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Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam Sharma Subh Naman Ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

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The use of Chinese herbal drugs in Islamic medicine

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Journal of Integrative Medicine 2015年第6期13卷 363-367页

作者： Mojtaba Heyadri Mohammad Hashem Hashempur Mohammad Hosein Ayati Detlev Quintern Majid Nimrouzi Seyed Hamdollah Mosavat Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences Department of Traditional Persian Medicine School of MedicineShiraz University of Medical Sciences Department of Traditional Medicine Fasa University of Medical Sciences Noncommunicable Diseases Research Center Fasa University of Medical Sciences Department of Traditional Medicine School of Traditional MedicineTehran University of Medical Sciences Department of History of Science Fatih Sultan Mehmet Vakif University Essence of Parsiyan Wisdom Institute Traditional Medicine and Medicinal Plant IncubatorShiraz University of Medical Sciences

This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam （8th to 13th century CE）, the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari （870 CE）, Rhazes （925 CE）, Haly Abbas （982 CE）, Avicenna （1037 CE） and Jurjani （1137 CE）. The term al-sin （the Arabic word for China） is used 46 times in Avicenna＇s Canon of Medicine in reference to herbal drugs imported from China. Cinnamon （dar sini; ＂Chinese herb＂）, wild ginger （asaron）, rhubarb （rivand-e sini）, nutmeg （basbasa）, incense tree wood （ood）, cubeb （kababe） and sandalwood （sandal） were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era.

关键词： history of medicine, Chinese medicine Islamic medicine herbal drugs Golden Age of Islam

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Tongluo Jiedu as an adjuvant therapy for oral cancer

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World Journal of Clinical Cases 2025年第5期13卷 52-57页

作者： Sarah Monserrat LomelíMartínez Melissa Martínez Nieto Ana Esther Mercado González Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Department of Well-being and Sustainable Development Centro Universitario del NorteUniversidad de GuadalajaraColotlan 46200Mexico Independent Researcher Guadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Universidad de GuadalajaraGuadalajara 44280Mexico

Oral cancer is one of the malignant neoplasms that present major global health *** is the sixth most prevalent type of cancer in the world,with a high incidence and mortality *** letter is a review of the study by Yin et al which was published in the World Journal of Clinical Cases(2024).The study evaluated the effect of Tongluo Jiedu as an adjuvant treatment for oral *** the years,there has been a continuous search for effective and less invasive treatments for oral *** article emphasizes and discusses various therapeutic options currently available,and it highlights that early intervention and multidisciplinary management are crucial for improving *** Chinese medicine,particularly Tongluo Jiedu,presents potential complementary approach to co-nventional oral cancer *** research on Tongluo Jiedu should be focused on validation of its efficacy and safety through large,well-designed clinical trials,as well as better understanding of the molecular mechanisms in-volved,and optimization of therapeutic ***,continuous education of health professionals is key to the effective and safe integration of this traditional medicine into clinical *** research is essential for optimization of therapeutic strategies and for addressing the challenges presented by this neoplasm.

关键词： Oral cancer Tongluo Jiedu Traditional Chinese medicine Chinese herbal medicine herbal drugs Dentistry

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In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae

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Journal of Integrative Medicine 2018年第4期16卷 255-262页

作者： Carola Analla Torres Cristina Marisel Perez Zamora Maria Beatriz Nunez Ana Maria Gonzalez Laboratory of Microbiology and Pharmaceutical Technology Department of Basic and Applied SciencesNational University of Chaco AustralPresidencia Roque Saenz Pena 3700ChacoArgentina National Council for Scientific and Technical Research(CONICET) Godoy Cruz 2290Buenos Aires C1425FQBArgentina Institute of Botany of the Northeast(IBONE-CONICET) Sargento Juan Bautista Cabral 2131CorrientesArgentina

Objectives： This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalyrnrna rnarginatum （Cham.） DC., Amphilophium vauthieri DC., Cuspidaria convoluta （VEIL） A. H. Gentry, Dolichandra dentata （K. Schum.） L. G. Lohmann, Fridericia caudigera （S. Moore） L. G. Lohmann, Fridericia chica （Bonpl.） L. G. Lohmann and Tanaecium selloi （Spreng.） L. G. Lohmann. Methods： The antioxidant activity was evaluated using three methods, 2,2＇-azino-bis（3-ethylbenzothiazo line-6-sulfonic acid）（ABTS）, 2,2-diphenyl-l-picrylhydrazyl （DPPH）, and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method. Minimal inhibitory concentration （MIC） and minimal bactericidal]fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography-tandem mass spectrometry. Results： C convoluta, F. caudigera, and F. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS~ radicals and reducing Fe3＋ ion. These extracts showed a notable inhibition of lipnxygenase. F. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species. The extracts of F. caudigera and C. convoluta were active even against methicillin-resistant S. aureus. C convoluta had higher total phenol content, better antioxidant activity and superior anti- inflammatory and antimicrobial activity. The main phenolic compounds found in this extract

