Open and Closed： The Roles of Linker Histones in Plants and Animals
Open and Closed： The Roles of Linker Histones in Plants and Animals作者机构：Departments of Biology/Molecular and Cellular Biochemistry Indiana University 915 E. Third Street Bloomington IN 47405 USA
出 版 物：《Molecular Plant》 (分子植物（英文版）)
年 卷 期：2014年第7卷第3期
页 面：481-491页
核心收录：
学科分类：0710[理学-生物学] 080801[工学-电机与电器] 0808[工学-电气工程] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0902[农学-园艺学] 090102[农学-作物遗传育种]
基 金：supported by a grant to SDM from the National Institutes of Health
主 题：linker histone histone H1 chromatin gene regulation development differentiation imprinting posttrans-lational modifications DNA methylation high mobility group proteins.
摘 要：Histones package DNA in all eukaryotes and play key roles in regulating gene expression. Approximately 150 base pairs of DNA wraps around an octamer of core histones to form the nucleosome, the basic unit of chromatin. Linker histones compact chromatin further by binding to and neutralizing the charge of the DNA between nucleosomes. It is well established that chromatin packing is regulated by a complex pattern of posttranslational modifications （PTMs） to core histones, but linker histone function is less well understood. In this review, we describe the current understand- ing of the many roles that linker histones play in cellular processes, including gene regulation, cell division, and devel- opment, while putting the linker histone in the context of other nuclear proteins. Although intriguing roles for plant linker histones are beginning to emerge, much of our current understanding comes from work in animal systems. Many unanswered questions remain and additional work is required to fully elucidate the complex processes mediated by linker histones in plants.
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