检索结果-南通市图书馆

The rice histone methylation regulates hub species of the root microbiota

Journal of Genetics and Genomics 2021年第9期48卷 836-843页

作者： Zhiyao Lv Rui Dai Haoran Xu Yongxin Liu Bo Bai Ying Meng Haiyan Li Xiaofeng Cao Yang Bai Xianwei Song Jingying Zhang College of Life Sciences Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical DevelopmentJilin Agricultural UniversityChangchunJilin 130118China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Shandong Rice Research Institute Shandong Academy of Agricultural SciencesJinan 250100China Institute of Farming and Cultivation Heilongjiang Provincial Academy of Agricultural SciencesHarbin 150086China Center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesBeijing 100101China INASEED Chinese Academy of SciencesBeijing 100101China

Plants have a close relationship with their root microbiota,which comprises a complex microbial *** methylation is an important epigenetic modification influencing multiple plant traits;however,little is known about the role of plant histone methylation in the assembly and network structure of the root *** this study,we established that the rice(Oryza sativa)histone methylation regulates the structure and composition of the root microbiota,especially the hub species in the microbial ***703(defective in histone H3K4 demethylation)and ZH11-sdg714(defective in H3K9 methylation)showed significant different root microbiota compared with the corresponding wild types at the phylum and family levels,with a consistent increase in the abundance of Betaproteobacteria and a decrease in the *** the root microbial network,35 of 44 hub species in the top 10 modules in the tested field were regulated by at least one histone methylation-related *** observations establish that the rice histone methylation plays a pivotal role in regulating the assembly of the root microbiota,providing insights into the links between plant epigenetic regulation and root microbiota.

关键词： histone methylation Root microbiota Hub species Co-occurrence network Rice Epigenetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulation beyond genome sequences: DNA and histone methylation in embryonic stem cells

引用

Frontiers in Biology 2010年第1期5卷 41-47页

作者： Wei YANG Qi ZHOU Xiu-Jie WANG State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate University of the Chinese Academy of Sciences Beijing 100101China

Embryonic stem(ES)cells distinct themselves from other cell type populations by their pluripotent *** unique features of ES cells are controlled by both genetic and epigenetic *** have shown that the methylation status of DNA and histones in ES cells is quite different from that of differentiated cells and somatic stem ***,we summarized recent advances in DNA and histone methylation studies of mammalian ES *** methylation status of several key pluripotent regulatory genes is also discussed.

关键词： Embryonic stem(ES)cells epigenetic DNA methylation histone methylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

引用

World Journal of Hepatology 2024年第5期16卷 703-715页

作者： Li Xu Yu-Hong Fan Xiao-Jing Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000China School of Basic Medical Sciences Wuhan UniversityWuhan 430060China

Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary *** complexity stems from genetic predisposition,environmental influences,and metabolic *** processes govern various cellular functions such as transcription,chromatin structure,and cell *** NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the *** methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to *** early-stage NAFLD is reversible,its progression to severe stages becomes almost ***,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关键词： Non-alcoholic fatty liver disease Mechanism histone methylation Methyltransferases Demethytrasferases Epigenetic modification Adipogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arabidopsis Trithorax histone methyltransferases are redundant in regulating development and DNA methylation

引用

Journal of Integrative Plant Biology 2022年第12期64卷 2438-2454页

作者： Ji-Yun Shang Xue-Wei Cai Yin-Na Su Zhao-Chen Zhang Xin Wang Nan Zhao Xin-Jian He National Institute of Biological Sciences Beijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 100084China