关键词： Cuspidaria Fridericia Antioxidants Lipoxygenase Antimicrobials herbal drugs Free radical scavengers

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Chemometrics:A new scenario in herbal drug standardization

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Journal of Pharmaceutical Analysis 2014年第4期4卷 223-233页

作者： Ankit Bansal Vikas Chhabra Ravindra K.Rawal Simant Sharma Indo-Soviet Friendship(ISF) College of Pharmacy MogaPunjab 142001India

Chromatography and spectroscopy techniques are the most commonly used methods in standardization of herbal medicines but the herbal system is not easy to analyze because of their complexity of chemical composition. Many cutting-edge analytical technologies have been introduced to evaluate the quality of medicinal plants and significant amount of measurement data has been produced. Chemometric techniques provide a good opportunity for mining more useful chemical information from the original data. Then, the application of chemometrics in the field of medicinal plants is spontaneous and necessary. Comprehensive methods and hyphenated techniques associated with chemometrics used for extracting useful information and supplying various methods of data processing are now more and more widely used in medicinal plants, among which chemometrics resolution methods and principal component analysis （PCA） are most commonly used techniques. This review focuses on the recent various important analytical techniques, important chemometrics tools and interpretation of results by PCA, and applications of chemometrics in quality evaluation of medicinal plants in the authenticity, efficacy and consistency,

关键词： ChemometricsHELP herbal drugs PCA OPA

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Formulation optimization and characterization of transdermal film of curcumin by response surface methodology

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Chinese herbal Medicines 2021年第2期13卷 274-285页

作者： Priyanka Kriplani Kumar Guarve Uttam Singh Baghel Guru Gobind Singh College of Pharmacy Yamuna Nagar135001India I.K.Gujral Punjab Technical University Jalandhar 144603India Department of Pharmacy University of KotaKota 324005India

Objective:India is referred as goldmine of herbal drugs but still lack of optimization of herbal drugs,which has kept us on the back *** rationale of the study is to prepare optimized transdermal drug delivery system of curcumin employing response surface methodology to study the collective effect of independent variables like concentration of ethyl cellulose,hydroxyl propyl methyl cellulose and dibutyl phthalate which significantly influenced characteristics like percentage elongation and in vitro drug ***:Twenty formulations containing varying concentrations of polymers and permeation enhancer were prepared using solvent casting ***:The study revealed that the effect of dibutyl phthalate(DBP) concentration was the highest on percentage elongation(P herbal formulations is carried out,they can become the first choice for patients as compare to synthetic drugs.

关键词： Curcumin herbal drugs osteoarthritis formulation optimization transdermal film

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Management of functional dyspepsia: Unsolved problems and new perspectives

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World Journal of Gastroenterology 2005年第42期11卷 6577-6581页

作者： Ahmed Madisch Stephan Miehlke Joachim Labenz Medical Department Ⅰ Technical University Hospital Dresden Germany Medical Department Ev. Jung-Stilling-Hospital Academic Teaching Hospital of the University of Bonn Siegen Germany

The common characteristic criteria of all functional gastrointestinal(GI)disorders are the persistence and recurrence of variable gastrointestinal symptoms that cannot be explained by any structural or biochemical abnormalities. Functional dyspepsia (FD) represents one of the important GI disorders in Western countries because of its remarkably high prevalence in general population and its impact on quality of life. Due to its dependence on both subjective determinants and diverse country-specific circumstances, the definition and management strategies of FD are still variably *** trials with several drug classes (e.g., proton pump inhibitors, H2-blockers, prokinetic drugs) have been performed frequently without validated diseasespecific test instruments for the outcome ***, the interpretation of such trials remains difficult and controversial with respect to comparability and evaluation of drug efficacy, and definite conclusions can be drawn neither for diagnostic management nor for efficacious drug therapy so far. In view of these unsolved problems, guidelines both on the clinical management of FD and on the performance of clinical trials are needed. In recent years, increasing research work has been done in this area. Clinical trials conducted in adequately diagnosed patients that provided validated outcome measurements may result in better insights leading to more effective treatment *** perspectives have been recently performed by methodologically well-designed treatment studies with herbal drug preparations. herbal drugs, given their proven efficacy in clinical trials, offer a safe therapeutic alternative in the treatment of FD which is often favored by both patients and physicians. A fixed combination of peppermint oil and caraway oil in patients suffering from FD could be proven effective by well-designed clinical trials.

