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Phytoconstituents Profiling of Indigenous herbal drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome Coronavirus 2

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 121-136页

作者： T.H.Mohamed Ahadu Shareef MMohamed Divan Masood Irfan Navabshan MSaiyad Musthafa Department of Chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of Computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,COVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1H-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid Chromatography(HPLC),Gas Chromatography-Mass Spectrometry(GC-MS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using HPLC and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-Co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-Co V-2 NSP5(PDB ID:7nxh)and SARS-Co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

HPTLC-MS: an advance approach in herbal drugs using fingerprint spectra and mass spectroscopy

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Traditional Medicine Research 2023年第2期8卷 21-35页

作者： Babita Sharma Atiqul Islam Alok Sharma Department of Pharmaceutical Analysis ISF College of PharmacyMoga 142001India Department of Pharmacognosy ISF College of PharmacyMoga 142001India

High-performance thin-layer chromatography-mass spectrometry(HPTLC-MS)is one of the most modern hyphenated analytical methods available ***-MS has recently been used to perform extensive analytical work using advanced features and still more analyses are in progress using these advanced *** medicines contain a wide range of bioactives that require proper identification for the activity and quality ***,herbal medicine identification and quality control have become increasingly popular using high-performance liquid chromatography mass *** aim of this paper is to provide a brief overview of recent method developments in analysis,15 most significant herbal drug applications with their chromatographic conditions,pharmacological actions,and solvents used in the present *** extensive literature search was performed incorporating several databases,notably,Web of Knowledge,PubMed and Google Scholar,and other relevant published *** previous research,HPTLC and its hyphenation with MS allowed for quantification of analytes in complex matrixes at nanogram and picogram *** a wide variety of analytes using these techniques has been extremely accurate,selective,and *** this review,the HPTLC-MS technique is discussed in relation to the quality control of herbal ***,15 herbal drugs were identified based on their RF values and m/z ratio by mass spectrometry by HPTLC-MS for the first *** this compilation,researchers can gain insights into HPTLC-MS techniques for resolving quality control issues with herbal drugs using their fingerprint ***,the application of HPTLC-MS methods could to be sufficiently precise and reproducible for established conditions and after validation may be used for routine quality control of herbal drugs/formulations in herbal industries.

关键词： chromatography herbal drug HPTLC-MS mass spectrometry quality control

Screening Test for Antibiotics in Medicinal Plants(STAMP):Using Powdered Plant Materials Instead of Extracts

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American Journal of Plant Sciences 2013年第12期4卷 2340-2350页

作者： Marielle Cascaes Inácio Fabio Carmona Tiago Antunes Paz Maysa Furlan Fernando Arcanjo da Silva Bianca Waléria Bertoni Suzelei de Castro Franca Ana Maria Soares Pereira Departamento de Producao Vegetal Faculdade de Ciências AgronomicasUniversidade Estadual Paulista“Júlio de Mesquita Filho”BotucatuBrasil Departamento de Puericultura e Pediatria Faculdade de Medicina de Ribeirao PretoUniversidade de Sao PauloRibeirao PretoBrasil Departamento de Química Orgânica Instituto de QuímicaUniversidade Estadual Paulista“Júlio de Mesquita Filho”AraraquaraBrasil Unidade de Biotecnologia Universidade de Ribeirao PretoRibeirão PretoBrasil

Plants are a rich source of antibiotics, but screening all the existing plant species for biological activity using current methods can be time and resource consuming. The present study is to investigate whether powdered plant materials would perform as well as plant extracts in the screening of plants with antimicrobial activity. In the new method proposed (STAMP), we compared in vitro antimicrobial activity of powdered plant materials from 12 species against bacteria and fungi. We confirmed these results with their corresponding aqueous (wet) and hydro-alcoholic extracts and one species testing the antimicrobial activity of two isolated compounds. Compared with hydro-alcoholic extracts, screening using the powdered plant materials correctly identified the majority of the species with antimicrobial activity against Candida albicans (sensitivity 91%, specificity 86%), C. parapsilosis (sensitivity 100%, specificity 67%), and Staphylococcus aureus (sensitivity 64%, specificity 86%). For bacteria, the method performed better in a pH of 9.0. The antimicrobial activity of two compounds isolated from one species (maytenin and netzahualcoyone) confirmed the results. In conclusion, the use of powdered plant materials for screening plants with antimicrobial properties is a cheap, widely available, technically easy, time sparing, reproducible, and sensitive method and can significantly shorten the time and money spent during drug development.

关键词： herbal drug Botanical drug Phytotherapics Natural Products

Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna Patel Vivek Hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical herbal drug Traditional Chinese medicine

Comparative Analyses of the Efficacy of Dry and Fresh Mangifera indicaEthanolic Extracts on E. coliand S. aureus

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Journal of Biosciences and Medicines 2020年第9期8卷 56-68页

作者： Smart Enoch Amala Tombari Pius Monsi Monday Wisdom Nyimanu Omah Department of Medical Laboratory Science Rivers State University Port Harcourt Nigeria

Background: The need to identify and characterize new antimicrobial agents is important due to the increasing development of resistance by microorganisms to the existing antimicrobial agents. Aim: This study examined the efficacies of Mangifera indica on Escherichia coli and Staphylococcus aureus. Method: Three parts (leaf [L], root [R], and bark [B]) of the plant were analyzed. The extraction of the samples was performed by aseptically grinding the samples, dissolving in absolute ethanol, and filtering through whatman filter paper. The efficacy of the extracts bothsingle and combined was determined using agar well diffusion assay with gentamycin [10 μl] (E. coli) and vancomycin [30 μl] (S. aureus) as control antibiotics. Results: The higher concentration (C2 = 3.0 g/ml) showed more antibacterial effectiveness than the lower concentration (C1 = 1.5 g/ml) against both bacterial isolates with significant differences (P E. coli dry leaf extract;fresh bark extract), double extracts (S. aureus: dry and fresh leaf extracts) and triple extract (E. coli and S. aureus dry extracts). For the single extracts the bacteria has the following significant results: E. coli L (dry 6.3 ± 2.5 mm, fresh 14.7 ± 0.6 mm, P = 0.0050), R (dry 11.3 ± 1.5 mm, fresh 7.3 ± 1.5 mm, P = 0.0327);for S. aureus L (dry 7.0 ± 1.7 mm, fresh 11.0 ± 1.0 mm, P = 0.0257), R (dry 7.0 ± 2.0 mm, fresh 11.7 ± 1.5 mm, P = 0.0325), and B (dry 5.0 ± 1.0 mm, fresh 16.0 ± 1.0 mm, P = 0.0002). For the double extracts the bacteria has the following significant results: E. coli L + R (dry 15.7 ± 2.3 mm, fresh 1.7 ± 1.5 mm, P = 0.0070), R + B (dry 18.7 ± 1.5 mm, fresh 9.7 ± 1.5 mm, P =

关键词： Mangifera indica Susceptibility Testing herbal drug Single and Combination Therapy