Although the Trithorax histone methyltransferases ATX1-5 are known to regulate development and stress responses by catalyzing histone H3 K4 methylation in Arabidopsis thaliana,it is unknown whether and how these histone methyltransferases affect DNA ***,we found that the redundant ATX1-5 proteins are not only required for plant development and viability but also for the regulation of DNA *** expression and H3 K4 me3 levels of both RNAdirected DNA methylation(RdDM)genes(NRPE1,DCL3,IDN2,and IDP2)and active DNA demethylation genes(ROS1,DML2,and DML3)were downregulated in the atx1/2/4/5 *** with the facts that the active DNA demethylation pathway mediates DNA demethylation mainly at CG and CHG sites,and that the RdDM pathway mediates DNA methylation mainly at CHH sites,whole-genome DNA methylation analyses showed that hyper-CG and CHG DMRs in atx1/2/4/5 significantly overlapped with those in the DNA demethylation pathway mutant ros1 dml2 dml3(rdd),and that hypo-CHH DMRs in atx1/2/4/5 significantly overlapped with those in the RdDM mutant nrpe1,suggesting that the ATX paralogues function redundantly to regulate DNA methylation by promoting H3 K4 me3 levels and expression levels of both RdDM genes and active DNA demethylation *** that the ATX proteins function as catalytic subunits of COMPASS histone methyltransferase complexes,we also demonstrated that the COMPASS complex components function as a whole to regulate DNA *** study reveals a previously uncharacterized mechanism underlying the regulation of DNA methylation.

关键词： development DNA demethylation DNA methylation histone methylation NRPE1 ROS1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins

引用

Science China(Life Sciences) 2017年第2期60卷 138-151页

作者： Meng Wu Wei Wei Jiwei Chen Rong Cong Tieliu Shi Jiwen Li Jiemin Wong James X.Du Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Collaborative Innovation Center for Cancer Medicine Sun Yat-Sen University Cancer CenterGuangzhou 510060China University de Lyon Ecole Normale Supdrieure de LyonCNRS USR 3010Laboratoire Joliot-CurieLyon 69364France

histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin （NPM 1）, pp32, SET/TAF 113, nucleolin （NCL） and upstream binding factor （UBF） are novel H3K4me2-binding proteins. These proteins exhibit a unique pattern of interaction with methylated H3K4, as their binding is stimulated by H3K4me2 and inhibited by H3K4mel and H3K4me3. These proteins contain one or more acidic domains consisting mainly of aspartic and/or glutamic residues that are necessary for preferential binding of H3K4me2. Furthermore, we demonstrate that the acidic domain with sufficient length alone is capable of binding H3K4me2 in vitro and in vivo. NPM1, NCL and UBF require their acidic domains for association with and transcriptional activation ofrDNA genes. Interestingly, by defining acidic domain as a sequence with at least 20 acidic residues in 50 continuous amino acids, we identified 655 acidic domain-containing protein coding genes in the human genome and Gene Ontology （GO） analysis showed that many of the acidic domain proteins have chromatin-related functions. Our data suggest that acidic domain is a novel histone binding motif that can differentially read the status of H3K4 methylation and is broadly present in chromatin-associated proteins.

关键词： histone methylation H3K4mel H3K4me2 H3K4me3 acidic domain histone code transcription chromatin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines

引用

World Journal of Gastroenterology 2007年第46期13卷 6166-6171页

作者： Chun-Feng Meng Xin-Jiang Zhu Guo Peng Dong-Qiu Dai Department of Surgical Oncology The First Affiliated HospitalChina Medical University Shenyang 110001 Liaoning ProvinceChina