关键词： Dyspepsia Functional dyspepsia Definition Diagnosis Management Drug efficacy Clinical trials Outcome measurements herbal drugs

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Challenges and opportunities in the treatment of ulcerative colitis

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World Journal of Pharmacology 2015年第2期4卷 219-226页

作者： Sunil Ashokrao Nirmal Sunil Shivaji Gangurde Pratiksha Shankar Dumbre Subodh Chandra Pal Subhash Chandra Mandal Department of Pharmacognosy Pravara Rural College of Pharmacy Biotechnology Centre Post Graduate InstituteDr. PDKVMaharashtra 413736India Sarswati Vidyabhavan College of Pharmacy Department of Pharmacognosy NDMVP’s College of Pharmacy Pharmacognosy and Phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur University

Ulcerative colitis(UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Many synthetic drugs are available for the treatment of UC like 5-aminosalicylic acid, oral or systemic corticosteroids, immunomodulator, etc. but these drugs are associated with many serious side effects after long term use or have certain disadvantage or not suitable for the use in some patients. In short synthetic drugs have many disadvantages and for this reason effective and safe alternative drug treatment for the UC is the challenge. herbal drugs are found to be very promising results of the treatment of UC and enzymatic level. Researchers explored many herbal drugs for the treatment and even many more may found effective in the treatment of UC. At this point we feel herbal medicine is the better alternative for the treatment of UC.

关键词： Ulcerative colitis herbal drugs Synthetic drugs

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Phytochemistry and pharmacology of ornamental gingers,Hedychium coronarium and Alpinia purpurata:a review

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Journal of Integrative Medicine 2015年第6期13卷 368-379页

作者： Eric Wei Chiang Chan Siu Kuin Wong Faculty of Applied Sciences UCSI University School of Science Monash University

In this review, the phytochemistry and pharmacology of two ornamental gingers, Hedychium coronarium （butterfly ginger） and Alpinia purpurata （red ginger）, are updated, and their botany and uses are described. Flowers of H. coronarium are large, showy, white, yellow or white with a yellow centre and highly fragrant. Inflorescences of A. purpurata are erect spikes with attractive red or pink bracts. Phytochemical investigations on the rhizomes of H. coronarium generated research interest globally. This resulted in the isolation of 53 labdane-type diterpenes, with little work done on the leaves and flowers. Pharmacological properties of H. coronarium included antioxidant, antibacterial, antifungal, cytotoxic, chemopreventive, anti-allergic, larvicidal, anthelminthic, analgesic, anti-inflammatory, anti-urolithiatic, anti-angiogenic, neuro- pharmacological, fibrinogenolytic, coagulant and hepatoprotective activities. On the contrary, little is known on the phytochemistry of A. purpurata with pharmacological properties of antioxidant, antibacterial, larvicidal, cytotoxic and vasodilator activities reported in the leaves and rhizomes. There is much disparity in terms of research effort within and between these two ornamental gingers.

关键词： herbal drugs plant extracts molecular mechanisms of pharmacological action pharmacology Zingiberaceae ginger review

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Effect of Chinese herbal medicine on lung disease:an updated review

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Cancer Advances 2022年第27期5卷 1-8页

作者： Virender Kumar Davinder Kumar Naveen Khatri Ashwani Kumar Joginder Khurana College of Pharmacy Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohatk 124001HaryanaIndia Department of Pharmaceutical Sciences VishwavidyalayaJagjeetpurHaridwarUttarakhand 249404India Tirupati Wellness Ltd. FH57+7Q7Puruwala SantokhgarhHimachal Pradesh 173021India

A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the *** we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and therapies available for those disorders have not progressed *** to existing therapies are made from traditional natural derivatives and herbal *** compounds such as these are capable of acting as the basis for developing new drugs and related *** possess bioactive compounds that have distinct advantages over allopathic medicines because chemotherapy roots severe adverse effects rather than providing limited *** a result of better effects and fewer adverse effects,herbal bioactive is a promising approach for treating respiratory disorders,resulting in a better quality of life and longer life expectancy for ***,pulmonary fibrosis,lung cancer,and chronic obstructive pulmonary disease are among the pulmonary disorders addressed in the present article and approaches based on clinical trials.

关键词： herbal drugs delivery lung cancer asthma respiratory disorders

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