work is required to fully elucidate the complex processes mediated by linker histones in plants.

关键词： linker histone histone h1 chromatin gene regulation development differentiation imprinting posttrans-lational modifications DNA methylation high mobility group proteins.

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