AIM： To identify the relationship between DNA hyper- methylation and histone modification at a hyperme- thylated, silenced tumor suppressor gene promoter in human gastric cancer cell lines and to elucidate whether alteration of DNA methylation could affect histone modification. METHODS： We used chromatin immunoprecipitation （CHIP） assay to assess the status of histone acetylation and methylation in promoter regions of the p16 and rnutL homolog 1 （MLH1） genes in 2 gastric cancer cell lines, SGC-7901 and MGC-803. We used methylation- specific PCR （MSP） to evaluate the effect of 5-Aza-2＇- deoxycytidine （5-Aza-dC）, trichostatin A （TSA） or their combination treatment on DNA methylation status. We used RT-PCR to determine whether alterations of histone modification status after 5-Aza-dC and TSA treatment are reflected in gene expression. RESULTS： For thep16 and MLH1 genes in two cell lines, silenced loci associated with DNA hypermethylation were characterized by histone H3-K9 hypoacetylation and hypermethylation and histone H3-K4 hypomethylation. Treatment with TSA resulted in moderately increased histone H3-K9 acetylation at the silenced loci with no effect on histone H3-K9 methylation and minimal effects on gene expression. In contrast, treatment with 5-Aza- dC rapidly reduced histone H3-K9 methylation at the silenced loci and resulted in reactivation of the two genes. Combined treatment with 5-Aza-dC and TSA was synergistic in reactivating gene expression at the loci showing DNA hypermethylation. Similarly, histone H3-K4 methylation was not affected alter TSA treatment, andincreased moderately at the silenced loci after 5-Aza-dC treatment. CONCLUSION： Hypermethylation of DNA in promoter CpG islands is related to transcriptional silencing of tumor suppressor genes. histone H3-K9 methylation in different regions of the promoters studied correlates with DNA methylation status of each gene in gastric cancer cells. However, histone H3-K9 acetylation and H3-K4 methylation in

关键词： Gastric cancer DNA hypermethylation histone methylation histone acetylation p16 mutLhomolog 1 5-Aza-2'-deoxycytidine, Trichostatin A

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications

引用

Protein & Cell 2023年第3期14卷 165-179页

作者： Yanjing Li Kexue Gei Tingting Li Run Cai Yong Chen State Key Laboratory of Molecular Biology National Center for Protein Science ShanghaiShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academyof Sciences320 Yue Yang RoadShanghai 200031China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai Collaborative Innovation Center for Biomanufacturing(SCICB)Meilong Road 130Shanghai 200237China

histone lysine methyltransferases(HKMTs)deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene *** structures and functions of HKMTs have been extensively investigated in recent decades,significantly advancing our understanding of the dynamic regulation of histone ***,we review the recent progress in structural studies of representative HKMTs in complex with nucleosomes(H3K4,H3K27,H3K36,H3K79,and H4K20 methyltransferases),with emphasis on the molecular mechanisms of nucleosome recognition and trans-histone crosstalk by these *** structural studies inform HKMTs'roles in tumorigenesis and provide the foundations for developing new therapeutic approachestargetingHKMTs incancers.

关键词： nucleosome cryo-EM structures histone methyltransferases epigenetics histone methylation tumorigenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering the coordinated regulation of gene silencing and pathogenicity by histone methylations in a plant fungal pathogen ***

Deciphering the coordinated regulation of gene silencing and...

引用

中国菌物学会2024年学术年会

作者：王海婷杨杰单淳敏植物基因组学国家重点实验室中国科学院微生物研究所中国科学院大学

In eukaryotes,previous studies often considered the control of histone H3K9me3 and H3K27me3,two major methylation markers critical for heterochromatin structures and epigenetic regulation of genetic information,as independent pathways,recruited and catalyzed by different complexes with site ***,recent findings have demonstrated that these modifications can co-occur at the same gene locus,suggesting that despite their functional differentiation,H3K9me3 and H3K27me3 exhibit complementarity and synergistic *** the study of the coordinated regulation mechanism of H3K9me3 and H3K27me3 is still in the early stages,and many studies have implicated histone methylation in fungal pathogenesis,we utilized Verticillium dahliae,a fungus possessing both modifications and capable of causing severe plant vascular disease,as a model organism to investigate the coordinated regulation of gene silencing and pathogenicity by histone H3K9 and H3K27 *** mutated the histone H3K9me3 and H3K27me3 methyltransferases Vd KMT1 and Vd EZH2in *** and observed significant upregulation of numerous genes,indicating the crucial roles of both histone H3K9me3 and H3K27me3 in gene *** in situ labeling of Vd KMT1and Vd EZH2,combined with native complex extraction and mass spectrometry analysis,we identified the essential components of the complexes and verified their *** further explore the coordinated regulation mechanism of H3K9me3 and H3K27me3,we employed CUT&Tag-seq to detect the H3K9me3 and H3K27me3 levels in the methyltransferase mutants VdΔKMT1 and VdΔEZH2,respectively,and conducted joint analysis with transcriptome *** results revealed that the regulation of gene expression by H3K9me3 levels is achieved through indirect regulation of H3K27me3 ***,in the absence of Vd EZH2,the composition of a histone chaperone RbAp48 might increase in the Vd KMT1 complex to recruit Vd KMT1 to exert the functions of both H3

关键词： histone methylation Methyltransferase Gene silencing Pathogenicity Verticillium dahliae

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

引用

Acta Pharmaceutica Sinica B 2023年第6期13卷 2601-2612页

作者： Xiaomin Wang Jun Xu Yiming Sun Siyuwei Cao Hanlin Zeng Nan Jin Matthew Shou Shuai Tang Yi Chen Min Huang Cancer Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Division of Diabetes Endocrinology and MetabolismDepartment of Molecular Physiology and BiophysicsVanderbilt University Medical CenterNashvilleTN 37232USA

Epigenetic therapies that cause genome-wide epigenetic alterations,could trigger local interplay between different histone marks,leading to a switch of transcriptional outcome and therapeutic responses of epigenetic ***,in human cancers with diverse oncogenic activation,how oncogenic pathways cooperate with epigenetic modifiers to regulate the histone mark interplay is poorly *** herein discover that the hedgehog(Hh)pathway reprograms the histone methylation landscape in breast cancer,especially in triple-negative breast cancer(TNBC).This facilitates the histone acetylation caused by histone deacetylase(HDAC)inhibitors and gives rise to new therapeutic vulnerability of combination ***,overexpression of zinc finger protein of the cerebellum 1(ZIC1)in breast cancer promotes Hh activation,facilitating the switch of H3K27 methylation(H3K27me)to acetylation(H3K27ac).The mutually exclusive relationship of H3K27me and H3K27ac allows their functional interplay at oncogenic gene locus and switches therapeutic *** multiple in vivo breast cancer models including patient-derived TNBC xenograft,we show that Hh signaling-orchestrated H3K27me and H3K27ac interplay tailors combination epigenetic drugs in treating breast ***,this study reveals the new role of Hh signaling-regulated histone modifications interplay in responding to HDAC inhibitors and suggests new epigenetically-targeted therapeutic solutions for treating TNBC.

关键词： HDAC inhibitors Drug resistance histone methylation histone acetylation Epigenetic interplay Hedgehog pathway ZIC1 LIFR Combination therapy Breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetic regulation of mesenchymal stem cell aging through histone modifications

引用

Genes & Diseases 2023年第6期10卷 2443-2456页

作者： Yanping Sun Haoyu Zhang Tao Qiu Li Liao Xiaoxia Su State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatrics&Engineering Research Center of Oral Translational Medicine Ministry of EducationWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

Stem cell senescence and exhaustion,a hallmark of aging,lead to declines in tissue repair and regeneration in aged *** evidence has revealed that epigenetic regulation plays critical roles in the self-renew,lineage-commitment,survival,and function of stem ***,epigenetic alterations are considered important drivers of stem cell dysfunction during *** this review,we focused on current knowledge of the histone modifications in the aging of mesenchymal stem cells(MSCs).The aberrant epigenetic modifications on histones,including methylation and acetylation,have been found in aging *** disturbing the expression of specific genes,these epigenetic modifications affect the self-renew,survival,and differentiation of MSCs.A set of epigenetic enzymes that write or erase these modifications are critical in regulating the aging of ***,we discussed the rejuvenation strategies based on epigenetics to prevent stem cell aging and/or rejuvenate senescent MSCs.

关键词： Aging Epigenetic histone acetylation histone methylation Mesenchymal stem cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：